Trial Information

Summary: To Determine the Effect of Vitamin D and Calcium on Genes in the colon (PHO 0554)

We are involved in a research program to understand how vitamin D and calcium in the diet or as supplements may lower the risk of colorectal polyps and cancer. To that end, we are conducting a study of vitamin D supplementation in which volunteer subjects are provided a Western style diet for 2 separate 4 week periods at the Rockefeller University Hospital. During one of these 4 week in patient periods they receive calcium supplement and during the other 4 week inpatient period they receive a placebo tablet. We determine changes within the colon as a result of supplementing the vitamin D in the presents of high and low calcium. A more detailed description of the study is provided below.

Patient Inclusion Criteria:

• Healthy Men and Women ages 48-72
• You have a history of colorectal adenomatous polyps
• And /or you have a family history of colorectal adenomatous polyps or colon cancer

Patient Exclusion Criteria:

• Personal history of cancer other than non-melanoma skin cancer
• Intestinal malapsorption or inflammatory bowel disease
• Any excessive bleeding or coagulation disorder or subjects taking anticoagulants
• Prior gastrointestinal surgery
• History of renal stones

For more information,

If you would like to learn more about participating in this study, please send an e-mail message using the form below.