Pipeline

September 23, 2019

Company	Drug/Device	Medical Condition	Status
Clover Biopharmaceuticals, Inc.	SCB-313	peritoneal carcinomatosis	Phase 1 trial initiated enrolling subjects in China
Immunic	IMU-935	various inflammatory and autoimmune diseases	Phase 1 trial initiated
Benitec Biopharma	BB-301	Oculopharyngeal Muscular Dystrophy (OPMD)	Phase 1 trial initiated
Transgene	TG4050	HPV negative, squamous cell carcinoma of the head and neck (SCCHN)	Phase 1 trial initiated enrolling subjects that have received an adjuvant (first line) therapy in the UK and France
Transgene	TG4050	ovarian cancer	Phase 1 trials initiated enrolling subjects after first-line surgery and chemotherapy in France and the U.S.
Poxel SA	PXL065	Non-alcoholic steatohepatitis (NASH)	Phase 1b trial initiated enrolling 30 healthy subjects
Applied Molecular Transport	AMT-101	Ulcerative Colitis	Phase 1b trial initiated enrolling 20 adult subjects in Europe
NOXXON	NOX-A12 in combination with radiotherapy	Brain cancer	Phase 1/2 trial recruiting newly diagnosed patients with brain tumors who would not benefit from the current standard of care of chemoradiotherapy and whose tumors cannot be fully resected by surgery in Germany
REVOLUTION Medicines	RMC-4630 in combination with cobimetinib (Cotellic)	relapsed/refractory solid tumors harboring specific genomic mutations	Phase 1b/2 trial initiated
Momotaro-Gene	MTG201 in combination with PD-1 inhibitor nivolumab (Opdivo)	relapsed malignant pleural mesothelioma	Phase 2 trial initiated enrolling 12 subjects with malignant mesothelioma who have failed front-line systemic platin-based chemotherapy at Baylor College of Medicine in Houston, Texas
Pulmatrix	Pulmazole	Allergic Bronchopulmonary Aspergillosis (ABPA)	Phase 2 trial initiated enrolling 64 subjects with asthma
Graybug Vision, Inc.	GB-102	macular edema (ME) secondary to Diabetic Macular Edema (DME) or Retinal Vein Occlusion (RVO)	Phase 2a trial initiated enrolling 20 subjects at six centers in the U.S.
Alnylam Pharmaceuticals, Inc.	patisiran	transthyretin amyloidosis (ATTR amyloidosis) with cardiomyopathy	Phase 3 study initiated enrolling 300 adult subjects with ATTR amyloidosis (hereditary or wild type) with cardiomyopathy
Apollo Endosurgery, Inc.	Polypropylene Suture-Anchor Assembly	pass and anchor suture in the gastrointestinal tract	510(k) Clearance granted by the FDA
Janssen	Erleada	metastatic castration-sensitive prostate cancer (mCSPC)	Supplemental New Drug Application granted by the FDA
Merck Eisai	Keytruda in combination with Lenvima	advanced endometrial carcinoma	Approval granted by the FDA
Xeris Pharmaceuticals	GVOKE (glucagon) injection	severe hypoglycemia	Approval granted by the FDA