Trial Information

Summary: Clinical study for Schizophrenia

According to the National Institute of Mental Health, one out of every 100 adults suffers from schizophrenia, a serious brain disorder. More than two million Americans suffer from schizophrenia, with symptoms such as hallucinations, delusions, disordered thinking, social isolation/withdrawal, and depressive symptoms such as flat mood.

A nationwide clinical study is seeking volunteers diagnosed with schizophrenia. Participation in the study involves 28 outpatient visits over two years, including visits every 6 months to an ophthalmologist, and includes FDA-approved investigational study medication and study-related examinations and health assessments.

Inclusion Criteria
Volunteers must:

• Be age 18-65, male or female
• Have a clinical diagnosis of schizophrenia, as confirmed by DSM-IV criteria
• Be clinically stable enough to be treated in an outpatient setting and able to cooperate with eye examinations every six months
• Be of stable residency for at least three months prior
• Have both eyes and their respective lenses intact
• If treated with mood stabilizers or antidepressants for other psychiatric symptoms or disorders, been on stable dosage for at least one month prior to study entry

Exclusion Criteria
Volunteers must not:

• Be pregnant, or planning a pregnancy
• Be diagnosed with any DSM-IV Axis I disorder other than schizophrenia
• Have a history of narrow-angle glaucoma, cataract extractions/lens absence, corneal surgery, or significant eye trauma
• Be legally blind or have significant eye disease requiring treatment
• Have been treated for eye injury or eye disease within the previous 30 days
• Exhibit current evidence of advanced cancer, HIV, and/or liver, renal or heat disease

Other criteria may apply. For a complete list of study centers, or for more information,

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Trial listings updated: June 1, 2008 at 5:44:37 AM