Lifetree Clinical Research was founded in 2003 by Lynn R. Webster, MD and Alice A. Jackson, RN. Lifetree Clinical Research® is a highly specialized development organization of dedicated research professionals focused on providing Drug Development Services, Clinical Trials Management and Site Services for the pharmaceutical and biotechnology industries. This organization seeks to achieve high medical standards, improve access to pain care, and educate all interested parties about many pain-related scientific and social issues.

We actively participate in and promote the growing need for better biopharmaceutical treatments by partnering with our clients in developing new therapies for ‘Growing a Better Quality of Life’.

Together, our logo and tag line ‘Growing a Better Quality of Life’ represents our strength and commitment to providing unparalleled service.

We commit each day to exceed your expectations. We hold ourselves to the highest standards of ethics and integrity which encourages repeat business and the development of long-term working relationships.

Lifetree Clinical Research® leads the way as a quality conscience investigative clinical research organization with investigators and staff combined clinical research experience of over 30 years. Our analgesic trials consistently achieve superior enrollment performance combined with low query rates. Lifetree investigators and staff have presented and published several abstracts and papers. Lifetree Clinical Research® Center offers expertise in the following areas:

Phase I Capabilities:

From our large database of healthy normal volunteers, Lifetree Clinical Research® can quickly enroll almost any specified population into Phase I studies. In addition, we provide rapid regulatory turnaround and shortened IRB approval times to meet your aggressive timelines.

1. Full PK/PD characterizations in plasma, urine, and CSF
2. Polysomnography in a sleep center
3. Safety/tolerability, optimal dosing schedules and MTD in target populations
4. Cardiac safety (QTc) evaluations

First in Human, Single Ascending Dose
Our team of physicians are on-site and therefore available for rapid response to our research subjects residing in our clinical research site for maximal safety.

First in Human and First in Patient, Multiple Ascending Dose (MAD)
We will help you determine a true Maximum Tolerated Dose (MTD) because we are able to maintain subjects on our Phase I unit for extended periods of time, if the study requires dosing to steady state with a long half-life compound.

Pharmacokinetic Studies
Studies that can be conducted include evaluation of healthy male and female subjects or special populations.

For whatever your Phase I needs, Lifetree Clinical Research® is ready to help.

Addiction Liability Capabilities:

Care of patients fighting substance abuse requires sensitivity to the issue and careful monitoring of outcomes.

Lifetree Clinical Research® has participated in several addiction medicine studies that required close monitoring, multiple PK draws, and lengthy in-patient stays. Lifetree Clinical Research® Center continues to grow in it’s commitment to researching all areas of addiction medicine.

Our highly trained research team is lead by Dr. Lynn R. Webster, board certified in pain medicine, anesthesia, and certified in addiction medicine. Dr. Webster has co-authored several recent abstracts regarding the Phase I studies that Lifetree Clinical Research® and Lifetree Pain Clinic have conducted.

Clinical Trial Management Services

• Project Management
• Study Design and Protocol Writing
• Site Recruitment and Management
• Participant Recruitment
• Site Monitoring
• Medical Monitoring
• Medical Writing
• Quality Assurance
• Developing Standard Operating Procedures (SOP’s) for Clinical Research Sites
• Investigator Meeting Planning

• On-Site Experienced MD Investigators
• On-Site Research Pharmacist
• On-Site Certified Research Coordinators
• On-Site Certified Cardiac Sonographers
• On-Site In-Patient Beds
• On-Site Anesthesia Support
• Documented Training Curriculum
• ACLS trained staff including RNs, Paramedics, and MAs.
• On-Site Quality Assurance
• State of the Art Monitoring Equipment
  • VS
  • Cardiac Telemetry
  • Echocardiography
  • ECG
  • Pulse Oximetry
  • Apnea
• Laboratory
• -40° Freezer
• Centrifuge-Ambient & Refrigerated

• Experienced pharma personnel with a track record of successful drug development
• Multiple drug approvals (US and EU)
  • Blockbuster brands in major pharma portfolios
  • Lifecycle management and brand extension products
  • Pediatric approvals
• Multiple INDs in pain and related areas
  • Full IND services:
    • Preclinical compound assessment
    • Evaluation of animal pharmacology
    • Preparation for first in human trials
    • Document preparation
• Broad range of regulatory experience
  • Labeling negotiations
  • drug approvals
  • advisory committees
  • EU approval process
  • Pediatric Rule Compliant program development
• DIRECT experience with current regulatory environment and current review division personnel
• Extensive Development AND Regulatory experience with:
  • ALTERNATIVE FORMULATIONS
  • ALTERNATE ROUTES OF DELIVERY
  • COMBINATION DRUG PRODUCTS
  • ABUSE LIABILITY ISSUES
  • PEDIATRIC ANALGESIC DEVELOPMENT

Lifetree Clinical Research® staff have aided in pioneering the development of new research models and the associated methodology that has been presented to the FDA and is now widely used in the analgesic drug development process. Lifetree understands the ever changing drug development market and the need for novel pain model development and progress. The Lifetree Clinical Research™ Center of Excellence is designed to support our knowledge, and the expertise in conducting innovative new model clinical trials.

The Lifetree Clinical Research® Center also incorporates the following features:

• On-site experienced Investigators
• 20+ overnight rooms. Our private rooms support the accuracy and integrity of the analgesic data collection process. Each patient room features an emergency call system and State of the Art telemetry monitoring system that allows patient data to be stored for up to 96 hours. This technology will continuously monitor the following:
  • Vital signs
  • ECG
  • Pulse oximetry
  • Apnea
  • Spacious operating room
  • Recovery area
  • On-site anesthesia support
  • Laboratory, complete with -40° freezer for PK storage
  • Safety equipment supported by BLS and ACLS research staff
  • Secured, temperature controlled, limited access drug room

Dr. Lynn Webster
Dr. Webster is Board Certified in Anesthesia, Pain Medicine and certified in Addiction Medicine. His private practice incorporates more than 2,000 chronic pain patients from a multi-state area. Dr Webster’s clinical research experience spans 20 years and Sponsors continually rely on his expertise during the protocol development process. Dr Webster has presented multiple abstracts, lectured at several pain conferences while maintaining a busy private practice of patients with the following chronic pain conditions:

• Smoking cessation
• Addiction medicine
• Neuropathic, nocieceptive pain
• Non-cancer pain
• Headache
• Low back pain
• Osteoarthritis
• Post-herpetic neuralgia
• Sleep disorders

Alice A Jackson RN, Chief Operating Officer: Ms. Jackson is Co-founder of Lifetree Clinical Research® and brings 15 years experience in clinical research to the Lifetree management team. Ms. Jackson has expertise in new site development, clinical research operations, business development, protocol development, and project management across multi disciplined teams. Ms Jackson has developed competency-based training for clinical research coordinators, written and trained multiple teams on industry accepted analgesic pain assessment process. Ms. Jackson has initiated, and trained on the importance and implementation of company SOP's. Ms Jackson aided in the development of the methodology for the post-operative bunionectomy model. Ms. Jackson presented as first author two recent abstracts regarding this new acute post-op pain model. First, at IASP in San Diego, August 2002, and then at the APS meeting in Chicago , March 2003. Ms. Jackson also participated in a presentation of study results for the bunionectomy model to the FDA in March of 2002.

Wayne C Croft MMS, CCRC, Executive Director has over 10 years clinical research experience in multi-therapeutic area’s. Wayne’s management roles includes site management, project management, data management and pharmacovigilance. Wayne’s expertise in protocol development and execution is instrumental in Lifetree’s success in meeting or exceeding our Clients expectations. Wayne provides oversight, training and direction to the Lifetree clinical research staff. Wayne is also responsible for site logistics, quality initiatives and adherence to Lifetree’s SOP’s.

Collectively, the staff at Lifetree Clinical Research® has more than 20 years combined research experience. Each coordinator is ACRP certified and adhere to all Lifetree company SOP's, ICH, FDA, HIPAA and OSHA Guidelines. Our company training program is competency based with documented records of training for each internal and external training courses completed. Each Lifetree staff member has completed BLS and ACLS certification. Lifetree centralized call center supports the efficiency of research subject recruitment to assure thorough screening and timely scheduling of study visits in one phone call. Once the information is collected, the recruitment staff enter subject data into our company database.

Salt Lake City and the surrounding area is home to more than 1,187,576 residents. Salt Lake City is known for it's compliant subject population. The demographics are predominately Caucasian, Hispanic and Native American.

Lifetree Clinical Research® is committed to providing unparalleled service to our clients. The integrity of the data is the daily focus of our research team. The broad base of research experience held by the company's leadership serves as the foundation for Lifetree's success.

CenterWatch is listing the following trials that are actively recruiting patients at this center.

• A Clinical Research Opportunity for People Suffering from Osteoarthritis of the Knee.
• A dose escalation study of NKTR-118 in patients with opioid-induced constipation (OIC).
• Clinical Research Study Opportunity Concerning Constipation
• Do you have difficulty falling asleep and staying asleep?
• Generalized Anxiety Disorder
• My shingles are gone. So, why does it still hurt?
• The pain is back.

For more information, please contact:

Alice A Jackson RN
Chief Operating Officer
Lifetree Clinical Research
3838 South 700 East, Suite 202
Salt Lake City, UT 84106 USA
Phone: 801-269-8200
Fax: 801-261-3341
E-mail:

If you are interested in contacting this center to discuss placing a clinical trial there, please complete and send the E-mail form below. A representative from the research center will then follow up with you.

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Last updated on February 25, 2008

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