Trial Information

Summary: Study investigating how well antidepressant response is maintained over periods of one year in patients with major depression

This study which has been funded by the National Institute of Mental Health, includes people with major depression and investigates how well antidepressant response is maintained over periods of one year. All participants will receive treatment with Prozac (fluoxetine) for 12 weeks on an open-label basis, i.e. without anyone receiving placebo. Individuals who respond well to this treatment will be randomly assigned to either continue it for a follow-up period of one year or switch to placebo, under double-blind conditions. Any relapse of depression during the follow-up period will be treated with appropriate antidepressant medication. Nonresponders to Prozac will receive alternate medication. A minimum of six months treatment is provided for all participants. All treatment and medication during the study is provided at no cost.

Eligible participants must be in generally good physical health, must not have had any previous manic episode or psychosis, and must be free of alcohol and drug abuse for six months prior to entering the study.

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Trial listings updated: June 1, 2008 at 5:43:16 AM