Wake Research Associates, established in 1984, is a nationally recognized professional research organization specializing in conducting pharmaceuticals, devices and nutrition trials. Wake Research Associates is an independent research center based on 17 physicians’ multi-specialty private practice drawing from a current patient population of approximately 80,000. We are affiliated with two major hospitals within close proximity: Wake Medical and Rex Hospital. Our sleep lab, Wake Sleep has 12 patient beds and certified polysomnographic technicians.

Wake Research Associates is a unique and innovative resource for Phase I-IV clinical trials. Our site is known for effectively combining strategic business development and retention with high quality clinical research procedures. Our approach is uncompromising - each study conducted at our site is carefully planned and executed according to regulations with superior quality.

Our focus is on Phase I-IV research trials and pharmokinetics studies. As of 2007, Wake Research has successfully conducted more than 2,050 clinical trials.

We conduct our clinical trials to ensure timely completion as well as high-quality and accurate work. We continually exceed sponsor expectations of integrity, subject enrollment goals, and human protection in addition to expeditious delivery of accurate evaluable data. Wake Research consistency monitors its team and work performance seeking room for improvement and growth. Our goals include team collaboration to improve the care of our patients and aid in the rapid availability of new, cutting-edge treatments to our patients and the community.

Our therapeutic specialties include:

• Internal Medicine
• Gastroenterology
• Pulmonology/Immunology
• Cardiology
• Infectious Diseases
• Gynecology/Women's Health
• Rheumatology
• Urology
• Psychiatry
• Neurology
• Provocative Meal Studies
• Pain Management
• Medical Devices
• Rx to OTC Studies
• Dermatology
• Weight Management/Nutrition

We have conducted/are currently conducting studies for the following conditions:

Gastrointestinal Diseases Irritable Bowel Syndrome Gastro-esophageal Reflux Disease Erosive Esophagitis Heartburn Colorectal CA Screen Crohn's Disease Ulcerative Colitis Functional Dyspepsia Constipation Gastroparesis Provocative Meal Studies Anal Fissures General Medicine Chronic Bronchitis Osteoarthritis Insomnia Smoking Cessation Sinusitis Back Pain Chronic Pain Management Gout Diabetes Diabetes 2 Asthma COPD Obesity Overactive Bladder Migraine Hypertension Hypercholesterolemia Fibromyalgia Healthy Volunteers

Women's Health Premenstrual Syndrome Vaginal Atrophy Sexual Dysfunction (women) Premenstrual Dysphoric Disorder Contraception Hormone Replaement Therapy Uterine Fibroids Osteoporosis Urinary Tract Infection Breast Pain Genital Warts Hot Flash Endometriosis Men's Health Premature Ejaculation Prostate Cancer prevention Rapid Ejaculation Psychiatry Anxiety Panic disorder Dermatology Acne Psoriasis Hyperhydrosis Rosacea Actinic Keratosis

We have worked with the following sponsors:
Pharmaceutical Companies: Glaxo-Wellcome, Bristol Myers, Genetics Institute, G.D. Searle Pharmaceutical, Otsuka Pharmaceutical, Tap Pharmaceutical, Kabi Pharmaceutical, RW Johnson, Merck Pharmaceutical, Astra Merck, Janssen Pharmaceutical, Wyeth Pharmaceutical, Ciba Geigy, Eli Lilly, Upjohn, Schering Plough, Hoffman-LaRoche, Gilead, Bayer, Boehringer Ingelheim, KOS Pharmaceuticals, Parke-Davis Pharmaceuticals, Smith-Kline Beecham, Takeda America, Abbott Pharmaceutical, Pfizer, Merck Pharmaceutical, Novartis, Targacept, ALZA, Purdue Pharma, McNeil, Allergan, Pain Therapeutics, Sanofi-Synthelabo, Axcan, AstraZeneca, Centocor, Neurocrine Biosciences, Pharmacia, Berlex, Barr Research, Inspire, Santarus, Elan, Celgene, Celltech, Acambis, Braintree

CRO's: ClinTrials, Quintiles, PPD-Pharmaco, Kendle, Kern McNeil, Premier Research, Scirex, IBRD, IBAH, Phoenix, Inc., InSite Clinical Trials, Bio Pharmaceutical, Parexel, Paragon, ICON, PRA, Dertech, TKL, AAI, Medpace, Kendall, Iveresk

Wake Research Associates is focused on the needs of both patient welfare and the growth of pharmaceutical research and development.

Our site facilities include:

• Secured Investigational Drug Storage
• Certified Endoscopy Unit with 5 suites and recovery
• Certified Diagnostic Laboratory
• X-Ray Department with Bone Densitometer and Ultrasound Unit (3) and
• Certified Mammography Unit
• Nuclear Medicine, heart station, EKG, treadmills, Holter Monitor, echo ECG
• Complete Pulmonary Unit with Spirometry, Peak Flow Monitoring & Survey System Plus
• Phase I and Pharmocokinetic Unit with infusion capabilities, private rooms, shower and TV
• Facilities for Provocative Meal Studies

Wake Research Associates is conveniently located 15 minutes from an international airport, minutes from major hotels, restaurants and shops as well as one of Raleigh's largest hospitals, Rex Hospital which is located just 0.5 miles from our site.

Our primary investigators are:

Charles Barish, MD
Area of expertise: Gastroenterology

Jonathan Flescher, MD
Area of expertise: Pulmonology

Wayne Harper, MD
Area of expertise: Internal Medicine

Susan Eder, MD
Area of expertise: Psychiatry

Adnan Nasir, MD, PhD
Area of expertise: Dermatology

Pouru Bhiwandi, MD
Area of expertise: Gynecology and Women's Health

Singar Jagadeesan, MD
Area of expertise: Neurology

Arvind N. Jariwala, MD
Area of expertise: Geriatrics and Internal Medicine

Our sub-investigators are:

Daniel Mollin, MD
Area of expertise: Internal Medicine

Bulent Ender, MD
Area of expertise: Gastroenterology

Philip Ashburn, MD
Area of expertise: Gastroenterology

Treva Tyson, MD
Area of expertise: Women's Health

Ella Grach, MD
Area of expertise: Executive Medical Director

Curtis Carlson, MD
Area of expertise: Internal Medicine

Seth A. Kaplan, MD
Area of expertise: Gastroenterology

Miroslav Gavazov, MD
Area of expertise: Internal Medicine

Research employees of Wake Research Associates include a variety of health professionals such as registered nurses, LPN, CMA and registered dieticians, all who assist investigators in conducting all phases of clinical trials. Our clinical staff members are certified in blood pressure monitoring, CPR, advanced cardiac life support, ECG, phlebotomy and bone density scans.

Wake Research Associates has 12 full-time coordinators, including 4 RN, 1 LPN, 1 CMA and 1 MA, Quality Assurance, Regulatory Specialist, and 3 dedicated patient recruiters. Four coordinators are certified by ACPR.

Wake Research Associates draws from a subject population of over one million. Our current database includes over 80,000 patients. Our patient volunteer database is constantly expanding and provides our Sponsors with more homogeneous research groups and thus, stronger clinical research trials. Wake Research Associates prides itself in rapid recruitment, consistently being a top enroller in majority of clinical trials.

CenterWatch is listing the following trials that are actively recruiting patients at this center.

• "I climax earlier than I want to."
• Actinic Keratosis
• Are you having difficulty losing weight?
• Are you having trouble controlling your weight?
• Are you no longer turned on when the lights turn off?
• Are you ready for a change?
• Are you tired? Tired of having heartburn at night which disrupts your sleep?
• Blood Sugar Control May be Just a Breath Away
• Chronic Constipation?
• Chronic Knee Pain?
• Do you feel Arthritis Pain with Every Step You Take?
• Do you have Crohn's Disease?
• Do you have Gout?
• Do you have Low Iron?
• Do you have Moderate to Severe Psoriasis?
• Do you have suffer from Crohn's Disease?
• Do you or someone you know suffer from Fibromyalgia?
• Do you or your partner have Genital Warts?
• Do you Suffer from Endometriosis?
• Do you suffer from Fibromyalgia?
• Do you suffer from seasonal allergies?
• Don’t let Crohn’s Disease keep you from your favorite activities
• Embarrassed by Acne?
• Fibromyalgia?
• Fibromyalgia?
• Frequent Heartburn Symptoms?
• Got Gout?
• Having to constantly rush to the bathroom due to the frustrating and often embarrassing symptoms of overactive bladder can cause sufferers a great deal of stress and anxiety
• Irritable Bowel Syndrome and Diarrhea?
• Is constipation weighing you down?
• Is Osteoarthritis knee pain putting you here… instead of here?
• Is Psoriasis causing you to be self-conscious?
• Just hanging in there with your Ulcerative Colitis?
• Research Study for Crohn's Disease
• Severe Pain during your Bowel Movements?
• Some pain medications can cause stomach uclers
• Struggling with Knee Pain?
• Suffer from Chronic Heartburn?
• Taking Daily Pain Medication?
• Tired all the time?
• Tired of having heartburn at night which disrupts your sleep?
• Tired of the Weight?
• Ulcerative Colitis?
• Women with Constipation predominant IBS

For more information, please contact:

Ella Grach, M.D.
Medical Director
Wake Research Associates
3100 Duraleigh Road, Suite 304
Raleigh, NC 27612 USA
Phone: 919-781-2514
Fax: 919-420-6067