Trial Information

Summary: Study of transplantation using umbilical cord and placental blood

This study investigates the concept that umbilical cord blood stem cells can be used for allogeneic transplant with the same or better outcome as following a conventional bone marrow transplant.

Patients must fulfill the following criteria:

• Firm diagnosis by standard clinical and/or pathological criteria of chronic myeloid leukemia, acute leukemia, lymphoma, myeloma, myelodysplasia, aplastic anemia, Fanocni's anemia, histiocytosis, hereditary immunodeficiency, and storage disorders
• Physiological age < 60 years
• Non pregnant, non lactating
• No other serious medical or psychiatric illness preventing informed consent or intensive treatment (e.g., serious infection)
• Consensus agreement that UCB transplantation is appropriate after discussion at Adult Leukemia/Lymphoma/Hematology conference, Pediatric Oncology Rounds, Medical Oncology BMT Conference or Pediatric Hematology Rounds
• Eligible for standard allogeneic BMT but lacking a suitable marrow or blood stem cell donor.
• Availability of UCB form the NY Blood Center which is mismatched for 0, 1, or 2 HLA loci, Serological tissue typing for class I antigens and serological methods or low resolution DNA testing for class II antigens.
• Availablity of UCB which contains more than or equal to 1x 10⁷ nucleated cells/kg ideal body weight of recipient and which is seronegative for HIV, hepatitis B₅ Ag. and hepatitis C virus.
• Serum bilirubin < 2x normal and no other evidence of severe hepatic disease
• Recipient seronegative for HIV, hepatitis B₅ Ag. and hepatitis C virus.

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Trial listings updated: June 1, 2008 at 5:43:10 AM