NIH Studies: Immunology/Infectious Diseases

Below is a listing of government-funded clinical trials in Immunology/Infectious Diseases, being conducted by the various National Institutes of Health at the Warren Grant Magnuson Clinical Center in Bethesda, MD.

Click on a study summary to view the study description and contact information directly from the NIH's web site.

Evaluation and Treatment of Persons with Serious Complications Associated with Vaccinia Vaccination

Phase 1 Study of the Safety of Immunization of Naive Individuals with AMA1-C1/Alhydrogel, an Asexual Blood-Stage Vaccine for Plasmodium Falciparum Malaria, and the Effect of Immunization on Antigen-specific Memory and Plasma B Cells and T Cells

VRC 008: A Phase I Clinical Trial of a Prime-Boost HIV-1 Vaccination Schedule: Multiclade DNA Vaccine, VRC-HIVDNA016-00-VP, Followed by Multiclade Adenoviral Vector Vaccine, VRC-HIVADV014-00-VP, in Uninfected Adult Volunteers

Immune Responses to Vaccinia Virus Vaccination

Clinical and Immunological Evaluation of Children with Allergic Disease

A Phase I Clinical Trial to Evaluate the Safety and Immunogenicity of a Booster Dose of a Recombinant Multiclade HIV-1 Adenoviral Vector Vaccine, VRC-HIVADV014-00-VP, in Uninfected Subjects Who Were Previously Immunized with VRC-HIVDNA009-00-VP in VR...

A Double-Blind, Randomized, Placebo-Controlled Study to Evaluate the Effect of Leflunomide on HIV-1 Associated Immune Proliferation In Vivo

A Phase I Clinical Trial to Evaluate the Safety and Immunogenicity of a Booster Dose of a Recombinant Multiclade HIV-1 Adenoviral Vector Vaccine, VRC-HIVADV014-00-VP, in Uninfected Subjects Who Where Previously Immunized with VRC-HIVDNA016-00-VP in V...

A Randomized Controlled Trial to Evaluate the Safety and Efficacy of Twice-Weekly Peginterferon Alpha 2a and Ribavirin Induction Therapy for Chronic Hepatitis C in Patients who are Coinfected with HIV-1

Genetic Studies of the X-Linked Lymphoproliferative Disease

Identification of Novel Viruses

To Develop a New Technique to Predict the Occurrence of Pneumocystis Pneumonia, Track its Epidemiology, Diagnose Acute Disease, and Predict and Monitor the Response to Various Therapeutic Agents

An Omnibus Proleukin (IL-2) Trial in HIV-Infected Patients Including Interrupted Versus Continuous Antiretrovirals (OPTICA): A Substudy of Interrupted Versus Continuous Antiretrovirals Involving Randomization From the Umbrella Study (ICARUS)

A Phase I Study of the Safety and Immunogenicity of a West Nile Virus Recombinant DNA Plasmid Vaccine, VRC-WNVDNA017-00 VP, in Healthy Adult Volunteers

Leukapheresis Procedures to Obtain Plasma and Lymphocytes for Research on HCV-Infected Patients

A Phase I Clinical Trial of Intramuscular, Subcutaneous and Intradermal Administration of an HIV-1 Multiclade DNA Vaccine, VRC-HIVDNA016-00-VP, and an HIV-1 Multiclade Adenoviral Vector Vaccine,VRC-HIVADV014-00-VP, in Uninfected Adult Volunteers

Infliximab Treatment for Crohn's-like Inflammatory Bowel Disease in Chronic Granulomatous Disease: A Phase I/II Study Assessing Clinical and Immune Responses to Treatment and Genetic Influences

Phase 1 Study of the Safety and Immunogenicity of PpPfs25/ISA51 and ScPvs25/ISA51: Transmission Blocking Vaccines for Plasmodium Falciparum and Plasmodium Vivax Malaria

A Phase I Double-Blind, Placebo-Controlled, Dose-Escalating Study to Evaluate the Safety and Tolerability of Intravenous Peramivir in Healthy Subjects

A Phase I Study of the Safety and Immunogenicity of a West Nile Virus Recombinant DNA Plasmid Vaccine, VRC-WNVDNA020-00-VP, in Healthy Adult Subjects

A Randomized, Open-Label, Phase II, International Study of Subcutaneous Recombinant Interleukin-2 (Proleukin) With and Without Concomitant Antiretroviral Therapy in Patients with HIV-1 Infection and CD4+ Cell Counts Greater Than or Equal to 300/mm(3)

Salmonella Typhi Vi O-Acetyl Pectin-rEPA Conjugate Vaccine

VRC101: A Phase I/II Clinical Trial to Evaluate the Safety and Immunogenicity of a Prime-Boost HIV-1 Vaccination Schedule of a 6-Plasmid Multiclade HIV-1 DNA Vaccine, VRC-HIVDNA016-00-VP, Followed by a Recombinant Multiclade Adenoviral Vector HIV Va...

Evaluation of Alternative Oseltamivir (Tamiflu) Dosing Strategies for Use During Influenza Prophylaxis

Epidemiology, Infectivity and Natural History of Hepatitis C Virus Infection in a Blood Donor Population

Study of Patients with Known or Suspected Infection with Strongyloides stercoralis

Host Response to Infection and Treatment in the Filarial Diseases of Humans

Treatment of Patients with Cysticercosis with Praziquantel or Albendazole

Study of Patients with Parasitic Infections of the Gastrointestinal Tract

Comparison of Inflammatory Responses in Normal Volunteers and Patients with Abnormal Phagocyte Function Using the Suction Blister Technique

Apheresis Procedures to Obtain Plasma or Lymphocytes for In Vitro Studies

Long-Term Therapy with Ribavirin for Chronic Hepatitis C

Evaluation and Long Term Follow Up of Patients with Acute or Chronic Inflammatory Disorders

Langerhans' Cell Function and Inflammatory Responses in Skin of Normal Volunteers and Patients with Helminth Infections Using the Suction Blister Technique

Immunogenetics of Hepatitis C Virus Infection

The Hep C Antiviral Long-Term Tx Against Cirrhosis (HALT-C) Trial: A Randomized Controlled Trial to Evaluate the Safety & Efficacy of Long-Term Peginterferon Alpha-2A for Tx of Chronic Hep C in Patients Who Failed to Respond to Previous Interferon T...

An Assessment of the Relationship Between Antiretroviral Drug Genotype/Phenotype (IC50) and Antiretroviral Activity in HIV-Infected, Drug-Experienced Patients with Suboptimal Suppression of Plasma Viral Load

High Dose Versus Standard-Dose Oseltamivir for the Treatment of Severe Influenza and Avian Influenza: A Phase II Double-Blind, Randomized Clinical Trial

The Immune Basis for the Gastrointestinal Complications of Common Variable Immunodeficiency

Immunologic and Virologic Characterization of HIV-Infected Patients After Cessation of Highly Active Antiretroviral Therapy (HAART)

Studies of Lymphocyte Kinetics Using Stable Isotopes

Screening and Natural History of Patients with Polyostotic Fibrous Dysplasia and the McCune-Albright Syndrome

Molecular Basis of Primary Immunodeficiencies

Genetic Analysis of Immune Disorders

Detection and Characterization of Host Defense Defects

Study of the Immunopathogenesis, Natural History, and Genetics of a New Autoimmune Lymphoproliferative Syndrome (ALPS) Associated with an Expansion of CD4-8-/TCRalpha/beta+ T Cells and Defective Lymphocyte Apoptosis

Studies of Immune Regulation in Patients with Common Variable Immunodeficiency and Related Humoral Immunodeficiency Syndromes

Studies of the Pathogenesis of HIV Infection in Human Peripheral Blood Cells

Role of Exotoxins in the Pathogenesis of Pseudomonas Aeruginosa

Analysis of Peripheral Blood Versus Lymphoid Tissue in HIV-Infected Individuals and Normal Patients

Polymorphism of the Herpes Simplex Virus Receptor

Evaluation, Treatment, and Monitoring of Patients with Known or Suspected Parasitic Infection

A Comprehensive Clinical, Microbiological and Immunological Assessment of Patients with Suspected Chronic Lyme Infection and Selected Control Populations

Virologic and Immunologic Evaluation of Lymph Node and Tonsillar Biopsies

Cryptococcosis in Previously Normal Adults

Treatment of Chronic Delta Hepatitis with Pegylated Interferon

Evaluation of Plasma Lipoproteins

Low Dose Peginterferon and Ribavirin Therapy for Patients with Chronic Hepatitis C Infected with Genotype 2 or 3

Collection of Blood, Stool, Bone Marrow and/or Tissue Samples from Subjects with Hepatitis-Associated Aplastic Anemia

Treatment of Chronic Graft Versus Host Disease with Extracorporeal Photopheresis

Screening HIV-Infected Subjects for Vaccine Research Studies

Determining the Pathogenesis of Systemic Pediatric-Onset Mastocytosis

Natural History of Anthrax: A Study of Primary Infected, Recovered, and Exposed (SPoRE) Individuals and Evaluation of AVA Vaccinated Recipients

Natural History, Genetics, Phenotype and Treatment of Mycobacterial Infection

Global Initiative to Characterize Differences in Antiretroviral Pharmacokinetics in HIV-Infected Populations

Clinical and Basic Investigations into Hermansky-Pudlak Syndrome

Evaluation of Potential Synergy of Combining Hydroxyurea with Nitric Oxide Donors on Fetal Hemoglobin Synthesis in Patients with Sickle Cell Anemia

Apheresis Procedures to Obtain Plasma or Peripheral Blood Mononuclear Cells for Research Studies

An Investigation of the Inflammatory Response in Severe Acute Respiratory Syndrome (SARS)

Screening of Healthy Volunteers for Clinical Trials of Investigational Vaccines to Prevent Infectious Diseases

A Pilot Study of Fluorodeoxyglucose Positron Emission Tomography (FDG-PET) for the Evaluation of the Autoimmune Lymphoproliferative Syndrome and ALPS-Associated Lymphoma

A Phase I/II Randomized, Placebo-Controlled Trial to Assess the Safety and Efficacy of Intravenous Immunoglobulin G (Omr-IgG-am) Containing High Anti-West Nile Virus Antibody Titers in Patients with, or at High Risk for Progression to West Nile Virus...

The Determination Of Genetic Basis Of Immunodeficiency

Genetic Studies of Chronic Active Epstein-Barr Virus Infection

Combination of Lamivudine and Adefovir Dipivoxil for Treatment of Chronic Hepatitis B

A Prospective Study of Transfusion-Transmitted Infections

Rituximab (Anti-CD20) for the Treatment of Hepatitis C Associated Cryoglobulinemic Vasculitis

Leukapheresis Procedures to Study HIV-Specific Immunity

Studies of Specific Immune Responses to HIV in Human Peripheral Blood Cells in HIV-Infected and HIV-Uninfected Volunteers

Ex Vivo Retroviral Transfer For Treatment of X-Linked Severe Combined Immunodeficiency

A Pilot Study of the Safety and Efficacy of Imatinib Mesylate in Reducing Eosinophilia in Patients with the Myeloproliferative Form of Hypereosinophilic Syndrome

Combination of Pegylated Interferon and Ribavirin as Therapy for Patients with Chronic Hepatitis C with and without Renal Disease

HIV Expression in Patients with Viral Loads Suppressed on HAART

Open Label Limited Access Protocol of Posaconazole in Invasive Fungal Infections

Leukapheresis Procedures to Obtain Plasma and Lymphocytes for Research Studies on Antiretroviral Naive HIV-Infected Individuals

Investigations into Chediak-Higashi Syndrome and Related Disorders

Clinical, Biochemical, and Molecular Investigations into Alkaptonuria

Therapeutic Clinical Trial of Oral Pirfenidone for the Pulmonary Fibrosis of Hermansky-Pudlak Syndrome

Investigation of the Natural History of West Nile Infection in Patients with, or at Risk for Progression to West Nile Virus Encephalitis and/or Myelitis

Evaluation, Treatment and Follow up of Patients with Lyme Disease

Genetic Disorders of Mucociliary Clearance

Correlation of the Precursor Frequency of CD4 + Effector Memory T Cells with Induration Measured in the Tuberculin Skin Test (TST)

Pilot Study of Omalizumab (Xolair) in Hyper IgE (Job's) Syndrome

Microarray Analysis of Erythema Migrans Lesions

A Pilot Study of Safety and Efficacy of the Oral IL-12/23 Inhibitor, STA-5326 Mesylate, for Symptomatic Gastrointestinal Inflammation Associated with Common Variable Immunodeficiency

Values at the Bedside: A Survey of European Physicians Regarding Ethical Dilemmas in Clinical Practice

Studies of Disorders in Antibody Production and Related Primary Immunodeficiency States

Collection of Blood from Persons with Hemoglobin and Erythrocyte Polymorphisms for Laboratory Malaria Research

Assessing the Relationship Between Fatigue and Mitochondrial Toxicity in Patients with HIV/AIDS

Evaluation of Risk Factors for Development of Epstein-Barr Virus Lymphoproliferative Disease

Screening and Baseline Assessment of Patients with Abnormalities of Immune Function

A Multi-Institutional, Phase II Clinical Trial of 17-(Allylamino)-17-Demethoxygeldanamycin (17-AAG, NSC 330507 and EPL Diluent, NSC 704057) in Adult Patients with Systemic Mastocytosis

Transplant-Related Accelerated Progression of Hepatitis C (TRAP-C)

A Randomized Placebo Controlled Trial of Atorvastatin in HIV Positive Patients Not on Antiretroviral Medications with the Specific Aims of Studying the Effects of Atorvatsatin on HIV Viral Load and Immune Activation Markers

Influence of MDR-1 CYP3A4 and CYP3A5 Genotypes/Haplotypes on Sirolimus Pharmacokinetics and Pharmacodynamics in Patients with Renal Transplantation

Collection of Blood From Volunteers and Patients for Studies of Endothelial Function and Systemic Inflammation

A Pilot Study of Hepatic Fibrosis in HIV/AIDS Patients with Chronically Elevated Transminases on Antiretroviral Therapy

Diagnosis and Treatment of Leishmanial Infections

The Evaluation of Focal Contrast-Enhancing Brain Lesions in HIV-Infected Patients

I.R.O.N (Iron Replacement or Not)

A Cohort Observational Study Evaluating the Incidence and Immunopathogenesis of Immune Reconstitution Syndrome (IRIS) in HIV-1 Infected Patients with CD4 Count less than or equal to 100 Cells/micro L who are Initiating Antiretroviral Therapy

Evaluation of Immune Response to Vaccines in Primary Immune Disorders

Voriconazole Plasma Concentration and Toxicity

Investigation of Southern Tick-Associated Rash Illness (STARI)

A Study of Central Nervous System Disease in Pediatric HIV in the HAART Era

Retrospective Review of Cardiomyopathy Patient Cases Post Allogeneic Hematopoietic Stem Cell Transplantation

Last updated: September 15, 2006 at 4:30:37 PM