Trial Information

Summary: A Double Blind, Placebo Controlled Trial of Quetiapine in Anorexia Nervosa, a Dual Site Study

USF Dept of Psychiatry is recruiting men and women with Anorexia Nervosa for a Double-Blind Research Study. Subjects must be 18 to 65 yrs old and at least 15% below ideal body weight. Must be fearful of gaining weight, even though underweight and able to keep 8 clinic appointments. Research studies raise the possibility that medications such as quetiapine may improve mood or reduce obsessions in people with anorexia nervosa and may even help to normalize appetite.

Brief Summary:
Research studies raise the possibility that medications such as quetiapine may improve mood or reduce obsessions in people with anorexia nervosa and may even help to normalize appetite. The medication quetiapine also known as seroquel works by activating certain systems in the brain, such as ones known as dopamine and serotonin chemical systems in the brain.

Eligibility Criteria:

• Must be aged 18-65
• Must be at least 15% below ideal body weight
• Gender:Females and Males

Exclusion Criteria:

• Allergy to quetiapine
• Diagnosis of schizophrenia
• Accepts Healthy Volunteers? No

Outcome Measures: To determine efficacy of seroquel in anorexia nervosa

Time Frame: 8 weeks

Safety Issue?: No

Interventions: Drug: quetiapine quetiapine dosage will be titrated to subject tolerance beginning at 50 mg every 24 hours upwards to 400 mg every 24 hours.

KeySecondary Outcomes:Time Frame: 8 weeks

Safety Issue?: No

Interventions: Drug: quetiapine quetiapine dosage will be titrated to subject tolerance beginning at 50 mg every 24 hours upwards to 400 mg every 24 hours.

http://www.hsc.usf.edu/PSYCH/index.html

If you would like to learn more about participating in this study, please send an e-mail message using the form below.