Trial information
Effect of NT-proBNP guided treatment of Chronic Heart Failure (PRIMA Study).
Status: No longer recruiting
Protocol number: 2003 B131
Company division: Diagnostic
Official Scientific Title: Can pro-brain natriuretic peptide guided therapy of chronic heart failure improve heart failure morbidity and mortality?
Brief summary: This study will determine whether NT-proBNP guided treatment of chronic congestive heart failure to an individually pre-defined target value will reduce heart failure-related morbidity and mortality compared to therapy guided by standard clinical judgement.
Study type: Interventional; Randomized; Open Label; Parallel study
Condition: Congestive Heart Failure
Intervention type: Diagnostic Test
Intervention name: ELECSYS®proBNP
Inclusion criteria:
- adult patients, ≥18 years of age;
- hospital admission for congestive heart failure;
- elevated NT-proBNP levels on admission.
Exclusion criteria:
- life-threatening cardiac arrhythmias;
- severe lung disease;
- patients undergoing hemodialysis or CAPD;
- urgent intervention;
- presence of life-threatening disease.
Gender: Males or Females
Age limits: Min: 18 Years Max: N/A (No limit)
Accepts healthy volunteers: No
Anticipated start date: May, 2004
Trial registration date: 08/22/2007
Date last updated: 11/21/2008
Link to trial result
This trial was conducted at the following locations:
Netherlands
- Amsterdam
- Delft
- Maastricht
- Rotterdam
- Utrecht
- Venlo
