Belgian cardiac cell therapies firm Cardio3 BioSciences established a U.S. subsidiary in Rochester, MN, to support its clinical and development activities and to bolster existing links with the Mayo Clinic and other U.S. collaborators, according to GEN News. Cardio3’s lead product, C3BS-CQR-1 is a stem cell-based cardiac lineage in clinical development for the treatment of heart failure. Phase III studies are projected to start in 2012.
Having a base in the U.S. will allow the firm to substantiate early evidence of the feasibility, safety, and efficacy of C-Cure in a larger-scale setting, including phase III studies, and strengthen its ongoing research and commercialization relationship with the Mayo Clinic, which developed the cardiopoiesis technology on which Cardio3’s platform has been built.
Founded in 2007, Cardio3 is focused on the development of regenerative and protective therapies for the treatment of cardiac disease. Lead product candidate C-Cure is based on a patient’s own bone marrow stem cells, which are treated with a cardiopoietic cocktail before being re-injected into the heart to generate heart muscle cells. The firm says the treatment acts both directly, through the proliferation, engraftment, and terminal differentiation of the injected cells, as well as indirectly, through the beneficial effect on the patient’s existing cardiac stem cells of factors secreted by the transplanted cells.