Trial Information

Summary: Sensitivity to Fructose-Induced Palmitate Synthesis in End-Stage Renal Disease

This study will evaluate how a common dietary sugar (fructose) raises blood fats (triglycerides). We will determine whether the production of fat from fructose is higher in dialysis patients compared to healthy volunteers. Dialysis patients have high levels of hormone-like substances called cytokines that may increase blood fats. The results will help set better guidelines for diets for the general population and patients with kidney disease who are at high risk for heart attack and stroke.

If you join this study, you will have:

• One or two outpatient screening visit(s)
• A one-week (7 nights) stay at the Rockefeller University Hospital.

Patient Inclusion Criteria:

• Men and women
• At least age 18
• Hemodialysis three times a week for at least 3 months and meet the criteria for home instruction in nocturnal dialysis

• Diabetes
• Any unstable clinical condition, chronic infection (including hepatitis, HIV), endocrine disorders or serious digestive problems
• Lipid-lowering medication , LDL cholesterol >190 mg/dL and triglycerides greater than 600 mg/dL,
• BMI (Body Mass Index) greater than 35
• Blood pressure >180/110, hemoglobin >10.0
• Able to change from Renagel (has lipid effects) to Phoslo for the duration of the study,
• Cigarette smoking of more than half a pack per day

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Trial listings updated: June 1, 2008 at 5:45:22 AM