Springfield Clinic is a multi-specialty private practice limited partnership clinic servicing a large area of central Illinois. There are over 170 physicians serving as a referral source for investigational trials. Springfield Clinic research activities are provided oversight by a group of peer investigators who assure compliance with good clinical practice guidelines, compliance with applicable federal laws and review investigator training.

Springfield Clinic has interest in conducting trials in the areas of rheumatoid arthritis, osteo-arthritis, osteoporosis, lupus, infectious diseases, oncology, cardiology, neurology, urology, endocrinology, hepatitis C, skin disorders, multiple sclerosis, women’s health issues, erectile dysfunction, post-operative nausea, post-operative pain management, sepsis syndrome, macular degeneration, cataracts, and occupational health issues. New investigative areas are continually being added.

We have previous experience wit Abbott, Accorda, Alcon, Amgen, Aronex, Astra-Zeneca, Aventis, Basilea, Bausch & Lomb, Bayer, Berlex, Biogen, Boehringer Ingelheim, Bristol-Myers Squibb, Celgene, Centocor, Chiron, Covance, Cubicin, Eli Lilly, Endo-Pharmaceuticals, Genentech, Immunex, Incyte, Kendle, McGhan Medical Corporation, Medex, Medimmune, Medtronic, Mentor, Merck, MTRA, Novartis, NovoNordisc, Omnicare, OrthoBiotech, Ortho-McNeil, Parexell, Penninsula, Pfizer, PPD, Roche, Schering-Plough, Scios, Sequus Pharmaceutical Company, Serono SmithKline Beecham, Solvay, Target Research, 3-M, Theravance, Vicuron and Wyeth-Ayerst.

We have been the lead enrolling site in three multi-center trials in the area of Skin Infections and Sepsis. We have conducted trials in the areas of Atypical pneumonia, community acquired pneumonia, hospital acquired pneumonia, Intra-abdominal infections, Invasive Aspergillosis and candidiasis, osteomyelitis, shingles, febrile neutropenia, Hanta virus, complications of home infusion, rheumatoid arthritis and osteoarthritis, overactive bladder, erectile dysfunction, actinic keratosis, acute coronary syndrome, multiple sclerosis, chemo therapy induced anemia, metastatic breast cancer, diabetes, diabetic macular edema, HIV and Hepatitis C. We are familiar with multiple formats of electronic data capture as well as web-based training.

Our center has experience in both inpatient and outpatient trials. The main clinic is located one mile from St. John’s Hospital which has been recognized by U.S. News and World Report as one of the 50 best cancer hospitals in the nation. Springfield Clinic is accredited by AAAHC receiving the highest marks and maximum accreditation term allowed by that organization. The laboratory at Springfield Clinic is CAP and CLIA certified and full radiology service including CAT scan and MRI are available.

The Clinic has a dedicated research staff of 8 full time nursing professionals and full time document support staff that manage the day-to-day correspondence activities and other study regulatory requirements. The department also includes a Research Director who oversees the clinical activities as well as seeking new projects. The facility has conference rooms that are reserved for monitoring activities with telephone and Internet access. A copy and fax machine are also available for monitoring activities.

Edward L. Braud, M.D.
Medical Oncology Board Certified, Internal Medicine Board Certified
Dr Braud has been involved in clinical research since 1980. He has held the position of Associate Principle Investigator for the Central Illinois CCOP since 1987. He is listed as local PI on over 250 treatment and cancer control trials. Although his special interest is in bladder and prostate cancer, he has been involved with phase 2 and 3 trials for all types of cancers including hematologic neoplasms. He is a member of SWOG, ECOG, and NSABP. He is active in oncology affairs in both ASCO and ACCC.

Mary E. Bretscher, M.D.
Internal Medicine, Oncology, Hematology, Hospice & Palliative Medicine board certified
Clinical trial experience since 1993. Areas of interest include general oncology and palliative medicine.

David G. Dodwell, M. D.
Ophthalmology Certified
Clinical Trial Experience in devise and new drug development since 2002. Interested in diseases and treatments for retinal disorders of the eye. He specializes in disease and surgery of the retina and vitreous/laser treatment for diabetic retinopathy/macular degeneration. He was the first surgeon in central Illinois to perform laser treatment for premature eye diseases (retinopathy of prematurity), vitrectomy surgery for macular hole (a form of macular degeneration) and outpatient "no-stitch" retinal detachment surgery (pneumoretinopexy).

Anthony Firilas, M.D.
Board eligible, colon & rectal surgery
Clinical trial experience since 2004. Interested in outcomes research and new drug development as it related to his patient population.

Claude J. Fortin, M.D.
Neurology, Clinical Electroencephalography & Neurophysiology, Neuro Rehabilitation, Board Certified
Clinical Trial Experience in drug development since 1995. Interested in migraine headaches, ischemic stroke patients, epilepsy, and pain management. Special interests include electrodiagnostic medicine; sleep medicine, medical acupuncture, and pain management.

Donald R. Graham, M.D.
Internal Medicine and Infectious Disease Certified
Clinical Trial Experience in biological agents and drug development since 1977. Interested in Home Care complications (nosohusial infections), Sepsis Syndrome, Resistant Organisms, Fungal Infections, Catheter-related Infections, hepatitis C, Community Acquired and Nosocomial Pneumonia, Skin and Skin Structure Infections, Diabetic Foot Infections, Intra-abdominal Infections, C. difficile colitis, Osteomyelitis and prevention of Nosocomial Infections.

Shaun Hill, O.D.
Optometry
Interested in full scope optometric eye care with a special interest in family eye care including contact lenses, low vision services and sports vision. Dr. Hill holds an Illinois State License in both Optometry and Diagnostic/Therapeutic Optometric Pharmacology. He has received Visual Acuity Certification from Touchtone as well as ETDRS certification. He provides visual acuity and refraction examinations for all ophthalmologic clinical trials.

David R. Hoelzer, M.D.
Internal Medicine, Endocrinology and Metabolism Board Certified
Clinical Trial Experience in drug development since 1997. Interested in the care and treatment of Diabetic patients and their complications.

Karen L. Hoelzer, M.D.
Internal Medicine and Medical Oncology Board Certified
Clinical Trial Experience in drug development since 1986. Interested in diseases and treatments for patients with Breast Cancer. Extensive research experience through cooperative groups and industry trials.

Jeffrey Horvath, M.D.
Internal Medicine, Rheumatology Board Certified
Clinical trial experience since 2000 in rheumatoid arthritis and osteoarthritis studies including biologics. Interested in Rheumatic and Immunologic Diseases.

Judith P. Knox, M.D.
Dermatology Board Certified
Clinical trial experience in Actinic Keratosis. Provides comprehensive care of the skin for adults and children. Has a phototherapy unit (UVB/UVA) and an outpatient surgical suite. Performs procedures such as sclerotherapy, laser, Botox injections, and dermal fillers. Works in conjunction with a physician assistant who has expertise in treating common skin conditions such as acne and warts.

John Kwedar, M.D.
Ophthalmology Certified
Clinical Trial Experience in glaucoma drug and devise development. Interested in diseases of the eye including topical therapeutics and cataract surgery.

Douglas R. Leigh, M.D.
Internal Medicine and Infectious Disease Certified
Clinical Trial Experience in biological agents and drug development since 1996. Interested in Fungal Infections, HIV and Hepatitic C therapies.

Steven D. O’Marro, M.D.
Internal Medicine and Infectious Disease Certified
Clinical Trial Experience in biologic agents and drug development since 1987. Interested in HIV therapies, Fungal Infections, Sepsis Syndrome, Viral Infections, Community Acquired and Nosocomial Pneumonia, Hepatitis C, Skin and Skin Structure Infections and Intra-abdominal Infections.

Scott A. Mink, M.D.
Internal Medicine, Hematology and Medical Oncology Board Certified
Clinical trial experience since 2004. Special interests in Lymphoma, GI malignancies and lung cancer.

Randal J. Peterson, M.D., F.A.C.S.
Fellow American College of Surgeons, Ophthalmology Certified
Clinical Trial Experience in medical devices and drug development since 1980. Interested in ocular implant technology, treatments for cataracts and retinal vascular occlusions.

Michael A. Pick, M. D.
Internal Medicine and Rheumatology Board certified
Clinical trial experience in new drug development since 1996. Interested in Adult and Pediatric Rheumatology and Osteoporosis.

Mary O. Polk, M.D.
Internal medicine and Pulmonology Board certified
Clinical trial experience since 2004. Interested in sleep medicine and pulmonary medicine.

Randolph Wm. Roller, M.D.
Obstetrics, Gynecology Board certified
Clinical trial experience since 2004. Interested in contraception, perimenopause; menopause; estrogen therapy, osteoporosis, and bladder dysfunction.

David A. Roszhart, M.D.
Urology Board Certified
Clinical trial experience since 2004. Special interest in impotence, stones, incontinence and fistulas, prostate cancer, and general Urology. New treatment modalities in his armentarium include TVT for SUI, green light laser (KTP) for BPH, seed implants for prostate cancer and no scalpel vasectomy.

Kenneth R. Sagins, M.D.
Internal Medicine and Pediatrics board certified
Clinical trial experience since 2004. Interested in diabetes treatment options as well as other pediatric and primary care treatment options.

Mark A. Savage, M.D.
Family Practice board certified
Clinical trial experience since 2004. Interested in erectile dysfunction, diabetes treatment options as well as other primary care treatment modalities.

Mark A. Stern, M.D.
Internal medicine and Rheumatology board certified
Clinical trial experience in new drug development since 1996. Interested in Adult and Pediatric rheumatology and osteoporosis. ISCD clinical densitometry certification.

Osvaldo H. Wesly, M.D.
Internal Medicine, Hematology and Oncology Certified
Very broad bench and Clinical Trial Experience with Biologic Response Modifiers and Tumor Immunology as well as new drug development since 1982. Very interested in Bone Marrow / Stem Cell Transplantation, Immunemodulation, Graft versus Leukemia (GvL), Graft vs Host Disease, Lymphomas and Leukemias. Interested as well as Multiple Myeloma and other hematologic abnormalities. Solid tumor interests include Small Cell and Non-Small Cell Lung Cancer, Colon Cancer and other solid organ tumor diagnosis and treatments. Also with an interest in pain management, chemotherapy-induced toxicities and complications, neutropenia, and anemias both of chronic disease as well as chemotherapy or disease induced. Other disease or therapeutic manifestations / toxicities or innovative treatment or diagnostic approaches for the hematology / oncology patient would be of interest.

Donald L. Yakel, Jr., M.D.,
Internal Medicine and Cardiology Certified
Clinical Trial Experience in device and drug development since 1998. Interested in cardiac stent technology, anticoagulation therapies, hyperlipidemia, C-reactive Protein analysis and hypertension therapies.

Patient population is familiar with new therapies and eager to embrace new treatment options. Springfield Clinic has been providing care to Central Illinois since 1939 and has an excellent reputation in the area for providing quality health care.

Local Commercial IRB provides 10-14 day turnaround from protocol submission to approval. Local IRB (50 mile radius) is required for all in patient protocols. Out patient protocols can utilize the services of a central IRB.

CenterWatch is listing the following trials that are actively recruiting patients at this center.

• A Phase 2 study comparing rituximab plus sargramostim to rituximab monotherapy for treatment of relapsed, follicular B-cell lymphoma.

For more information, please contact:

Beth Wayant
Director of Research
Springfield Clinic, LLP
1025 South Seventh
Springfield, IL 62703 USA
Phone: 217-527-4745
Fax: 217-527-4747
E-mail:

If you are interested in contacting this center to discuss placing a clinical trial there, please complete and send the E-mail form below. A representative from the research center will then follow up with you.

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Last updated on June 20, 2008