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Therapeutic Areas: Psychiatry/Psychology
Disease Category: Depression
Trial Information
Dichotic Listening as a Predictor of Medication Response in Depression
Individuals will receive bupropion (Wellbutrin), and if they do not respond, escitalopram (Lexapro), and if they do not respond to either, imipramine (Tofranil). They will complete dichotic testing, which consists of cognitive tasks designed to measure heightened right or left hemispheric perceptual processing, which we believe may be able to predict which individuals will respond positively to antidepressants.
Patient Inclusion Criteria
- Age 18 to 65 years (ages 23 to 50 for MRI sub-study)
- Diagnosis of major depression, dysthymic disorder (chronic depression) or depression NOS
Patient Exclusion Criteria
- Known hearing impairment
- Diagnoses including delirium, dementia, bipolar disorder I, schizophrenia
- Substance abuse or dependence in the past 6 months
- Pregnant or nursing women
- Active suicide risk
Sarah Black, Study Coordinator
New York State Psychiatric Institute
Depression Evaluation Services (DES)
1051 Riverside Dr., #51
New York NY 10032
Phone: 212-543-5767
EMail: blacksa@pi.cpmc.columbia.edu
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