Trial Information

Summary: COG #AEWS0331: European Ewing Tumour Working Initiative of National Groups Ewing Tumor Studies 1999 (EURO-E-W.I.N.G. 99)

You are/your child is being asked to take part in this study because you have/your child has a type of cancer called Ewing sarcoma that has metastasized (spread) to the lung or pleura (membrane around the lungs). 

The primary purpose of this study is to compare standard drug therapy followed by whole lung irradiation versus standard drug therapy followed by high-dose, drug therapy and transplant (replacement) of peripheral blood stem cells (immature cells that can become red blood cells, white blood cells and platelets). Secondary purposes are:
1. To see if there is genetic information in the tumor cells that may help researchers predict how a patient will respond to therapy.
2. To see if there are any microscopic tumor cells left in the bone marrow after treatment and to find out if this has any effect on the outcome of the treatment.
3. To evaluate the feasibility, toxicity, and response to vincristine, ifosfamide, doxorubicin, etoposide (VIDE).
4. To evaluate the feasibility and toxicity of vincristine-actinomycin D-ifosfamide (VAI) and busulfan-melphalan (Bu-Mel).
5. To evaluate event free survival and overall survival by prognostic group analysis.

If you/your child receive standard therapy plus whole lung radiation, treatment will last about 11 months. If you/your child receive standard therapy plus high-dose plus transplant, treatment will last 6 to 8 months. After treatment and active monitoring have been completed, your/your child’s medical condition will be followed for up to ten years after the study closes to new subjects.

Patient Inclusion/Exclusion Criteria:

- See http://clinicaltrials.coh.org for additional information.

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Trial listings updated: October 6, 2008 at 3:02:28 PM