Dr. David Margolin, the principal investigator, is a Board Certified Neurologist with 20 years experience in treating patients with Alzheimer’s disease, Parkinson’s disease and other neurological illnesses. He has conducted over 90 clinical trials in Neurology and Psychiatry. All studies are conducted at the Margolin Brain Institute, a state-of-the-art facility which houses Dr. Margolin’s private neurology practice and the clinical trials research.

We have been involved in clinical research for 11 years.

We focus on research phases: II through IV

Our therapeutic specialties include:
All neurological and psychiatric disorders, with special expertise in Alzheimer's disease and Parkinson's disease.

The sponsors we have worked with include:

Amgen, Inc. Bayer Corporation Biovail Corporation Boehringer Ingelheim Pharmaceuticals Bristol-Myers Squibb David Pharmaceuticals DuPont Merck Pharmaceutical Co. Eisai America, Inc. Eli Lilly and Company Forest Laboratories Fujisawa Research of America, Inc. G.D. Searle Glaxo Inc.

GlaxoSmithKline H. Lundbeck Hoechst-Roussel Pharmaceuticals Hoffman LaRoche Janssen Research Foundation Merck Research Laboratories Merz + Co. GmbH & Co. Miles Inc. Mitsubishi Pharmaceuticals Mylan Pharmaceuticals NeoTherapeutics, Inc. Novartis Pharmaceuticals

Parke-Davis Pharmaceutical Research Pentech Pharmaceuticals Pfizer, Inc. Pharmacia and UpJohn, Inc. Protodigm, Ltd. Sandoz Pharmaceutical Corporation Sanofi-Synthelabo Research Schwab GmbH & Co. Schwarz Biosciences Smith-Kline Beecham Corporation Takeda America TEVA Pharmaceuticals

The CROs we have worked with include:

Barton & Polansky Covance CroMedica IBIRD ICON Clinical Trials Ingenix Pharmaceutical Services Kendle Medex Clinical Trials Service

Paragon Parkinson’s Study Group PRA International Premiere Research Inc. Quintiles Pacific, Inc. SciRex The Hardardt Group Worldwide Clinical Trials

Facility Description

The Margolin Brain Institute, which opened in April, 2000, occupies 5,000 square ft. in a custom-designed, single story, state-of-the-art office building in Northeast Fresno. The staff utilizes a comprehensive, computerized, clinical trial data management system, which simultaneously records and organizes patient demographics, schedules patients according to individual study protocols, and tracks patient visits and procedures. The system runs on a Windows 2000 LAN network, which also supports all Microsoft Office 2000 programs.

David Ira Margolin, M.D., Ph. D.
Areas of Expertise:
Neurology - Alzheimer's, Parkinson's, Headache, Stroke, Seizure, Multiple Sclerosis, ALS, Pain and Head Injury
Psychiatry - Depression, Anxiety, Obsessive Compulsive Disorder, Adult Attention Deficit Disorder, Panic Disorder, Substance Abuse
Internal Medicine - Hypertension, Hyperlipidemia, Arthritis, Peripheral Vascular Disease, Weight Loss

J.J. Margolin, R.N., F.N.P.
Clinical Coordinator Supervisor
11 years experience in clinical research

In addition to J.J. Margolin, who has coordinated with Dr. Margolin on over 90 clinical trials during the past 11 years, there are 5 clinical coordinators on staff.

This site is the main neuroscience clinical trials center in Central California. This nine-county region has a population of about 3 million. Fresno County alone, with over 750,000 residents, is more populous than San Francisco County. The Central Valley's population of people 55 and older (199,000 in 1990) is expected to nearly double by the year 2010.

This site operates independent of any larger bureaucracy thus eliminating the administrative delays frequently encountered at institution-related sites. Contracts can be executed within 24 hours and the site is free to use the IRB of the sponsor's choice. Several study coordinators have used remote data entry systems in clinical trials. Many staff members have expertise in neuropsychological measures currently in use in Alzheimer's clinical trials including the CIBIC, ADAS, and NPI.

For more information, please contact:

David Ira Margolin, M.D., Ph.D.
1515 East Alluvial Ave, Suite 101
Fresno, CA 93720
Phone: 559-299-1515
Fax: 559-324-1941
Email: dimmd@sbcglobal.net

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