NIH Studies: Oncology

Below is a listing of government-funded clinical trials in Oncology, being conducted by the various National Institutes of Health at the Warren Grant Magnuson Clinical Center in Bethesda, MD.

Click on a study summary to view the study description and contact information directly from the NIH's web site.

A Randomized Pilot Phase II Study of Docetaxel alone or in Combination with PANVAC-V (Vaccinia) and PANVAC-F (Fowlpox) in Patients with Metastatic Breast Cancer

A Biomarker and Phase II Study of GW 572016 in Recurrent Malignant Glioma

A Phase I Trial of Enzastaurin (LY317615) in Patients with Recurrent Gliomas

A Phase II Trial of Tamoxifen and Bortezomib in Patients with Recurrent High-Grade Gliomas

A Phase I Study of Image Guided Dose Escalation with Intensity Modulated Radiation Therapy (IMRT) to Histologically Confirmed Regions of Prostate Cancer

Morbidity Following the Diagnosis and Treatment of Patients with Breast Cancer: A Multi-Institutional Study Between NIH/RMD and NNMC Breast Care Center

Ethics Study to Understand the Views of Cancer Patients Regarding Financial Conflicts of Interest in Research

A Prospective (Cohort) Study to Identify Factors Affecting Morbidity Following the Diagnosis and Treatment of Patients with Breast Cancer: A Multi-Institutional Study Between NIH/RMD and NNMC/BCC

Phase II Evaluation of Peptide Immunization and LMB-2 in Metastatic Melanoma

Phase I/II Study of OSI-774 (Erlotinib) and CCI-779 (Temsirolimus) in Patients with Recurrent Malignant Glioma

Phase II Trial of Neoadjuvant Chemotherapy in Sporadic and Neurofibromatosis Type 1 Associated High Grade Malignant Peripheral Nerve Sheath Tumors

AIDS-related Primary Central Nervous System Lymphoma: A Phase II Pilot Study of High-Dose Intravenous Methotrexate with Rituximab Leucovorin Rescue and Highly Active Antiretroviral THerapy

(131)I-Metaiodobenzylguanidine Treatment of Malignant Pheochromocytoma

A Phase III, Randomized, Double-Blind, Placebo-Controlled Trial of Oral Suberoylanilide Hydroxamic Acid (L-001079038) in Patients with Advanced Malignant Pleural Mesothelioma Previously Treated with Systemic Chemotherapy

Prospective Evaluation of Epigenetic Alterations in Patients with Lung and Esophageal Cancers and Malignant Pleural Mesotheliomas

Phase II Trial of Ixabepilone (BMS-247550), an Epothilone B Analog, in Children and Young Adults with Refractory Solid Tumors

Treatment of Patients with Locally Advanced and Metastatic Pancreatic Adenocarcinoma with the Single Agent MDX-010 (anti-CTLA4)

Variation in Gene Expression in Neurofibromatosis Type 1

A Phase 2 Study of 17-Allylamino-17-Demethoxygeldanamycin in Patients with Von Hippel Lindau Disease and Renal Tumors

A Phase I Study of CC-5013 (Lenalidomide, NSC 703813, IND 70116) in Relapsed/Refractory Solid Tumors or Myelodysplastic Syndrome

A Randomized Study of the Effect of Tai Chi Chuan Compared to a Structured Exercise Program on Parameters of Physical Fitness and Stress in Adult Cancer Survivors

Studies on Thyroid Nodules and Thyroid Cancer

An Open Label Pilot Study to Evaluate the Safety and Tolerability of PANVAC-V (Vaccinia) and PANVAC-F (Fowlpox) in Combination with Sargramostim in Patients with Metastatic Adenocarcinoma

Low Intensity Preparative Regimen Followed by HLA-MAtched, Mobilized Peripheral Blood Stem Cell Transplantation for Systemic Mastocytosis

A Phase II Study of Oral CC-5013 Lenalidomide (Revlimid), an Antiangiogenic and Immunomodulatory Agent, in Patients with Stage IV Ocular Melanoma

The Effect of Lithium Carbonate on Low Dose Radioiodine Ablation in Early Thyroid Cancer Treatment

Evaluation of Whether the Selective Progesterone Receptor Modulator CDB-2914 Can Shrink Leiomyomata

Immunization of Patients with Renal Cancer Using HLA-A2 and HLA-A3-Binding Peptides from Fibroblast Growth Factors 5 (FGF-5)

A Phase II Study Using a Peptide Vaccine Following a Lymphodepleting Chemotherapy and Reinfusion of Autologous Lymphocytes Depleted of T Regulatory Lymphocytes in Metastatic Melanoma

Primary Effusion Lymphoma: A Pilot Trial Bevacizumab and Modified Dose-Adjusted Infusional CDE Chemotherapy Preceded by a Brief Pre-Phase Assessment of Targeted Oncolytic Virotherapy with Bortezomib, Zidovudine and Valganciclovir

A Phase I Study of the Effect of Mistletoe Extract, a Complementary, Medicine Botanical, on Pharmacokinetics, Pharmacodynamics and Safety of Gemcitabine in Patients with Advanced Solid Tumors

A Phase II Study to Evaluate the Efficacy, Safety, and Pharmacodynamics of Lapatinib in Patients with Relapsed or Refractory Inflammatory Breast Cancer

A Pilot Study of Image Guided Prostate and Pelvic Nodal Irradiation with Intensity Modulated Radiation Therapy (IMRT)

A Phase I/II Study of HLA-matched Mobilized Peripheral Blood Hematopoietic Stem Cell Transplantation for Advanced Mycosis Fungoides/Sezary Syndrome Using Nonmyeloablative Conditioning with Campath-1H

A Phase II trial of Docetaxel, Thalidomide, Prednisone and Bevacizumab in Patients with Androgen-Independent Prostate Cancer

Treatment of Patients with Metastatic Melanoma by Lymphodepleting Conditioning Followed by Infusion of Anti-MART-1 TCR-Gene Engineered Lymphocytes and Subsequent Peptide Immunization

Development and Evaluation of Techniques for Computer Aided Detection and Diagnosis from Radiologic Images

Phase II Study of the Efficacy and Toxicity of Ontak (Denileukin Diftitox) in the Therapy of Adult T-Cell Leukemia

Phase I Study of BL22, a Recombinant Immunotoxin for Chronic Lymphocytic Leukemia and CD22+ Lymphomas

A Phase II Study of Campath-1H in Children with Acute Lymphoblastic Leukemia in Second or Refractory Relapse

A Phase I Trial of CC-5013 (Lenalidomide) in Pediatric Patients with Recurrent or Refractory Primary CNS Tumors

Randomized Phase II Study of Dose-Adjusted EPOCH-Rituximab-Bortezomib (EPOCH-R-B) Induction Followed by Bortezomib Maintenance versus Observation in Untreated Mantle Cell Lymphoma with Microarray Profiling and Proteomics

Phase III Randomized Study of R-CHOP v. Dose-Adjusted EPOCH-R with Molecular Profiling in Untreated de Novo Diffuse Large B-Cell Lymphomas

A Randomized Study of Electroacupuncture Treatment for Delayed Chemotherapy-Induced Nausea and Vomiting in Patients with Pediatric Sarcomas

Evaluation of Efficacy and Mechanisms of an Antiinflammatory Intervention for Chemotherapy Related Mucosal Injury

Genetic Analysis of Hereditary Prostate Cancer

Procurement of Normal Breast Tissue and Metastatic Breast Cancer Tissue for Molecular Profiling

Urinary and Serum VEGF and MMP Levels in Patients Receiving Radiation Therapy for Glioblastoma Multiforme: Prospective Determination of a Predictive Value for Recurrence

A Prospective Histopathologic Study of Dynamic Contrast Enhanced MRI for Prostate Cancer Delineation and Characterization with the APT-MRI System

Phase II Study of UCN-01 in Relapsed or Refractory Systemic Anaplastic Large Cell and Mature T-Cell Lymphomas

Treatment of Patients with Metastatic Melanoma by Lymphodepleting Conditioning Followed by Infusion of TCR-Gene Engineered Lymphocytes and Subsequent Peptide Immunization

Barrett's Esophagus Early Detection Study

Pancreas Resection for the Procurement of Tissue in Patients with Suspected Pancreas Malignancy

Allogeneic Breast Protocol 2: Phase I Trial of T cell Exchange with Th2/Tc2 Cells for Allogeneic Stem Cell Transplantation after Reduced Intensity Conditioning for Metastatic Breast Cancer

A Phase II Trial Combining Estramustine, Docetaxel and Thalidomide in Patients with Androgen-Independent Metastatic Prostate Cancer

Treatment of Patients with Metastatic Melanoma using Lymphocytes Reactive with the gp100 Antigen and Immunization using a recombinant rF-gp100P209 Virus Encoding a gp100 Peptide Following a Nonmyeloablative Lymphocyte Depleting Regimen

A Pilot Study of a Three Month Intervention for Increasing Physical Activity in Sedentary Women at Risk for Breast Cancer

A Phase II Clinical Trial of Anti-Tac(Fv)-PE38 (LMB-2) Immunotoxin for Treatment of CD25 Positive Cutaneous T-Cell Lymphomas

A Phase II Trial of O6-Benzylguanine and Temozolomide in Pediatric Patients with Recurrent or Progressive High-Grade Gliomas and Recurrent or Progressive Brainstem Tumors

A Study of the Safety, Tolerability, and Pharmacokinetics of MORAb-009, A Chimeric Monoclonal Antibody, in Subjects with Advanced Mesothelin-Expressing Tumors

Phase I and Pharmacokinetic Study of BAY 43-9006 (Sorafenib) in Patients with Kaposi's Sarcoma

A Pilot Pediatric/Adult Study of Gene Expression Profiling and Clinical Characterization of Phototoxicity

A Phase 1 Study of the Safety and Efficacy of GC1008: A Human Anti-Transforming Growth Factor-Beta (TGFB) Monoclonal Antibody in Patients with Advanced Renal Cell Carcinoma or Malignant Melanoma

A Phase I Trial of TNF-Bound Colloidal Gold (CYT-6091) by Intravenous Administration in Subjects with Advance Solid Organ Malignancies

The Characterization of CD34+ Derived Mast Cell Precursors Mobilized by Administration of Granulocyte Colony Stimulating Factor

Outcomes of Education and Counseling for HNPCC Testing

A Phase II Study to Evaluate the Efficacy and Safety Using Combined Monoclonal Antibodies, Trastuzumab and Pertuzumab in Subjects with HER-2 Overexpressed Locally Advanced and Metastatic Breast Cancer

A Phase II Clinical Trial of the Histone Deacetylase Inhibitor Valproic Acid in Combination with Temodar and Radiation Therapy in Patients with High Grade Gliomas

Targeted Oncolytic Virotherapy and Natural History Study of KSHV-Associated Multicentric Castleman's Disease with Laboratory and Clinical Correlates of Disease Activity

A Phase I/II Trial of Depsi-Peptide in Patients with High-Grade Gliomas

Phase I Trial of a PSA based Vaccine and an anti-CTLA-4 Antibody in Patients with Metastatic Androgen Independent Prostrate Cancer

A Phase I Study of 17-Dimethylaminoethylamino-17-Demethoxygeldanamycin (17-DMAG) with Evaluation of HSP-90 Client Proteins in Patients with Solid Tumors and Lymphomas

A Phase II Trial of Isolated Hepatic Perfusion (IHP) with Melphalan for Subjects with Metastatic Unresectable Colorectal Cancers of the Liver with Disease Refractory to First Line Systemic Chemotherapy

A Phase I Study of the RAF Kinase and Receptor Tyrosine Kinase Inhibitor Sorafenib (BAY 43-9006, NSC# 724772 IND# 69896) in Children with Refractory Solid Tumors or Refractory Leukemias

A Pilot Study of Anti-Tac(Fv)-PE38 (LMB-2) Immunotoxin for Treatment of CD25 Positive Hodgkin's Disease after Fludarabine and Cyclophosphamide.

Phase II Trial Using Aldesleukin (lL-2) Following a Lymphodepleting Chemotherapy and Reinfusion of Autologous Lymphocytes Depleted of T Regulatory Lymphocytes in Metastatic Melanoma

A Pilot Trial of Oral Topotecan for the Treatment of Refractory Advanced Solid Neoplasms Expressing HIF-1 Alpha

Long-Term Evaluation and Follow Up Care of Patients Treated with Allogeneic Stem Cell Transplants

A Pilot Study of Alemtuzumab (Campath) in Patients with Myelodysplastic Syndrome (MDS)

A Phase I Trial of a CEA-TRICOM Based Vaccine and Radiation to Liver Metastasis with or without Celecoxib in Patients with CEA Positive Solid Tumors

Two-Compartment Model of Diffusion Tensor Magnetic Resonance Imaging (DT-MRI) for the Diagnosis of Glioma Tumor Recurrence versus Radiation Necrosis

A Phase II Randomized Study of the Effect of Zoledronic Acid Versus Observation on Bone Mineral Density of the Lumbar Spine in Women Who Elect to Undergo Risk-Reducing Surgery that Results in the Removal of Both Ovaries

Studies on the Mechanism of Action of High-dose IL-2 in Metastatic Melanoma and Renal Cell Cancer

A Pilot Study to Investigate the Safety and Immunogenicity of a Peptide Vaccine for HIV Infected HLA-A2 Individuals Designed to Impede the Development of Antiretroviral Resistance

An Exploratory Study of Biologic and Pathophysiologic Effects of Radiation Therapy in Pediatric Patients with Central Nervous System Tumors

A Phase I Trial of 5-Fluoro-2-Deoxycytidine with Tetrahydrouridine in Advanced Malignancies

Evaluation of the Impact of Adjuvants Accompanying Peptide Immunization in High Risk Melanoma

A Phase I Pharmacokinetic and Pharmacodynamic Study of Temsirolimus (CCI-779) in Patients with Advanced Malignancies and Normal and Impaired Liver Function: An NCI Organ Dysfunction Working Group Study

A Phase II Trial of BEVACIZUMAB for Patients with Recurrent High-Grade Gliomas

A Phase I/II Trial of ZD6474 for Patients with Recurrent High-Grade and Progressive Low-Grade Gliomas

Phase II Study of Bay 43-9006 (Sorafenib) with Evaluation of RAS Signal Pathway in Patients with Relapsed Non-Small Cell Lung Cancer

Phase I Trial of Intravenous Fenretinide (4-HPR) for Patients with Hematologic Malignancies

Phase I Dose Escalation Study of the EGFR Tyrosine Kinase Inhibitor Gefitinib

Pediatric Phase I Trial of LMB-2 for Refractory CD25-Positive Leukemias and Lymphomas

A Phase 0 Pharmacokinetic, Pharmacodynamic Study of ABT-888, an Inhibitor of Poly (ADP-ribose) Polymerase (PARP), in Refractory Solid Tumors and Lymphoid Malignancies

Genetic Analysis of Gray Platelet Syndrome

Prospective Assessment of Clinical and Biological Factors Determining Outcomes in Patients with Chronic Graft-Versus-Host Disease

Peripheral Blood Mobilized Hematopoietic Precursor Cell Transplantation Followed by T Cell Add-Back for Hematological Malignancies - Effect of Peritransplant Cyclosporine on Chimerism

Phase I Study of CDDO in Solid Tumors and Lymphomas

Phase I Trial of AZD2171, an Orally Bioavailable Antiangiogenic Agent, in Children and Adolescents with Refractory or Recurrent Solid Tumors or Acute Myelogenous Leukemia

Treatment of Patients with Metastatic Melanoma Using a Transplant of Autologous Lymphocytes Reactive with Tumor Following a Meyloablative Lymphocyte Depleting Regimen of Chemotherapy, Total Body Irradiation and Reconstitution with CD34+ Cells

Characterization of the Pathogenesis of Lymphangioleiomyomatosis (LAM)

A Phase I/II Study of HLA-Matched Peripheral Blood Mobilized Hematopoietic Progenitor Cell Transplantation for Metastatic Renal Cell Carcinoma Followed by Allogeneic T-Cell Infusion as Adoptive Immunotherapy

A Pilot Study of the Safety and Efficacy of Imatinib in Reducing Monocytosis or Leukocytosis in Patients with Chronic Myelomonocytic Leukemia and Atypical Chronic Myelogenous Leukemia, Respectively

Dermoscopic Diagnosis, Histopathological Correlation, and Cellular Immortalization of Melanocytic Nevi and Primary Cutaneous Melanoma

Randomized Trial of Patient-Specific Vaccination with Conjugated Follicular Lymphoma-Derived Idiotype with Local GM-CSF in First Complete Remission

A Phase I/II Study of ATN-161 and Carboplatin in Adult Patients with Recurrent Intracranial Malignant Glioma

Comprehensive Epitope Mapping of the Epstein-Barr Virus Latent Membrane Protein-2 in Ethnically Diverse Populations

A Multi-Institutional Study of Proteomic Evaluation of Epithelial Ovarian Cancer, Primary Peritoneal Cancer, and Fallopian Tube Cancer Patients in First Clinical Remission: Development of a Protein Fingerprint Profile of Relapse

Treatment of Patients with Metastatic Renal Cell Cancer Using Cultured Tumor-Reactive Lymphocytes and Interleukin-2

A Phase II Study of Hepatic Arterial Infusion of Melphalan with Venous Filtration via Peripheral Hepatic Perfusion (PHP) for Unresectable Primary and Metastatic Cancers of the Liver

Diagnosis, Pathophysiology, and Molecular Biology of Pheochromocytoma

A Phase I Dose Escalation Study of Heat Activated Liposome Delivery of Doxorubicin and Radiofrequency Ablation of Primary and Metastatic Tumors of the Liver

A Phase II Trial of BAY 43-9006 (Sorafenib) in Metastatic, Androgen-Independent Prostate Cancer

Cutaneous Tumorigenesis in Patients with Tuberous Sclerosis

Phase I Study of Sequential Depsipeptide Flavopiridol Infusion in Patients with Malignancies Involving Lungs, Esophagus, or Pleura

A Phase I Trial and Pharmacokinetic Study of Talabostat (PT-100, VAL-BORO-PRO) in Combination with Temozolomide or Carboplatin in Pediatric Patients with Relapsed or Refractory Solid Tumors Including Brain Tumors

Phase II Evaluation of RFT5-dgA in Patients with Metastatic Melanoma

Phase II Study Using a Myeloablative Lymphocyte Depleting Regimen of Chemotherapy and Intensive Total Body Irradiation Followed by Infusion of Tumor Reactive Lymphocytes and Reconstitution with CD34+ Stem Cells in Metastatic Melanoma

A Random-Assignment Study of Hepatic Arterial Infusion of Melphalan with Venous Filtration via Peripheral Hepatic Perfusion (PHP) (Delcath System) Versus Best Alternative Care for Ocular and Cutaneous Melanoma Metastatic to the Liver

Phase II Study in Metastatic Melanoma or Kidney Cancer using Autologous Natural Killer Cells Plus Aldesleukin (IL-2) Following a Lymphodepleting Chemotherapy

Microarray Analysis of the Effect of Cyclosporine Therapy on Gene Expression Patients in Large Granular Lymphocytic Leukemia

A Phase II Study of BAY 43-9006 (Sorafenib) in Combination with Cetuximab (Erbitux) in EGFR Expressing Metastatic Colorectal Cancer (CRC)

Bevacizumab as an Adjuvant for Resectable Ductal Adenocarcinoma of the Pancreas

Metoclopramide to Treat Anemia in Patients with Myelodysplastic Syndrome (MSD)

A Phase II Clinical Trial of Anti-Tac(Fv)-PE38 (LMB-2) Immunotoxin for CD25 Positive Hairy Cell Leukemia

A Phase I Feasibility Study of an Intraprostatic PSA-Based Vaccine in Prostate Cancer Patients with Local Failure Following Radiotherapy

A Randomized Phase II Study of Fixed Dose Ioilimumab (MDX-0101) 10mg/kg Given Alone or in Combination with Two gp100 Peptides Emulsified with Montanide ISA-51 for Previously Treated HLA-A 0201 Positive Subjects with Stage IV Melanoma

Comprehensive Prostate MRI for the Evaluation of Prostate Cancer at 3:OT: A Pilot Study

Evaluation of a Novel Blood Test of Hypercoagulability in Surgical Patients with Metastatic Carcinoma: a Pilot Study

Last updated: September 15, 2006 at 4:30:37 PM