Trial Information

Summary: Severe Migraine Headaches- Adults

People with severe migraine attacks are asked to participate in a research study being conducted by Montefiore Medical Center.

You may be eligible to participate in this study if you:

• Are between the ages of 18 and 65
• Have a history of migraines for at least 1 year without aura
• Experience an average of at least 4 migraine attacks per month over a 3 month period

You may not participate in this study if you:

• Are taking other medications used as prophylaxis for migraine including topiramate, methysergide, anti-spasticity agents (e.g. tizanadine) and new generation antipsychotics (e.g. olanzapine) currently or within 1 month
• Are taking any of the following medications: beta-blockers (such as atenolol and metoprolol), tricyclic antidepressants (such as imipramine, amitriptyline, and doxepin), antiepileptic drugs (such as Gabapentin, Lamotrigine, Felbamate, Topiramate and Fosphenytoin), calcium channel blockers (such as Norvasc or Cardizem, or monoamine oxidase inhibitors during or within 1 month (such as Nardil or Marplan), daily oral NSAIDs (such as ibuprofen), daily paracetamol, high dose magnesium supplements (600 mg/day), daily multivitamin preparations containing more than 10 mg riboflavin, daily use of oral corticosteroids (such as prednisone), herbal preparations (e.g. feverfew, butterwort and St John’s Wort), or have received parenteral administration of botulinum toxin (Botox) within the previous 3 months
• Have cerebrovascular or cardiovascular disease
• Suffer from any significant psychiatric disorder (e.g. schizophrenia, major depressive disorder, bipolar disorder).
• Have renal or hepatic (liver) dysfunction
• Are an alcohol or other substance abuser
• Are pregnant, breastfeeding, or intend to become pregnant during the study
• Have participated in another research study within the last 30 days

If you would like to learn more about participating in this study, please send an e-mail message using the form below.