Ranked among the best psychiatric research facilities in the world, the New York State Psychiatric Institute has contributed much to the strides taken towards achieving the goal of understanding and treating psychiatric disorders. Located on the Columbia-Presbyterian campus in Washington Heights, the Institute enjoys a rich and productive collaborative relationship with physicians in various disciplines and has 36 beds dedicated solely to psychiatric research. The Institute is home to distinguished researchers noted for their work in depression and suicide, schizophrenia, anxiety and child psychiatric disorders. Child psychiatry researchers helped bring attention to adolescent mental health and created a diagnostic tool (the DISC) to help school-based counselors assess teens for depression and related problems that may otherwise go undiagnosed.

PI scientists led the effort to create the first reliable system to specify inclusion and exclusion diagnostic criteria (DSM III) in psychiatry. The 2000 Nobel Laureate Eric Kandel was recognized for his work in elaborating on the cellular processes that underlie learning and memory, which has implications for major psychiatric disorders including Alzheimer's and for the normal decline in memory as we age.

The breadth and depth of research at Psychiatric Institute is seen below in an abbreviated form:

• Bipolar Disorder
• Depression in adolescents and adults
• Eating Disorders
• HIV and mental illness
• Homeless mentally ill and rehabilitation
• Lyme Disease: Cognitive and neuropsychiatric problems
• Obsessive-compulsive disorder (OCD)
• Post-partum depression
• Post-traumatic stress disorder (PTSD)
• Pathological Gambling
• Smoking Cessation
• Schizophrenia: Genetics, social problems
• Social Phobia
• Substance Abuse
• Winter depression or Seasonal Affective Disorder

Though world-renowned for its research, the Institute has used its expertise to enhance the delivery of services as well. Our experts are routinely contacted to provide consultations throughout the Office of Mental Health (OMH) system giving consumers and their physicians the benefit of up-to-the-minute, first-rate knowledge. Residents with serious psychiatric illnesses who live in the Washington Heights and Inwood communities are offered evaluation and treatment through the Washington Heights Community Service. The service consists of a 22-bed intensive care inpatient unit at Psychiatric Institute and two outpatient clinics.

To learn more about the New York State Psychiatric Institute, visit us on the web at www.nyspi.org.

The New York State Psychiatric Institute is located in upper Manhattan in the largely Dominican community of Washington Heights. The Institute is committed to meeting the mental health needs of the residents of Washington Heights and recruits volunteers from the community and throughout the five boroughs as well as New Jersey and parts of Connecticut.

CenterWatch is listing the following trials that are actively recruiting patients at this center.

• A Randomized Clinical Trial of Bupropion and Paroxetine for the Treatment of High-Risk Major Depressive Disorder.
• A randomized, double-blind, placebo-controlled, flexible dose study to evaluate efficacy and safety of Pramipexole IR (0.125-0.5 mg/day) versus placebo for 6 weeks in children and adolescents (age 6-17 inclusive) diagnosed with Tourette's Disorder according to DSM IV criteria
• Adults (age 18-65) suffering from chronic pain needed for inpatient/outpatient study
• Are you often irritable and explosive?
• Brain Imaging of Depression Using PET and Amphetamine
• Child/Adolescent Anxiety Treatment
• Children Helping Science
• Chronic Lyme
• Combining Antidepressants to Hasten Remission from Depression
• DHEA for Depression
• Dichotic Listening as a Predictor of Medication Response in Depression
• Do you have a fear of flying and live within commuting distance of New York City? We are doing a study to help people with these fears.
• Do you have a fear of heights and live within commuting distance of New York City? We are doing a study to help people with these fears.
• Do you have claustrophobia (afraid of closed-in places) and live within commuting distance of New York City? We are doing a study to help people with these fears.
• Do you have OCD and live in or near NYC?
• Double Blind Placebo-Controlled Study Exploring an Investigational Treatment for Generalized Anxiety Disorder in Outpatients.
• Drug Effects on Behavior: Shift-work Studies
• Duloxetine for Chronic Depression: a Double-Blind Study
• Fluoxetine and bupropion for the treatment of Major Depression in persons who drink alcohol.
• Have you AND a family member ever been DEPRESSED?
• Have you AND a family member ever been DEPRESSED?
• Have you AND a family member ever been DEPRESSED?
• Have you AND a family member ever been DEPRESSED?
• Healthy subjects needed for brain imaging study at Columbia University Medical Center.
• Healthy users of heroin (ages 21 - 45) needed for inpatient study
• Healthy users of heroin (men and women, age 21-45 yrs) needed for 4-8 week inpatient study of medication effects at the NY State Psychiatric Institute.
• Imaging the Serotonin System in OCD New York State Psychiatric Institute, New York City
• Interpersonal Psychotherapy for Borderline Personality Disorder
• Lexapro for Depression and Memory Problems
• Maximizing Treatment Outcome in OCD
  New York State Psychiatric Institute, New York City
• Multicenter, open-label, safety, tolerability, and pharmacokinetic study to evaluate single ascending doses and subsequent short-term administration of fixed doses of Desvenlafaxine succinate sustained-release tablets in the treatment of adolescent outpatients with Major Depressive Disorder
• Neurobiology of Depression and Antidepressants
• New Study: DHEA
• Normal, healthy volunteers (age 21-55) needed for outpatient study
• Outpatient study for women and men with mild, chronic pain
• Pediatric Mood Disorder Study
• PET Mapping of Serotonin Receptor Differences in Offsprings of Subjects With History of Unipolar Major Depression
• PET mapping of the serotonin receptor differences in unipolar major depression and suicidal behavior
• Pharmacotherapy of High-Risk Bipolar Disorder
• Predicting Response to Treatment with Antidepressants
• Provigil for Fatigue
• Research Volunteers: Healthy male and female MARIJUANA SMOKERS (age 21-45) needed to evaluate the effects of medications on mood and performance.
• Research Volunteers: Healthy men and women (age 21-45) to evaluate the effects of medication on mood and task performance.
• SAFE STEPS: Combined Treatment for Alcohol Dependent Women with PTSD
• Schizophrenia Research Studies
• Social Anxiety Disorder Treatment and fMRI
• SSRI Versus Bupropion in High-Risk Major Depressive Disorder
• The Neurochemistry and Neurocircuitry of Panic Disorder: Part II, Regional Brain 5-HT1A Receptor Status and Cerebral Blood Flow Response to Pentagastrin-Induced Panic
• Transcranial Magnetic Stimulation (TMS) in the Treatment of Major Depression
• Treatment of Negative Symptoms and Social Dysfunction of Schizophrenia with Transcranial Magnetic Stimulation (TMS)
• Treatment of Obsessive-Compulsive Disorder (OCD) with Transcranial Magnetic Stimulation (TMS)

For more information, please contact:

Dacia Morris
Public Information Officer
New York State Psychiatric Institute
1051 Riverside Drive, Unit 30
New York, NY 10032 USA
Phone: 212-543-5421
Fax: 212-543-6038
E-mail:

If you are interested in contacting this center to discuss placing a clinical trial there, please complete and send the E-mail form below. A representative from the research center will then follow up with you.

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Last updated on August 21, 2008