LGBT Cancer Project

Clinical Physiology Associates

Therapeutic Areas

Dermatology
Devices
Endocrinology
Family Medicine
Gastroenterology
Healthy Volunteers
Infections and Infectious Diseases
Internal Medicine
Neurology
Nutrition and Weight Loss
Obstetrics/Gynecology (Women’s Health)
Oncology
Rheumatology
Sleep
Urology
Vaccines

Center Overview

Clinical Physiology Associates, a multispecialty research group, has been conducting clinical trials for the pharmaceutical and medical device industries for 35+ years. The use of central IRBs and laboratories are preferred. Turn around time for regulatory documents is less than 3 days. 

Performance Metrics

Number of Studies Conducted: 626
Regulatory Submission Turn-Around Time: 3 Business Day(s)
Average Percent of ‘Completed’ Studies that met Enrollment Goals: 85%
EDC Capabilities: Yes

Clinical Research Experience

CPA Studies by discipline

Numbers within ( ) refer to the number of different medicines studied. Some medicines were studied in more than one protocol

Cardiology
  • Angina pectoris, chronic stable (30)
  • Congestive heart failure (9)
  • Hypertension (41)
  • Peripheral vascular disease (7)
  • Ventricular arrhythmias (4)
Central Nervous System
  • Alzheimer's disease (9)
  • Migraine headaches (5)
  • Seizure prophylaxis (4)
  • Stroke (ischemic) (1)
  • Tension headaches (1)
Dermatology
  • Psoriasis (1)
  • Tinea Cruris (1)
  • Tinea Pedis (1)
Endocrinology
  • Diabetes mellitus (7)
  • Diabetic neuropathy (15)
  • Obesity (2)
Gastroenterology
  • Acid Indigestion (1)
  • Constipation - opiate induced (1)
  • Gastroesophageal Reflux (chronic) (1)
  • Heart burn (1)
  • Irritable bowel syndrome – diarrhea predominant (4)
  • Irritable bowel syndrome – constipation predominant (1)
Genitourinary
  • Acute Urinary Retention (1)
  • Benign prostatic hyperplasia (11)
  • Bladder Cancer (superficial) (1)
  • Genital Herpes (3)
  • Hypogonadism [male] (1)
  • Impotence [erectile dysfunction] (15)
  • Impotence [erectile dysfunction] in spinal cord injury (1)
  • Impotence + dyslipidemia (1)
  • Nocturia (1)
  • Premature (rapid) ejaculation (1)
  • Premature (rapid) ejaculation + erectile dysfunction (1)
  • Prostate cancer (6)
  • Prostate Cancer Prevention (1)
  • Prostatitis (chronic) (2)
  • Sexual dysfunction (female) (6)
  • Sexual dysfunction (male & female) (1)
  • Urinary incontinence [urge, stress, mixed] (14)
  • Urinary tract infection [complicated, uncomplicated] (5)
Geriatrics
  • Chronic obstructive pulmonary disease (5)
  • Congestive heart failure (9)
  • Herpes zoster [shingles] (2)
  • Insomnia [elderly] (4)
  • Postherpetic neuralgia (9)
Gynecology
  • Contraception (2)
  • Osteopenia (1)
  • Osteoporosis (postmenopausal) (5)
  • Postmenopausal hormone replacement therapy (17)
  • Postmenopausal hormone substitute replacement therapy (1)
  • Premenstrual Dysphoric Disorder (PMDD) (2)
  • Premenstrual syndrome (PMS) (1)
  • Sexual dysfunction [women only] (6)
  • Sexual dysfunction [women & men] (1)
Internal medicine
  • Acid indigestion (1)
  • Angina pectoris (30)
  • Asthma (5)
  • Bronchitis (4)
  • Chronic obstructive pulmonary disease [COPD] (5)
  • Congestive heart failure [CHF] (9)
  • Constipation- opiate induced (2)
  • Diabetes mellitus (7)
  • Diabetic neuropathy (15)
  • Internal medicine, contd.
  • Diabetic neuropathic ulcers (2)
  • Gastroesophageal reflux (1)
  • Genital herpes (3)
  • Heartburn (1)
  • Hemorrhoids (1)
  • Herpes labialis (cold sores) (4)
  • Herpes zoster (shingles) (2)
  • Hypercholesterolemia (2)
  • Hypertension (41)
  • Hypertension + Osteoarthritis (1)
  • Infectious diseases [miscellaneous] (22)
  • Insomnia (2)
  • Insomnia [elderly] (4)
  • Irritable bowel syndrome (2)
  • Migraine headache (5)
  • Obesity (2)
  • Osteoarthritis (14)
  • Pain management (18)
  • Peripheral vascular disease (7)
  • Post- herpetic neuralgia (9)
  • Rheumatoid arthritis (1)
  • Sea sickness (1)
  • Skin & soft tissue infections (13)
  • Smoking cessation (1)
  • Tension headaches (1)
  • Urinary tract infections (5)
Miscellaneous
  • Sinusitis (2)
  • Venous Stasis Ulcers (2)
Neurology
  • Alzheimer's disease (9)
Oncology
  • Head & neck cancer (1)
  • Prostate cancer (8)
  • Prostate cancer prevention (1)
  • Prostatic intraepithelial neoplasia (PIN) (1)
  • Superficial bladder cancer (1)
Ophthalmology
  • Allergic conjunctivitis (1)
  • Bacterial Conjunctivitis (1)
  • Corneal Ulcer (1)
  • Ophthalmic Zoster (1)
Otolaryngology
  • Head & neck cancer (1)
  • Sinusitis (1)
Pharmacology
  • Hypogonadism (male) (1)
Surgery
  • Alzheimer's disease [neurosurgery] (1)
  • Decubitus ulcers [plastic & reconstructive surgery] (1)
  • Diabetic neuropathic ulcers [plastic & reconstructive surgery] (3)
  • Postoperative pain management [neurosurgery] (3)
  • Postoperative peridural fibrosis [neurosurgery] (2)
  • Scar revision [plastic & reconstructive surgery] (1)
  • Seizure prophylaxis [neurosurgery] (4)
  • Wound healing [plastic & reconstructive surgery] (2)

Pharmaceutical Companies worked with:

  • 3M Pharmaceuticals
  • A.H. Robins Company
  • Abbott Laboratories
  • Advanced Care Products
  • Aeterna
  • Alizyme Therapeutics, Ltd.
  • Allergan Pharmaceuticals
  • Alpha Therapeutic Corporation
  • Astellas
  • Astra Pharmaceuticals
  • AstraZeneca
  • Aventis
  • Barr
  • Bayer
  • Bayer Health Care
  • Berlex
  • Biosante
  • Boehringer Ingelheim Pharmaceuticals
  • Boehringer Mannheim Corporation
  • Bristol Myers Squibb Company
  • Burroughs Wellcome Company
  • Cellegy
  • Ciba Geigy Pharmaceutical Corporation
  • ConvaTec
  • Corcept
  • DepoMed
  • DuPont Pharmaceuticals
  • Duramed
  • Eisai
  • Eli Lilly and Company
  • Endo
  • Ethical Pharmaceuticals, Ltd.
  • Eunoe
  • Forest Research
  • FzioMed
  • Galen
  • G.D. Searle and Company
  • GlaxoSmithKline
  • Glaxo Welcome
  • Grunenthal
  • GTx, Inc.
  • Hisamitsu
  • Hoechst Roussel Pharmaceuticals
  • Hoffman LaRoche, Inc.
  • Human Geonome Science
  • IASO Pharma
  • ICI Pharmaceuticals
  • Indivus
  • International Medical Innovations
  • Interneuron Pharmaceuticals
  • Janssen Research Foundation
  • Johnson & Johnson
  • Key Pharm. Div. Schering Corp.
  • Kissei
  • Knoll
  • Labopharm
  • Lemmon Company
  • Lidak
  • Lilly
  • Lorex Pharmaceuticals
  • Lupin Ltd.
  • MacroChem
  • Magainin Pharmaceuticals, Inc.
  • Marion Merrell Dow Laboratories
  • Matrix
  • McNeil Consumer Products
  • McNeil Pharmaceutical
  • Merck
  • Miles Pharmaceuticals
  • Myriad
  • Neurobiological Technologies
  • Neurocrine Biosciences
  • NexMed
  • Nix-O-Tine Pharmaceuticals
  • NicOx SA
  • Novartis
  • Ono
  • Organon
  • Ortho- McNeil
  • Palatin Technologies
  • Parke-Davis
  • Pfizer (Groton)
  • Pfizer (New York)
  • Pharmacia
  • Pharmacia & Upjohn
  • Procter & Gamble
  • ProCyte Corporation
  • Radius Health
  • Reckett and Coleman
  • Reed and Carnrick
  • Revlon Health Care Group
  • Rhone Poulenc Rorer Pharmaceuticals
  • Roberts Pharmaceutical Corporation
  • Roche Bioscience
  • Roche Global Development
  • R.W. Johnson Pharm. Research Institute
  • Salix
  • Sandoz Pharmaceuticals
  • Sangamo
  • Sankyo U.S.A. Corp.
  • Sanofi Synthelabo
  • Schering Corporation
  • Schering Plough Research Institute
  • Schwarz Bioscience
  • Schwarz Pharma
  • Searle
  • Senju
  • Serono Laboratories, Inc.
  • SmithKline and French Laboratories
  • SmithKline Beecham Pharmaceuticals
  • Solvay
  • Sterling Winthrop
  • Stuart Pharmaceuticals
  • Sucampo
  • Sugen
  • Syntex Laboratories
  • Takeda America
  • Takeda Global
  • TAP Holdings
  • Tioga
  • Toyama
  • UCB Pharma
  • Unimed
  • Unither
  • Upjohn Company
  • Upsher Smith
  • USV Pharmaceutical Company
  • Vivus
  • W.F. Merchant Pharmaceutical Corporation
  • Wallace Laboratories
  • Wyeth Ayerst Laboratories
  • Wyeth Research
  • Xanodyne
  • XenoPort
  • Yamanouchi
  • Zeneca

Contract Research Organizations Worked With: 1978-Present

  • Barton & Polanski
  • Besselaar Associates
  • BioCLin
  • BioDecision Laboratories
  • BioPharm Clinical Services
  • Clinical Research Consultants
  • Clinical Research Group
  • Clinical Research Institute
  • Clinimetrics
  • Clinical Trial Management Services, Inc.
  • ClinTrials
  • Constella
  • Coromed
  • Covalent Research Alliance
  • Covance
  • Drug Research and Analysis Corporation
  • Health Decisions
  • i3 Research
  • IBRD
  • ICON Clinical Research
  • INC Research
  • Ingenix
  • Institute of Clinical Pharmacology
  • MDA Pharma
  • MDS Pharma Services
  • Medex
  • Medical and Technical Research Associates
  • Metropolitan Research Associates
  • Minnesota Clinical Study Center
  • Omnicare
  • Oxford Research International
  • PACT
  • Paragon Biomedical
  • Parexel
  • Pharmaco
  • Pharmaceutical Product Development
  • Pharmaceutical Resource Corp.
  • PharmaKinetics Laboratories, Inc.
  • PharmaNet
  • Phoenix International
  • PPD Development
  • PPD Pharmaco
  • Quintiles
  • Radiant Development
  • Resource Solutions
  • Scirex

Facility Description

  • Examination rooms (3)
  • Laboratory work areas (1)
  • Conference rooms [monitor work areas] (3)
  • Double locked limited accesstemperature controlled drug storage room with
    • Shelves
    • Counter tops
    • Refrigerator/ freezer
    • Steel locked controlled substance cabinet
  • Physician dictation area with X-ray view box
  • Video surveillance cameras with remote access
  • Coordinators’ offices (3)
  • Administrative offices (3)
  • Spacious waiting room
  • Rest rooms (2)
SPECIALIZED SCIENTIFIC EQUIPMENT

Urology

  • Dantec Urodyn 1000 urine flowmeter (2)
  • Diagnostics Ultrasound Bladder Scan (2)
  • Rigiscan Plus (with computer interface)
  • Infusion Equipment (IMED Gemini PC-1) (2)

Cardiovascular

  • Parks Penilab V (non- invasive vascular lab)
  • Parks hand-held transcutaneous Doppler flowmeter
  • Parks photoplethysmograph and miscellaneous instruments to perform non-invasive assessments of the peripheral and penile circulations
  • Hokanson automatic cuff inflator
  • Nihon Kohden Cardiofax V [12 lead EKG] (2)
  • Novametrix transcutaneous oxygen monitor (2 channel)
  • Omron digital blood pressure monitor (3)
  • Quinton Exerdop™

Anthropometry

  • Harpenden Stadiometer

Gynecology

  • Vabra endometrial biopsy aspirator & related instruments

Pulmonary

  • KoKo Spirometer with computer interface

Laboratory (dry ice is available daily)

  • Refrigerator/ freezer -20 degrees Celsius (various)
  • Clinical centrifuges
  • Refrigerated centrifuge (Jouan CR412)
  • Test tube shaker
  • Leitz binocular optical microscope
  • Temp-Blok module heater
  • Corning Biotrack 516

Computers & Related Items

  • High Speed Internet and fax
  • intra- office network
  • Computers
  • Demographics of the area (July 2009 University of Florida BEBR)

    • Population estimate: 625,124
      • Persons 65+ years of age: 150,029
      • Females 18+ years of age: 255,050
    • Study Center Database: 5071
      • # female patients 3,551
      • # male patients 1,520
      • # of persons 65+ years of age: 2,136
      • # of male patients 65+ years of age: 746
      • # of female patients +65 years of age: 1,390

Investigator Experience

Ronica Kluge, MD.
Board Certified Internal Medicine & Infectious Diseases

Kevin M. Fleishman, MD.
Board Certified Obstetrics and Gynecology

Adam Heller, MD.
Board Certified Psychiatry & Neurology

Stephen Zellner, M.D.
Board Certified Internal Medicine & Infectious Diseases

Staff Expertise

The study center is staffed with full time study coordinators, coordinators’ assistants and administrative personnel. All coordinators and their assistants are trained in shipping infectious & biological substances as per 49 CFR section 172,702 & IATA regulations. All staff members are trained in basic life support (CPR), HIPAA guidelines for clinical researchers and the protection of human research subjects.

Other Information

Institutional Review Boards Utilized

  • Chesapeake Research Review, Inc.
  • Coast Institutional Review Board
  • Copernicus Group
  • Essex Institutional Review Board
  • Independent Investigational Review Board, Inc.
  • Integ Review Ethical Review Board
  • Institutional Review Board for Clinical Physiology Associates (disbanded 1993)
  • Lee Memorial Health System Institutional Review Committee
  • New England Institutional Review Board
  • Quorum Review
  • RCRC Institutional Review Board
  • Research Consultants Review Committee Institutional Review Board (RCRC IRB)
  • Schulman Associates Institutional Review Board
  • St. Davids Human Research Review Board
  • Sterling Institutional Review Board
  • Western Institutional Review Board

Contact Center

If you are interested in contacting this center to discuss placing a clinical trial there, please complete and send the email form below. A representative from the research center will then follow up with you.