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Massachusetts General Hospital |
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Center Overview
The Massachusetts General Hospital has a long, rich, and diverse tradition of excellence in clinical research that continues to expand today. The extensive resources for training clinical investigators and performing top quality translational investigation include: An integrated full service primary, secondary, and tertiary care hospital network with access to large numbers of both local patients with common diseases and national and international patients referred for evaluation of rare disorders, over 600,000 square feet of research space, and a diverse population of thousands of basic and clinical scientists studying topics ranging from very basic molecular biology to direct patient management.
The MGH Clinical Research Program (CRP) was established to improve the environment for clinical investigation at the MGH through academic enrichment programs and direct support services, creating a culture in which all forms of clinical research can flourish. Its mandate is to:
- Enhance bench to bedside research
- Train clinical investigators
- Increase clinical trial activity
- Support outcomes research and disease management
- Coordinate the MGH's efforts with those of Partners HealthCare System and Harvard Medical School
The CRP serves as the institutional infrastructure that encourages and supports its physician scientists by serving as an interface between clinical investigators and sponsors of clinical trials and outcomes research. We work to:
- Explore preferred relationships with pharmaceutical and biotech companies
- Link industry to physicians for consulting, advisory board seats, and trials
- Provide outcomes and disease management expertise
- Support the administration of clinical trials
- Negotiate master clinical trial agreements
The CRP provides a high level of clinical trial services to help investigators compete and meet the demands on industrial sponsors. Services to PIs include:
- Assistance with the IRB application
- Preparation and negotiation of budgets
- Contact facilitation
- Assistance in patient recruitment
- Data management support
- Assistance with strategy and proposal development for corporate-sponsored and investigator-initiated clinical trials
- Assistance with the development of large multi-center grant applications
In addition to its role as a facilitator, the CRP has developed and sponsored a series of educational courses and seminars for current and future investigators and study coordinators. These activities not only improve the quality of the investigators and study coordinators but also raise awareness within the institution about clinical research. Mentoring is available to young researchers by fostering collaborations with established investigators. New investigators are offered career advice and assistance in developing and conducting research studies.
Since communication plays a critical role within the research community, the CRP has developed an interrelated set of communication and clinical research tools: CRnet an on-line information source about clinical research at MGH; web-based query tools and patient data registries to characterize patient populations and assess clinical trial feasibility; software and databases for investigator-initiated patient data registries and disease management studies; and direct technical support for the clinical investigative community.
The Clinical Research Program provides the infrastructure necessary to support clinical research on an institution-wide basis. By fostering academic collaboration, effecting communication with industrial sponsors and promoting a focused and streamlined administrative process, the CRP is building a responsive culture conducive to clinical investigation.
Research Study Volunteer Program
RSVP for Health, the Research Study Volunteer Program, connects interested volunteers with researchers at the Massachusetts General & Brigham and Women’s Hospitals. Volunteers come from all walks of life and can be of any gender, age, ethnicity or racial background. Studies need both healthy volunteers and people with an illness or inherited disorder.
We invite you to sign up for RSVP for Health to be notified about studies of interest to you or your family. By enrolling, you agree to receive information about studies and then you can decide whether to participate. . . . Medical breakthroughs are made possible by incredible people like you, who are willing to volunteer for clinical studies to help determine if research ideas hold promise.
Register online at www.RSVPforHealth.partners.org or by phone 866-391-7030
Currently Enrolling Trials
CenterWatch is listing the following trials that are actively recruiting patients at this center.
- A Cross-Over, Double Blind Comparison of Tolterodine vs. Placebo Treatments for Nocturia (frequent night time trips to the bathroom) in Perimenopausal and Post Menopausal Women
- A Double-Blind, Placebo Controlled Study of Maca Root for the Treatment of Antidepressant-Induced Sexual Dysfunction in Females
- A Double-Blind, Placebo Controlled Study of Maca Root for the Treatment of Sexual Dysfunction Associated with the Treatment Regimen for Bipolar Disorder
- A Double-Blind, Placebo-Controlled Trial of Adjunctive Pramipexole, a Dopamine Receptor Agonist, for Treatment-Resistant Major Depressive Episodes
- A Double-Blind, Randomized, Pilot Study to Measure the Effect of Treatment Intensification with a Potent Integrase Inhibitor, Raltegravir (MK-0518), on the Level of Persistent Plasma Viremia below 50 copies/mL in Subjects on Protease Inhibitor- or Non-Nucleoside Reverse Transcriptase Inhibitor-Containing Regimens
- A Multicenter, Double-Blind, Randomized, Placebo-Controlled, Parallel-Group, Study with Three Fixed Doses of Aripiprazole in the Treatment of Children and Adolescents with Autistic Disorder
- A PET Study Examining the Doparminergic Activity of Armodafinil in Adults
- A Phase 2 Randomized, Double-Blind, Placebo-Controlled Study of the Effect of VIA-2291, a 5-Lipoxygenase Inhibitor, on Vascular Inflammation in Patients after an Acute Coronary Syndrome Event
- A Pilot Open Study of the Safety and Effectiveness of Lamotrigine for the Treatment of Mania in Youth ages 6-17 with Bipolar I, Bipolar II, and Bipolar Spectrum Disorders
- A Psychological Study of Fear Conditioning and Extinction in Schizophrenia
- A Randomized-Withdrawal Phase III Study Evaluating the Safety and Efficacy of CG5503 Extended- Release (ER) in Subjects with Painful Diabetic Peripheral Neuropathy (DPN)
- A six-week, randomized, double-blind, multicenter, fixed-flexible dose, placebo-controlled study evaluating the efficacy and safety of oral ziprasidone in outpatients with Bipolar I depression
- A5232: Optimizing Vaccine Responsiveness in HIV-1 and HCV Infections by Identifying Determinants of Responsiveness: A Pilot Study
- A5232: Optimizing Vaccine Responsiveness in HIV-1 and HCV Infections by Identifying Determinants of Responsiveness: A Pilot Study
- A5235: PHASE II, RANDOMIZED, PLACEBO-CONTROLLED, DOUBLE-BLIND STUDY OF MINOCYCLINE IN THE TREATMENT OF HIV-ASSOCIATED COGNITIVE IMPAIRMENT
- Aromatase Activity and Ovarian Growth Factors in Preovulatory Follicles
- Assessment of Cardiovascular Risk in HIV Patients
- Behavioral modifications and Lorcaserin for Overweight and Obesity Management in Diabetes Mellitus
A 52-Week, Double-blind, Placebo-controlled, Parallel-group Study to Assess the Safety and Efficacy of Lorcaserin Hydrochloride in Overweight and Obese Patients with Type 2 Diabetes Mellitus Managed with Oral Hypoglycemic Agent(s) - D-Cycloserine for the Enhancement of Exposure in Social Phobia
- Depression, DNA Damage and Telomeres: A Chronic Stress Model of Accelerated Aging
- Dose-response relationships between gonadal steroids and bone turnover in men
- Effect of 7 Days of Exogenous Pulsatile GnRH Treatment on the Pitoutary-Gonadal Axis in Hypogonadotropic Hypogonadal Subjects
- Effect of Race on Gonadotropin Responses to Short Term Negative and Positive Feeback Effects of Gonadal Steroids
- Effect of Race on Gonadotropin Responses to Short Term Negative and Positive Feedback Effects of Gonadal Steroids
- Effect of Varying Testosterone Levels on Insulin Sensitivity in Men with the Metabolic Syndrome
- Effect of Varying Testosterone Levels on Insulin Sensitivity in Normal and IHH Men
- Effects of Anorexia Nervosa on Peak Bone Mass
- Effects of Growth Hormone Administration on Cardiovascular Risk Markers in Men and Women with Cured Acromegaly
- Effects of supraphysiologic rhGH on bone metabolism in Anorexia Nervosa
- Eszopiclone for Sleep Disturbance and Nightmares in Post Traumatic Stress Disorder
- Fluoxetine in Pedriatric Body Dsymorphic Disorder
- Genetic Basis of Inherited Reproductive disorders
- Genetics of Dystonia
- Genotype and Phenotype of Brainstem Injury in Autism, Project IV: Gene-environment interactions in a population exposed to a teratogen associated with autism
- Improving Outcomes in Pharmacotherapy of Treatment Refractory Social Phobia
- Investigating the Genetics of Pediatric Bipolar Disorder: The MGH1000 Project
- Letrozole Treatment in Normal and GnRH Deficient Women
- Metabolic Alterations in Women with a History of Hypertensive Disorders of Pregnancy
- Metabolic Effects of Switching from Kaletra to Boosted Reyataz
- Neuroendocrine Factors in Adolescent Depression
- Open-Label Study of Invega for the Treatment of Mania in Children and Adolescents ages 6-17 with Bipolar I, Bipolar II, and Bipolar Spectrum Disorder
- Open-label Study of Quetiapine for Mania in Preschool Children 4 to 6
- Pain Responses in Patients with Chronic Pain
- Pharmacotherapy Relapse Prevention in Body Dysmorphic Disorder
- Physiologic Effects of IGF-1 in Adolescents with Anorexia Nervosa
- Pilot Treatment Study of Fluoxetine for Obsessive-Compulsive Disorder in Children and Adolescents with Bipolar Disorder
- Pituitary Contribution to the Decline in Gonadotropin Secretion with Age
- Pituitary Contribution to the Decline in Gonadotropin Secretion with Age
- Pituitary Contribution to the Decline in Gonadotropin Secretion with Age
- Recombinant Human Prolactin Treatment for Lactation Insufficiency in Mothers of Premature Infants
- RNS™ System Pivotal Clinical Investigation
- Role of FSH in Human Gonadal Development
- Role of Goandotropin Pulsations in the Reversal of Hypogonadotropic Hypogonadism
- Sleep and Learning Study
- STOP AF: A clinical study of the Arctic Front™ cryoablation balloon for the treatment of paroxysmal atrial fibrillation.
- The Effect of Prolactin on Lactation
- The Genetics of Polycystic Ovary Syndrome
- The oral contraceptive pill to treat premenstrual worsening of depression.
- The SETPOINT Study—A Randomized Study of the Effect of Immediate Treatment with Potent Antiretroviral Therapy versus Observation with Treatment as Indicated in Newly Infected HIV-1-infected Subjects: Does Early Therapy Alter the Virologic Setpoint?
- The Staging of Gastrointestinal Malignancies by Endosonography: A New Echoendoscope
- Ziprasidone for the Treatment of Generalized Anxiety Comorbidity in Patients with Bipolar Disorder
Contact Information
For more information, please contact:
Kay Ryan
Clinical Trials Specialist
Massachusetts General Hospital
Clinical Research Program
55 Fruit Street, LRH-2
Boston, MA 02114 USA
Phone: 617-724-5200
Fax: 617-726-5501
E-mail:
If you are interested in contacting this center to discuss placing a clinical trial there, please complete and send the E-mail form below. A representative from the research center will then follow up with you.
