Trial Information

Summary: Role of Goandotropin Pulsations in the Reversal of Hypogonadotropic Hypogonadism

The purpose of the research study is to examine how Kallmann syndrome (KS) and idiopathic hyopgoandotropic hypogoandism (IHH) affect reproductive hormones. These disorders are caused by a defect in Gonadotropin Releasing Hormone (GnRH) secretion. GnRH is a hormone released by a small gland in the brain called the hypothalamus. When GnRH is released, it signals another gland in the brain, the pituitary to secrete the reproductive hormones that influence testosterone levels and reproductive function.

This study involves a detailed evaluation which involves an overnight study at the hospital. Some adult men may continue on to receive treatement with pulsatile GnRH to replace the absent hormone to stimulate normal testosterone levels and fertility.


Eligibility Criteria:
Adult men and women 18+ yrs
Adolescent boys 16+ yrs

Individuals with IHH and KS:
1) have abnormally low hormone levels
2) may have not gone through a normal puberty
3) often have infertility

If you would like to learn more about participating in this study, please send an e-mail message using the form below.