Trial Information

Summary: Are you down in the dumps with your diabetes?

Recent studies suggest that depression may be associated with insulin resistance, and this insulin resistance can be reversed with successful depression treatment. Washington University School of Medicine is conducting a research study that will offer treatment to patients with major depressive disorder and type 2 diabetes, with it is designed to determine whether depression improvement during bupropion treatment is associated with improvement in glycemic control.

Bupropion has pronounced antidepressant effects, along with the potential benefit of weight loss, and a side effect profile that favors its use in diabetes (e.g., fewer sexual side effects)

The overall purpose of this study is designed to determine whether depression improvement during bupropion treatment is associated with improvement in glycemic control. Bupropion has pronounced antidepressant effects along with the potential benefit of weight loss and a side effect profile that favors its use in diabetes (e.g., fewer sexual side effects).

The study will be an open-label trial with individual subject participation lasting a maximum of 9 months (8-12 weeks acute phase treatment plus 6 months maintenance therapy).

Measured treatment effects will include mood, glycemic control, weight, activity level, and quality of life management.

Inclusion Criteria: Ages 18-80, obesity, non-insulin-dependent diabetes and with symptomatic major depression; minorities encouraged to apply.

Exclusion Criteria: Bi-polar depression, schizophrenia, diagnosed Type 2, advanced kidney or heart disease; those who have any active suicidal ideation or a history of attempted suicide.

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Trial listings updated: June 1, 2008 at 5:43:45 AM