Cancer Research U.K. has launched Grand Challenges—big, global cancer grants—which aim to overcome the greatest barriers standing in the way of beating cancer.

The £100 million ($153.6 million) investment intends to revolutionize how people diagnose, prevent and treat cancer by uniting teams of the best scientists around the world to come up with answers to questions about how to save more lives from cancer.

A panel of scientists worked with cancer researchers and patients worldwide to set seven challenges, which covered unanswered questions in cancer research. Cancer Research U.K. now will invite international scientists across all disciplines from academia, technology and business to come up with approaches to tackle the problems.

The first winning proposal will be announced in the autumn of 2016, with the successful team awarded up to £20 million ($30.7 million) to fund five or more years of research. 

During the next five years Cancer Research U.K. plans to make at least five Grand Challenge awards to stimulate fresh thinking and investment in multiple areas of cancer research.