Trial Information

Summary: Cardiovascular and Renal Hemodynamics and the DASH Diet

Brigham and Women’s Hospital Divisions of Endocrinology and Cardiovascular Medicine are enrolling adult volunteers to participate in a research study investigating how the DASH diet affects blood pressure and the heart’s function. The study requires a medical evaluation, eating a fixed diet for 9 weeks and 2 separate 1-day overnight hospital stays.

Eligibility Criteria:
Age: 20 years and older
Major inclusion criterion
Isolated systolic hypertension: systolic blood pressure (SBP) measured between 140-179 mmHg and diastolic blood pressure (DBP) < 90 mmHg.

Other inclusion criteria
Body mass index (BMI) less than 40
Current use of less than 2 blood pressure medications (which will be withdrawn prior to study)
No major concomitant diseases, which may include but are not limited to: no active pulmonary disease within the past 6 months; no history of cardiovascular disorders, such as angina, heart attack, heart failure or stent placement; no active gastrointestinal disease, including no prior gastrointestinal surgery; renal disease with serum creatinine > 1.5 mg/dl (men) or 1.4 mg/dl (women); insulin dependent diabetes mellitus; current pregnancy.

If you would like to learn more about participating in this study, please send an e-mail message using the form below.