The Center for Rheumatology and Bone Research - Rockville, MD
14955 Shady Grove Road, Suite 230
Rockville, MD 20850 USA
Phone: 301-942-6610
Fax: 301-942-7833
E-mail:
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Center Overview
Clinical Research Experience
Facility Description
Investigator Experience
Staff Expertise
Other Information
Currently Enrolling Trials
Contact Information

 

Center Overview

The Center for Rheumatology and Bone Research is a division of Arthritis and Rheumatism Associates, a twelve-physician Rheumatology practice. Clinical trials are completed in two locations: northwest Washington, D.C. and Wheaton, Maryland, a suburb of Washington. Administrative offices for the Center for Rheumatology and Bone Research are in Wheaton where support staff serves the needs of both our Maryland and District of Columbia sites.

The development of the Center stemmed from our desire to participate in clinical trials in a focused and well-managed setting, offering contracting companies high quality service while giving our patients access to new therapies. Our experience in conducting clinical trials began in 1982 and covers the broad range of rheumatology including the evaluation of new agents for RHEUMATOID ARTHRTTIS, OSTEOARTHRITIS, CHRONIC PAIN, BACK PAIN, OSTEOPOROSIS, SJOGREN'S SYNDROME, TENDONITIS, AND OTHER CONNECTIVE TISSUE DISEASES.

All of our physicians are board certified in Internal Medicine and Rheumatology. We have an active teaching affiliation with The George Washington University School of Medicine and Health Sciences and the University of Maryland School of Medicine. Members of the group are active in the American College of Rheumatology, the American College of Physicians, and the Association of Clinical Research Professionals.

Our rheumatology practice handles 30,000 patient visits annually (including 3,000 new patients) in four locations. We see patients from a wide geographic area that spans from Baltimore, Maryland to Fredericksburg, Virginia and from Harper's Ferry, West Virginia to Salisbury, Maryland. We are equipped with a full service, fully licensed laboratory and on-site x-ray facilities staffed with licensed radiation technologists. Our Osteoporosis Assessment Centers provide DEXA testing for bone mineral density measurement at three locations, and are capable of performing total body DEXA studies. In addition, we have an excellent physical therapy division with three full-time registered physical therapists.

Clinical Research Experience

The Center for Rheumatology and Bone Research has been conducting clinical research for twenty three years. We have participated in over two hundred clinical trials. Our main focus involves phase II, III, and IV protocols. Our clinical trial experience and therapeutic interests include:
  • Ankylosing Spondylitis
  • Acute and Chronic Back Pain
  • Bursitis
  • Chronic Pain
  • Epicondylitis
  • Internal Medicine
  • Osteoarthritis
  • Osteoporosis
  • Paget's Disease of Bone
  • Progressive Systemic Sclerosis (Scleroderma)
  • Psoriatic Arthritis
  • Rheumatoid Arthritis
  • Systemic Lupus Erythematosus
  • Sjogren's Syndrome
  • Tendonitis
  • Other Connective Tissue Diseases
The Center for Rheumatology and Bone Research has conducted studies for numerous pharmaceutical and biotechnology companies including:
  • Abbott Laboratories
  • Abgenex
  • Alexion Pharmaceuticals, Inc.
  • Almirall Prodesafarma, S.A.
  • Alza Pharmaceuticals
  • Amarillo Bioscience
  • Amgen, Inc.
  • Anika Therapeutics, Inc.
  • Astra Zeneca
  • Aventis
  • Ayerst Laboratories, Inc.
  • Bayer
  • Biogen, Inc.
  • Biovail Corp.
  • BMTS
  • Boehringer Ingelheim
  • Boehringer Mannheim
  • Boots Pharmaceuticals
  • Centocor, Inc.
  • Cheisi
  • Ciba-Geigy
  • Cipher Canada, Inc.
  • Cypress Bioscience, Inc.
  • Daiichi Pharmaceutical Company
  • Dimethaid
  • Dupont Pharmaceutical Company
  • EBI
  • Eli Lilly and Company
  • Endo Pharmaceuticals
  • Entropin
  • Fidia
  • Fresenius Hemocare, Inc.
  • F. Hoffman-LaRoche, Ltd.
  • Forest Laboratories, Inc.
  • Fujisawa USA, Inc.
  • G.D. Searle & Company
  • Genderm
  • Genentech, Inc.
  • Genomics Collaborative
  • Greenwich Pharmaceuticals
  • Hoechst Marion Russel
  • Human Genome Sciences, Inc.
  • Immunex
  • Janssen Pharmaceutical Products, L.P.
  • Knoll Pharmaceuticals
  • Lunar
  • Macrochem
  • Marion Merrill Dow
  • McNeil Consumer
  • MedImmune, Inc.
  • Merck & Company
  • Merckle GMBH
  • National Institute of Health
  • Novartis Pharmaceutical Corp.
  • NPS - Allelix Corporation
  • Ortho Biotech Products, L.P.
  • Ortho-McNeil Pharmaceutical, Inc.
  • Otsuka Maryland Research
  • Parke Davis
  • The Perdue Frederick Company
  • Pharmacia Corp.
  • Phytomedics, Inc.
  • Pfizer, Inc.
  • Procter & Gamble Pharmaceuticals, Inc.
  • Purdue Pharma, LP
  • R.W. Johnson
  • Regeneron Pharmaceuticals, Inc.
  • Riker
  • Roberts Pharmaceutical Corp.
  • Roche Laboratories
  • Roxane Laboratories
  • Sandoz
  • Sanofi Synthelabo, Inc.
  • Sanofi-Winthrop
  • Savient Pharmaceuticals, Inc.
  • Schering - Plough Research Institute
  • SCIOS, Inc.
  • Searle
  • Sepracor, Inc.
  • Shire US, Inc.
  • Snow Brand Milk Products Co., LTD.
  • Sterling Winthrop
  • Syntex
  • TAP Pharmaceutical Products, Inc.
  • Upjohn
  • Unither Pharmaceuticals, Inc.
  • University of Alabama
  • Wyeth
  • Wyeth-Ayerst
  • Zeneca Pharmaceutical
Our center has also conducted studies for several Contract Research Organizations including:
  • ABT Associates Clinical Trials
  • Barton and Polansky Associates, Inc.
  • B&B Clinical Innovations
  • Chiltern International, Inc.
  • C.L. McIntosh, Inc.
  • Clinimetrics
  • Clintirals, Inc.
  • C.G. Besselaar
  • Corning Pact
  • Covance
  • Corning Besselar
  • Global IQ
  • IBAH
  • IBRD/Rostrum
  • Innovex
  • Inveresk Research
  • Kendle
  • Medical Research Services
  • M.T.R.A.
  • Omnicare
  • Parexel International, Corp.
  • Pharmalink
  • Pharmanet, Inc.
  • PPD Development
  • PRA International
  • Premier Research
  • Quintiles, Inc.
  • Resource Solutions
  • RRI International, Inc.
  • Scirex
  • Stat Probe

Facility Description

Wheaton, Maryland Site:

Just minutes from the FDA in Rockville and the NIH in Bethesda, the research center in Maryland is a stand-alone clinical research facility located adjacent to our Wheaton rheumatology practice. It affords generous space for interviewing and examining patients and for clinical research associates to monitor the progress of protocols. The site is staffed with five Clinical Research Coordinators, an Assistant Coordinator and a Research Assistant. All coordinators are certified by the Association of Clinical Research Professionals upon eligibility.

District of Columbia Site

The research center located in downtown Washington, D.C. provides space for interviewing and examining patients and for clinical research associates to comfortably monitor the progress of protocols. The site is staffed with a dedicated Clinical Research Coordinator who is certified by The Association of Clinical Research Professionals.

Administrative Offices:

Located in Wheaton, Maryland and serving both sites, our administrative staff members include an experienced clinical research administrator, a patient recruiter, a research financial and regulatory specialist, and a quality assurance officer.

Investigator Experience

Herbert S.B. Baraf, M.D., F.A.C.P., F.A.C.R.
Managing Partner, Arthritis and Rheumatism Associates
Director of Clinical Research, Center for Rheumatology and Bone Research Medical Director, Maryland Site

Dr. Baraf serves as the Managing Partner of Arthritis and Rheumatism Associates. Since he founded the clinical research program in 1982, Dr. Baraf has served as the Director of Clinical Research for the Center for Rheumatology and Bone Research and the Medical Director of the Maryland Site. He is Clinical Professor of Medicine at the George Washington University School of Medicine and Clinical Associate Professor of Medicine at the University of Maryland School of Medicine. Dr. Baraf is a Fellow of the American College of Rheumatology and the American College of Physicians. He is a member of the Scleroderma Foundation of Greater Washington, the Rheumatism Society of the District of Columbia (where he served as president), and the Board of Directors of the Metropolitan Washington Chapter of the Arthritis Foundation.

Dr. Baraf received his B.S. from the University of Michigan, Ann Arbor, Mi. in 1969 and his medical degree from the State University of New York College of Medicine, Downstate Medical Center, Brooklyn, N.Y. in 1973. He completed his Internal Medicine training at the George Washington University Hospital in Washington, D.C. and a Fellowship in Rheumatology at Duke University Medical Center, Durham, N.C. He is Board Certified in Internal Medicine and Rheumatology.

Dr. Baraf has lectured before the American College of Rheumatology and is the author of several academic papers. He has presented work at national meetings of the American College of Rheumatology and the American Society of Clinical Research.

Norman S. Koval, M.D., F.A.C.P., F.A.C.R.
Chief, Division of Bone Research

Dr. Koval is an Associate Professorial Lecturer at the George Washington University School of Medicine and a Clinical Associate Professor of Medicine at the University of Maryland School of Medicine. He is a Fellow of the American College of Rheumatology and the American College of Physicians and a member of the National Osteoporosis Foundation, the Society for Clinical Densitometry, and the Rheumatism Society of the District of Columbia. Dr. Koval has a special interest in bone disorders and serves as a consultant to the pharmaceutical industry in this field. He serves as Chief of the Division of Bone Research for the Center.

Dr. Koval earned his undergraduate degree at the George Washington University in 1961 and his medical degree at the George Washington University School of Medicine in 1965. His Internship and first year of Residency were at D.C. General Hospital in Washington, D.C. His second and third years of Residency were conducted at the Veterans Administration Hospital in Washington, D.C. where Dr. Koval served as Chief Resident. He completed a fellowship program in Rheumatology and Immunology at Walter Reed Army Medical Center in 1973. Dr. Koval is Board Certified in Internal Medicine, and he was the first Board Certified Rheumatologist to serve in the United States Army.

David Borenstein, M.D., F.A.C.P., F.A.C.R.
Medical Director, District of Columbia Site

The District of Columbia site is directed by Dr. Borenstein, a former Professor of Medicine at George Washington University and the former Director of the Spine Center at George Washington who joined ARA in 1996. Dr. Borenstein is currently Clinical Professor of Medicine at the George Washington University School of Medicine in Washington, D.C. He is a Fellow of the American College of Physicians and the American College of Rheumatology and a member of the Rheumatism Society of the District of Columbia. Dr. Borenstein is one of only 250 physician members of the exclusive International Society for the Study of the Lumbar Spine. Nationally recognized for his expertise in osteoarthritis and in the diagnosis and treatment of disorders of the cervical and lumbar spine, he serves as a consultant to the pharmaceutical industry in these areas.

Dr. Borenstein received his A.B. at Columbia University in New York City in 1969 and his medical degree at The Johns Hopkins University School of Medicine in Baltimore, Md. in 1973. He completed his Internal Medicine and Rheumatology training at The Johns Hopkins Hospital. He is Board Certified in Internal Medicine and in Rheumatology.

Dr. Borenstein is co-author of "Low Back Pain: Medical Diagnosis and Comprehensive Management" and "Neck Pain: Medical Diagnosis and Comprehensive Management." He has lectured internationally.

Investigators:

Robert L. Rosenberg, M.D., F.A.C.R.

Dr. Rosenberg serves as the Laboratory Director and the Co-Director of the Osteoporosis Assessment Center for Arthritis and Rheumatism Associates. He is a Fellow of the American College of Rheumatology and member of the American Rheumatism Association and the Rheumatism Society of the District of Columbia where he is has served as President. Dr. Rosenberg is certified by the American Society of Densitometry. He lectures throughout the eastern United States on the clinical management of osteoporosis and arthritis.

Dr. Rosenberg completed a seven year combined program at the George Washington University and the George Washington University School of Medicine where he received his M.D. in 1971. Internship and the first year of Residency in Internal Medicine were completed at the University of Pittsburgh – Presbyterian University Hospital in Pennsylvania. Dr. Rosenberg then served as an Epidemic Intelligence Service (E.I.S.) Officer for the United States Public Health Service at the Center for Disease Control, Atlanta, Ga. Following his military service, Dr. Rosenberg completed his Medicine Residency and Fellowship in Rheumatology at the University of Tennessee Center for the Health Sciences, Memphis, Tennessee. He is Board Certified in Internal Medicine and Rheumatology.

Evan L. Siegel, M.D., F.A.C.R.

Dr. Siegel serves as the Physician Director of the Physical Therapy Department for Arthritis and Rheumatism Associates. He is a Fellow of the American College of Rheumatology and a member of the American College of Physicians and the Rheumatism Society of the District of Columbia. He has served as a member of the physician advisory panel of the Washington, D.C. Metropolitan Chapter of the Arthritis Foundation. He lectures frequently to physician colleagues and community groups on the management of arthritis and related disorders.

Dr. Siegel completed a seven-year combined Liberal Arts/Medical Education Program at Boston University where he received his M.D. from the School of Medicine in 1984. His lnternship and Residency were served at Montefiore Hospital and Medical Center, Bronx, NY. His Fellowship training was completed in a combined program at the New York University Medical Center and the Hospital for Joint Diseases, New York, NY. He is Board Certified in Internal Medicine and Rheumatology.

Emma DiIorio, M.D., F.A.C.R.

Dr. DiIorio serves as the Co-Director of the Osteoporosis Assessment Center for Arthritis and Rheumatism Associates. Dr. DiIorio is a Fellow of the American College of Rheumatology and a member of the American College of Physicians and the Rheumatism Society of the District of Columbia.

Dr. DiIorio received her B.A. from New York University, New York, NY, in 1983. She was a member of Phi Beta Kappa and a Magna Cum Laude graduate. She earned her Doctorate of Medicine at New York University School of Medicine where she was a member of Alpha Omega Alpha, the medical honor society. Her lnternship and Residency were served at the Mount Sinai Medical Center, New York, NY, and her Fellowship training in Rheumatic Diseases was completed at Baylor College of Medicine, Houston, TX. She is Board Certified in Internal Medicine and Rheumatology.

Alan K. Matsumoto, M.D., F.A.C.R.

Dr. Matsumoto joined Arthritis and Rheumatism Associates, P.C. in March 2002, after nine years as an Assistant Professor of Medicine, Division of Rheumatology, at The Johns Hopkins University School of Medicine, Baltimore, MD. In that capacity, as well as treating patients, Dr. Matsumoto directed the rheumatology teaching programs for medical residents at Johns Hopkins Hospital and Johns Hopkins Bayview Medical Center. He co-directed the Johns Hopkins Arthritis Website and served as an ad hoc reviewer for JAMA and Medicine. His research interests included the use of novel therapeutic agents for the treatments of rheumatic diseases. He is a Fellow of the American College of Rheumatology and a member of the American College of Physicians.

Dr. Matsumoto was awarded his B.S. degree from Stanford University in 1981 and his medical degree from the University of Illinois at Chicago in 1985, where he was elected to Alpha Omega Alpha, the medical honor society. His Internal Medicine Internship and Residency were served at the University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School, where in his final year he was Chief Resident at the Medical Center at Princeton. He completed his Fellowship training in Rheumatic Diseases at Johns Hopkins University School of Medicine in1993 where he was awarded a Howard Hughes Postdoctoral Fellowship for Physicians. Dr. Matsumoto is Board Certified in Internal Medicine and Rheumatology.

Werner F. Barth, M.D., F.A.C.P., M.A.C.R.

Dr. Barth recently joined Arthritis and Rheumatism Associates and the Center for Rheumatology and Bone Research after an illustrious career as the Chairman of the Section of Rheumatology at the Washington Hospital Center. He maintains a national reputation as a clinician and physician educator. Dr. Barth is an emeritus Professor of Medicine at the George Washington University School of Medicine, and he was the former Chairman of the Department of Medical Specialties at the National Rehabilitation Hospital.

Dr. Barth received his A.B. from Columbia University in New York City and received his M.D. from the Albert Einstein College of Medicine in the Bronx, New York. His diverse postgraduate training included rotations at Barnes Hospital in St. Louis, MO, the National Cancer Institute, NIH and the University of Washington in Seattle. After residency, Dr. Barth was an investigator in the Arthritis Branch of the National Institute of Arthritis and Metabolic Diseases for three years, and then served as Associate Professor of Medicine of the Department of Medicine and the Chief of the Arthritis Division at the University of Maryland in Baltimore before taking his position at the Washington Hospital Center.

Dr. Barth is a Fellow of the American College of Physicians where he has served as Governor of the DC chapter. In November, 2000 he will receive the Laureate Award for distinguished accomplishment in the field of medicine. Dr. Barth is a Master of the American College of Rheumatology. He is the author of over 75 journal publications and several textbook chapters. He is Board Certified in Internal Medicine and Rheumatology.

Joseph D. Croft, Jr., M.D., FACP, MACR

Dr. Croft is a cum laude graduate of Princeton University, Princeton, NJ. He received his medical degree from Cornell University, New York, NY. He completed his Internship and Residency at Strong Memorial Hospital in Rochester, NY where he was Chief Resident in Medicine and a Fellow in Rheumatology. He then spent two years as a Clinical Associate at the Dermatology Branch of the National Cancer Institute. Dr. Croft is currently a Clinical Professor of Medicine at Georgetown University School of Medicine and has been practicing Rheumatology in the Washington, DC area since 1969. He is Board Certified in Internal Medicine and Rheumatology and has been named an outstanding specialist in the field of Rheumatology by Washingtonian magazine, Washington Consumers' Checkbook and Best Doctors in America.

Dr. Croft's professional career has included service to many organizations. He is the past president of both the American College of Rheumatology and the Rheumatism Society of the District of Columbia. He has served on committees for the Medical Society of the District of Columbia, the FDA, the Arthritis Foundation and the Georgetown University School of Medicine. Georgetown University has honored him with their Outstanding Visit Award for Excellence In Teaching Medical House Officers in the Art and Science of Medicine and their Vicennial Medal. The American College of Rheumatology has honored him with the Paulding Phelps award for outstanding service on behalf of Clinical Rheumatology and the American College of Rheumatology. He has also been awarded the American College of Physicians Preceptorship of the Year for Community Based Teaching. In the fall of 2002 he was awarded the title of Master (MACR) by the American College of Rheumatology.

Robert J. Lloyd, M.D., FACR

Dr. Lloyd is a graduate of Providence College, Providence, RI and Georgetown University School of Medicine, Washington, DC where he was elected to Alpha Omega Alpha medical honor society and was the recipient of the Physiology and Biophysics award. He served his Internship, Residency and one year of Fellowship training at Georgetown University Medical Center. He completed his second year of Fellowship training at the Veteran's Administration Hospital, Washington, DC. He is a Clinical Associate Professor of Medicine at Georgetown University School of Medicine and is Board Certified in Internal Medicine and Rheumatology. Dr. Lloyd was recognized in Washingtonian magazine as an outstanding specialist in the field of Rheumatology, Washington Consumers' Checkbook and Best Doctors in America.

Dr. Lloyd has served on numerous committees of the Medical Society of the District of Columbia including the Chairmanship of the Rheumatology Section. He is a recipient of the Clinical Faculty Award from the Department of Medicine at Georgetown University School of Medicine and has also been honored with their Vicennial Medal. He has been a committed volunteer for the American College of Rheumatology and is currently a member of the Government Affairs Committee. In 2002, they honored him with the Paulding Phelps award for outstanding service on behalf of Clinical Rheumatology and the American College of Rheumatology. Dr. Lloyd has been engaged in the private practice of Rheumatology in the Washington, DC area for the past 27 years.

David P. Wolfe, M.D.

A native Washingtonian, Dr. Wolfe graduated Cum Laude from Amherst College, Amherst, MA where he received his BA in 1990. He received his Medical Degree from Georgetown University School of Medicine, Washington, DC, in 1995. Dr. Wolfe completed a residency in Internal Medicine and Pediatrics at Tufts University's Baystate Medical Center, Springfield, MA. While at Baystate, he was honored with the House Staff/Fellow Citation for Excellence in Teaching Award, given by the Tufts University School of Medicine, Class of 1998.

From August 1999 - June 2002, Dr. Wolfe was employed by the Chinle Comprehensive Health Care Facility (Chinle Hospital), of the Navajo Area Indian Health Service. During that time he served as a staff physician as well as the Medical Director of the Outpatient Department, and as Project Manager for an Outpatient Redesign and Expansion project. In July 2002, he received the Superior Administrative Service Award from the hospital.

In June 2004, just prior to joining Arthritis and Rheumatism Associates, P.C., Dr. Wolfe completed a Fellowship in Rheumatology at the University of Pittsburgh Medical Center, Pittsburgh, PA.

Dr. Wolfe will see patients in our DC and Chevy Chase locations. He has experience in all areas of Rheumatology, but has special interests in Fibromyalgia, Rheumatoid Arthritis and Osteoporosis.

Staff Expertise

All of our coordinators are certified by the Association of Clinical Research Professionals. The staff from both sites participates in joint weekly meetings that set policy, provide ongoing training, and facilitate our program of quality assurance.

Director:

    June Norris Fleming, CCRC

Clinical Research Coordinators:

    *Carol M. Spicher, LPN, CCRC
    *Elizabeth Dinges, RN, CCRC
    *Tara Cozzarelli, RN
    *Catherine Tran
    Maria Novella Papino
    Aundria Cosby, RN
    Crystal Hoven, RN
    Andrecia Mitchell, RN
    Krisztina Nagymarosi
Research Assistants:
    Toyia Johnson
    Bobbie Surratt
    Julia Dyer

Quality Assurance Officer:

    Sheila Delaughter

Financial-Regulatory Specialist:

    Patrick Comes, BA

(* Maryland Site Coordinators)

Other Information

Please visit the Profile Page for The Center for Rheumatology and Bone Research, Washington, DC, site:
www.centerwatch.com/pro495.htm

Please visit our Clinical Practice web site: www.washingtonarthritis.com

For patient inquiries, please call at (301) 942-6610.

Currently Enrolling Trials

CenterWatch is listing the following trials that are actively recruiting patients at this center.

Contact Information

For more information, please contact:

June Norris Fleming, CCRC
Clinical Research Administrator
The Center for Rheumatology and Bone Research - Rockville, MD
14955 Shady Grove Road, Suite 230
Rockville, MD 20850 USA
Phone: 301-942-6610
Fax: 301-942-7833
E-mail:

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    Last updated on February 25, 2008

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