Pipeline

May 13, 2019

Company	Drug/Device	Medical Condition	Status
Xencor, Inc.	XmAb23104	advanced solid tumors	Phase I trial initiated
Shattuck Labs, Inc.	SL-279252 (PD1/OX40L)	advanced solid tumors and lymphomas	Phase I trial initiated
Alector, Inc.	AL002	Alzheimer’s disease	Phase Ib trial initiated
VivaQuant	RX-1 Rhythm Express	cardiac arrhythmias	510(k) clearance granted by the FDA
Imperative Care, Inc.	ZOOM Aspiration System	ischemic stroke	510(k) clearance granted by the FDA
LENSAR, Inc.	LENSAR Laser System with Streamline IV	micro radial incisions to optimize outcomes of refractive cataract procedures	510(k) clearance granted by the FDA
BioLineRx Ltd.	AGI-134	solid tumors	IND approval granted by the FDA
Phoenix Tissue Repair, Inc.	PTR-01	recessive dystrophic epidermolysis bullosa (RDEB)	Fast Track designation granted by the FDA
Savara, Inc.	Molgradex	autoimmune pulmonary alveolar proteinosis (aPAP)	Fast Track designation granted by the FDA
Concept Medical, Inc.	MagicTouch Sirolimus drug-coated balloon (DCB) catheter	coronary in-stent restenosis (ISR)	Breakthrough Device designation granted by the FDA
Vertex Pharmaceuticals, Inc.	KALYDECO (ivacaftor)	cystic fibrosis (CF) in children ages six months to less than 12 months	Approval granted by the FDA
AbbVie, Inc.	Mavyret (glecaprevir and pibrentasvir) tablets	six genotypes of hepatitis C virus (HCV) in children ages 12 to 17	Approval granted by the FDA
Medtronic plc	Attain Stability Quad MRI SureScan left heart lead	CRT treatment for heart failure	Approval granted by the FDA
Genentech	Kadcyla (ado-trastuzumab emtansine)	adjuvant treatment of people with HER2-positive early breast cancer (EBC) who have residual invasive disease after neoadjuvant taxane and Herceptin (trastuzumab)-based treatment	Approval granted by the FDA
Dr. Reddy’s Laboratories Ltd.	Testosterone Gel 1.62% (20.25 mg/1.25 g pump actuation)	testosterone deficiency	Approval granted by the FDA
Boston Scientific	VICI VENOUS STENT System	iliofemoral venous obstructive disease	Approval granted by the FDA