Trial Information

Summary: PHI-47 NCI#6581: Phase I Trial of R115777 (NSC 702818) In Relapsed, Refractory or High-Risk Myeloid Leukemia

You have been asked to participate in this research study because you have acute myeloid leukemia (AML) that has relapsed (returned after initially responding to chemotherapy) or is refractory (has failed to respond to standard therapy) or you have a high risk myeloid malignancy that would not be effectively treated by standard chemotherapy. The purpose of this study is to determine the highest dose of the investigational drug R115777 (Zarnestra(tm)) that can be given to treat acute myeloid leukemia without causing unmanageable side effects. Another purpose is to do an early evaluation of side effects and possible effects on disease. Your participation in this study is expected to last at least four weeks (one cycle of treatment). If you are tolerating treatment and your medical condition is not getting worse, you will be able to receive additional cycles of treatment. It is anticipated that most subjects will receive this drug for about three months. After you discontinue treatment, your medical condition will continue to be followed indefinitely.

Patient Inclusion/Exclusion Criteria:

- See http://clinicaltrials.coh.org for additional information.

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Trial listings updated: June 2, 2008 at 2:50:51 PM