The Bernstein Clinical Research Center has been conducting clinical research studies since 1969. Our Center has conducted over 500 clinical trials in the adult and pediatric patients and we have contributed to the development of new therapies for asthma, allergic rhinitis and chronic obstructive pulmonary disease (COPD). Our center has also conducted non-respiratory clinical trials for dermatological disorders (e.g., urticaria, hereditary angioedema, atopic dermatitis) migraines, hypertension and gastroesophageal reflux disease (GERD).

Our physician investigators are board certified internists and allergists, and serve on the faculty of the Division of Allergy/Immunology at the University of Cincinnati. They have published hundreds of clinical research articles in peer reviewed journals, and are invited to speak at national and international medical meetings.

The clinical research staff is highly trained and experienced. The center is staffed by four certified clinical research coordinators (CCRC). The study research team includes a nurse practitioner, a former critical care nurse , a registered respiratory therapist and other well trained clinical research professionals.

The Clinical Research Center conducts Phase I, II, III, and IV clinical trials for many large and small pharmaceutical companies. Our research center has gained a reputation for excellence in source documentation, complete case report forms and rigorous attention to detail. For years, our staff has built a reputation for consistently meeting randomization goals with qualified subjects. Due to rigorous and careful screening, our Center has enjoyed high completion rates with minimal numbers of screen failures. The Bernstein Clinical Research Center is able to work with centralized Institutional Review Boards. We have successfully completed many sponsor and FDA audits.

The Bernstein Clinical Research Center facility meets all regulatory requirements of ICH/GCP and FDA . Our staff is IATA certified for lab shipment.

• 6000 square foot, state-of-the-art facility equipped to do Phase I, II, III and IV clinical trials
• Phase I Unit (16 beds)
• Private rooms for conducting the Informed Consent Form Process
• 3 locked and secure drug storage facilities equipped with a Refrigerator & -40° Freezer
• Onsite archiving locked storage facility
• Private study interview/exam patient rooms
• Patient Lounge for 4, 12 hour studies
• Private space for monitors and audits
• Dedicated and secure space for research staff
• Skin testing rooms
• Laboratory specimen processing area, refrigerated centerfudge, -30° Freezer
• Electrocardiogram & Holter monitoring room
• Chest X-Ray and processing equipment
• Stadiometer (Pediatric trials)
• Wireless internet and modem
• Access to copiers, fax machines and telephones
• Rigorous OSHA requirements and training for all clinical research staff
• Detailed SOP’s and job descriptions for clinical research staff
• Crash cart and defibrillator equipment

Respiratory Clinical Trials

• Pulmonary Function equipment and DLCO
• Exercise Induced Asthma Challenge equipment and room
• Perform specialized Methacholine and challenge testing
• Fractional Expired Nitric Oxide Test (ENO)
• NIOSH approved instructor

I. Leonard Bernstein, MD, FACP
Dr. I. Leonard Bernstein is currently Clinical Professor of Medicine and Environmental Health at the University of Cincinnati College of Medicine. He has a national and international reputation for his clinical expertise and research in the field of environmental allergens, occupational/immunologic lung disease, hypersensitivity aspects of reproductions, and novel pharmacologic approaches to the treatment of asthma. Dr. Bernstein received his MD degree at University of Cincinnati and is board certified in Internal Medicine and Allergy-Immunology. He has served on editorial boards and as a consultant reviewer for sixteen medical journals and has been on numerous advisory committees for the NIH, FDA, NSF and AMA. He was chairman of the pulmonary/Allergy Drug Advisory Committee of the FDA from 1988 until 1992. He was chairman of the Pulmonary Allergy Drug Committee of the U.S. Pharmacopia from 2000 to 2005 and he currently represent the state of Ohio for the USP Convention, which extends from 2005 to 2010. He is a member of fourteen professional societies and a fellow of the American Academy of Allergy, Asthma and Immunology and the American College of Physicians. He was president of the American Academy of Asthma, Allergy and Immunology in 1982 and still serves on various committees of that organization. His publications include 30 book chapters, co-authorship/co-editorship of 4 books and over 300 papers in peer review journals.

David I. Bernstein, MD, FACP, CCI
David Bernstein, MD, is Professor of Clinical Medicine at the University of Cincinnati School of Medicine in Cincinnati, Ohio and is a DIA certified investigator. He is also director of the Allergy Diagnostic Laboratory, Division of Immunology and Director of the University Hospital Allergy Clinic. Dr. Bernstein is co-director of the Allergy Research Laboratory and the Allergy and Immunology Fellowship Training Program. Dr. Bernstein earned his medical degree from the University of Cincinnati College of Medicine and completed his residency in Internal Medicine at the Cleveland Clinic Hospital. He then received training in Allergy and Immunology at Northwestern University Medical School in Chicago, Illinois. Dr. Bernstein is board certified in Internal Medicine, Allergy-Immunology and Diagnostic Laboratory Immunology. He has authored and co-authored over 100 publications in peer-reviewed medical journals as well as numerous reviews and book chapters. He has received federal funding to study occupational asthma and environmental determinants of allergy and asthma in children.

Jonathan A. Bernstein, MD, FACP, CCI
Dr. Jonathan A. Bernstein is a Professor of Clinical Medicine in the Department of Internal Medicine, Division of Immunology/Allergy Section at the University of Cincinnati Medical Center, Director of the Veterans’ Administration Hospital Allergy Clinic and Allergy Laboratory and Director of Clinical Research for the Division of Immunology. Dr. Bernstein is actively involved in clinical and translational research, in addition to pharmaceutical research, patient care and teaching. His current research involves the investigation of indoor environmental determinants in the workplace and home that cause or aggravate asthma and rhinitis and investigation of genetic markers that could identify susceptible populations to these exposures. His publications (see curriculum vitae) reflect his interest in this area. Dr. Bernstein has extensive experience conducting clinical therapeutic trials and is a DIA certified investigator. Dr. Bernstein has published over 90 peer reviewed articles, clinical reviews and chapters on a variety of allergic disease topics.

Sub-Investigators:

Sherry Stanforth, RN, MSN, CNP
Nurse Practitioner and works as a Clinical Research Coordinator

Carol J. Abbott, RN, MSN, CNP

Cheryl Bernstein, RN, BSN, CCRC
Director of Clinical Research Center – 24 years experience

Karen J. Murphy, BS, RRT, CCRC
Senior Clinical Research Department Supervisor – 19 years experience

Denise M. Pohlman, CMA, GXMO, CCRC
Senior Certified Clinical Research Coordinator – 10 years experience

Brian P. Berendts, RN, BSN, CCRC
Senior Certified Clinical Research Coordinator – 7 years experience

Patrick Reilly, EMT-P
Clinical Research Coordinator II – 2 years experience

Kayleigh Carter, MA
Clinical Research Coordinator I

CenterWatch is listing the following trials that are actively recruiting patients at this center.

• Calling all Asthmatics
• Do You Have Asthma Associated with GERD (Heartburn)
• Do You Have COPD (Chronic Obstrcutive Pulmonary Disease), or Bronchitis?
• Do You Suffer From Asthma?
• Does Your Child Have Allergies All Year Long??

For more information, please contact:

Cheryl K. Bernstein, RN, BSN, CCRC
Bernstein Clinical Research Center, LLC
8444 Winton Road
Cincinnati, OH 45231 USA
Phone: 513-931-0775 ext 2
Fax: 513-728-4751
E-mail:

If you are interested in contacting this center to discuss placing a clinical trial there, please complete and send the E-mail form below. A representative from the research center will then follow up with you.

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Last updated on August 21, 2008