Pipeline

August 6, 2018

Company	Drug/Device	Medical Condition	Status
Clover Biopharmaceuticals, Inc.	SCB-808	rheumatoid arthritis (RA) and other autoimmune diseases	Phase I trial initiated
Arcus Biosciences, Inc.	AB154	anti-TIGIT antibody	Phase I trial initiated
CeraPedics	P-15L Peptide Enhanced Bone Graft	transforaminal lumbar interbody fusion (TLIF) surgery	Phase I trial initiated enrolling 364 subjects
BioLineRx Ltd.	AGI-134	patient-specific tumor neoantigens	Phase I/IIa trial initiated
Avelas BioSciences, Inc.	AVB-620	primary, non-recurrent breast cancer undergoing surgery	Period II, Phase II trial initiated enrolling 31 subjects
Biohaven Pharmaceutical Holding Company, Ltd.	trigriluzole (BHV-4157)	mild-to-moderate Alzheimer’s disease (AD)	Phase II/III trial initiated enrolling 292 subjects
Kala Pharmaceuticals, Inc.	KPI-121 0.25%	dry eye disease	Phase III trial initiated enrolling 900 subjects
GE Healthcare and Lantheus Holdings, Inc.	Flurpiridax	coronary artery disease	Phase III trial initiated enrolling 650 subjects
Progenics Pharmaceuticals	Azedra	adult and pediatric subjects 12 years and older with iobenguane scan positive, unresectable, locally advanced or metastatic pheochromocytoma or paraganglioma who require systemic anticancer therapy	NDA approval granted by the FDA
United Therapeutics Corporation	Remodulin	pulmonary arterial hypertension (PAH)	NDA approval granted by the FDA
Sensus Healthcare, Inc.	SRT-100+	non-melanoma skin cancer and keloids	510(k) clearance granted by the FDA
Modulated Imaging	Clarifi Imaging System	peripheral vascular diseases, diabetic foot ulcers, burns, skin flaps and chronic wounds	510(k) clearance granted by the FDA
Daiichi Sankyo Company, Ltd.	quizartinib	relapsed/refractory FLT3-ITD acute myeloid leukemia (AML)	Breakthrough Therapy Designation granted by the FDA
Armagen Inc.	GT-184	Mucopolysaccharidosis type IIIA (also known as Sanfilippo Syndrome A or MPS IIIA)	Orphan Drug Designation granted by the FDA
Endomag	Magtrace	breast cancer	PMA granted by the FDA
Hologic, Inc.	Panther Fusion GBS assay	Group B Streptococcus (GBS)	Clearance granted by the FDA
Shionogi & Co., Ltd.	Mulpleta (lusutrombopag)	thrombocytopenia in adult patients with chronic liver disease (CLD) who are scheduled to undergo a procedure	Approval granted by the FDA
Roche	cobas	cervical cancer	Approval granted by the FDA
Indivior PLC	PERSERIS	schizophrenia	Approval granted by the FDA