Trial Information

Summary: A Placebo-Controlled Study of Metformin Effectiveness in Counteracting Insulin Resistance and Weight Gain in Patients Treated with Clozapine and Olanzapine.

This research study is examining the effects of a medication called metformin (Glucophage) on weight gain associated with the antipsychotic medications clozapine (Clozaril) and olanzapine(Zyprexa). The aim of this study is to investigate if adding metformin to participants current medication regimen can stop them from gaining weight, or even allow them to lose weight.

This is a 12 month study. If eligible to participate in this research study, participants will receive research study medication and treatment at no charge. Transportation reimbursement will also be provided at the request of the participant.

For a detailed description of this study or to schedule an appointment please contact the study coordinator, Carine Jean-Louis at (212) 659-8795
No Compensation Provided

Patient Inclusion/Exclusion Criteria:

This research study is open to individuals between the ages of 18-55 years old that are taking the antipsychotic medication clozapine (Clozaril) or olanzapine (Zyprexa)and have gained weight because of these medications but are otherwise in good health.

Females who are pregnant or nursing and individuals with a serious or unstable medical condition will not be eligible to participate in this research study.

If you would like to learn more about participating in this study, please send an e-mail message using the form below.