EMD Serono, a subsidiary of Merck, has signed a research agreement with Pfizer and the Broad Institute in Cambridge, Mass. The collaboration is focused on the genomic profiling of Systemic Lupus Erythematosus (SLE) and Lupus Nephritis (LN) patients. The research project will be jointly funded by EMD Serono and Pfizer.
SLE is a systemic autoimmune disease, and can cause LN, an inflammation of the kidney. In SLE patients, in addition to the kidney, other tissues and organs can be affected, including the skin, the nervous system or joints.
The Broad Institute will investigate clinical samples obtained from SLE and LN patients, applying biochemical and next-generation sequencing technologies. The Institute also will analyze immune cell subpopulations. The goal is to identify biomarkers to better define target patient populations for future therapies. In addition, through computational modeling approaches, the project aims to identify key molecular drivers of SLE and LN kidney flares, and thereby to discover potential novel drug targets as the basis for innovative therapies.
EMD Serono and Pfizer, as sponsoring members, will receive real-time access to all data and analysis. In addition, both companies will have the ability to send a research scientist to the Broad Institute to foster exchange of technology expertise in computational and experimental genomic profiling.
Nir Hacohen, associate professor at Massachusetts General Hospital and Harvard Medical School, and senior associate member at the Broad Institute, said, "Technical advances now make it possible for us to sequence RNA in very small numbers of cells, enabling us to be more comprehensive in our analysis of cell types and states in Lupus patients. We will collect millions of unbiased measurements from lupus patients over many time points along with key clinical variables. We will use this dataset to infer active biological pathways in these patients and develop novel dynamic models of Lupus pathogenesis."
"The research group of Prof. Nir Hacohen from the Broad Institute is a pioneer in systems immunology and has developed a unique strategy to dissect Lupus and Lupus Nephritis," said Harsukh Parmar, head of the Translational Innovation Platform Immunology and Neurodegenerative Diseases at EMD Serono. "Combined with the Broad Institute's technical know-how, we see this collaboration aiming for a significant contribution to potential future innovative treatments of Lupus and Lupus Nephritis. This is in line with our concept to integrate genomic profiling and system biology approaches throughout our preclinical and clinical programs."