Research Center Profile:
Michigan Head-Pain & Neurological Institute
Head-Pain & Neurological Institute (MHNI), the nation’s
first comprehensive head pain treatment and research center, was
founded by Dr. Joel Saper in 1978 to provide intensive, balanced
treatment of headache and other painful disorders. The Institute is
the only center of its kind to be accredited by both the Joint
Commission on Accreditation of Healthcare Organizations (JCAHO,
and the Commission on Accreditation of Rehabilitation Facilities
(CARF, www.CARF.org). On-site neurodiagnostic and
laboratory services are available to MHNI patients. Testing is
performed by highly qualified licensed technicians and interpreted
by physician specialists at the Institute. The Laboratory Division
is fully accredited by the Commission on Office Laboratory
Accreditation (COLA, www.COLA.org) and has been repeatedly
recognized for its commitment to excellence in laboratory
For over three decades the Institute has been focused on addressing the needs of patients with headache and other painful illnesses, and neurological disorders through advanced clinical care, research, and health education.
Please refer to our main web site at
a full description of the services provided at MHNI. Selected
information is available on this web site and can be accessed by
clicking the hyperlink above. You may also
us by email with any questions or for an appointment with our
MHNI has been involved in over 500 research and clinical trials since its inception in 1978.
Division of MHNI continues to focus on the following therapeutic areas:
PEDIATRIC AND ADOLESCENT MIGRAINE, ACUTE AND CHRONIC
ADULT ACUTE AND CHRONIC MIGRAINE
CARPAL TUNNEL SYNDROME
INSOMNIA AND OTHER SLEEP DISORDERS
OTHER CHRONIC PAIN DISORDERS
The Institute has conducted clinical trials with pharmaceutical industry sponsors that include Abbott, Allergan., AstraZeneca , Bristol-Myers Squibb, Capnia, Cephalon, Cypress, Carnick, CoCensys, Eisai, Elan, Endo, Forest, GlaxoSmithKline, Janssen, R.W. Johnson, Eli Lilly, Map Pharmaceuticals Merck, NBI, NPS, Novartis, Ortho-McNeil, Parke-Davis, Pfizer, Pozen, Purdue Pharma, RPR, Sandoz, Schwarz,Searle, Takeda, TorreyPines, ucb Pharma, Vanda, Vernalis, Winston, and others. The Institute has also conducted medical device trials with Boston Scientific, Medtronic and St. Jude Medical.
Michigan HeadPain & Neurological Institute is located in Ann
Arbor, surrounded by the University of Michigan, Eastern Michigan
University, and Washtenaw Community College. We include the local
academic community as well as the greater Detroit metropolitan area
in our research patient population. The Institute is located 23
miles from the Detroit Metro Airport, and has spacious free
MHNI campus includes 20 clinical examination rooms, acute care
accommodations, procedure rooms for infusion and interventional
treatment, physical therapy, laboratory, behavioral medicine, and
neurodiagnostic facilities and staff. The Institute maintains
strict confidentiality and security standards compliant with CARF
and JCAHO requirements. The multidisciplinary team of professionals
at MHNI includes specialists in Neurology, Internal Medicine,
Anesthesiology, and Psychology / Neuropsychology (PhDs), as well as
Physical Therapists, Physician Assistants, Registered Nurses,
Medical Technologists (ASCP), and Psychometrician.
MHNI Clinical Research Division provides:
Physician Investigators and Sub-Investigators on-site Monday
Experienced full-time RN Study Coordinators
Contract and Budget Facilitator
Extensive Subject Database with Cross-Reference Capability
Prompt / Accurate Data Entry
Computerized Scheduling and Patient Tracking
Customized Source Documents
Dedicated Monitor Office
Utilization of Central IRBs
Joel R. Saper, M.D., F.A.C.P.,
Founder and Director of the Institute and the inpatient Head Pain Treatment Unit at Chelsea Community Hospital. Dr. Saper has been a Principal Investigator in over 200 studies and has over 30 years of experience in original research and sponsored clinical trials. Board certified in both Neurology and Pain Medicine, Dr.Saper’s work is widely published in peer reviewed journals and professional literature.
Charles David Gordon, MD, formerly at the John R. Graham Headache Center in Boston, has been with MHNI since 1990. He has served as Principal Investigator in clinical trials for Acute Migraine in adolescents, Migraine Prophylaxis in adults, and Osteoarthritis of the knee, as well as Sub-Investigator and Cardiac Consultant for many additional studies.
Alvin E. Lake III, PhD, is Senior Research Psychologist and
Director of the Behavioral Medicine Division at MHNI. He has
extensive training and experience in protocol development,
statistical analysis, and data reporting, all utilized in Institute
clinical and program outcome studies. Dr. Lake has achieved both
national and international recognition for his clinical work and
James R. Weintraub, DO, a board-certified Neurologist and Sleep
Disorders Specialist, came to MHNI in 1995. He is Principal
Investigator in studies of Diabetic Neuropathy, Post-Herpetic
Neuralgia, and other painful neuropathic conditions, and Insomnia
and other Sleep Disorders. Dr. Weintraub is also an active
Sub-Investigator in chronic and acute headache treatment
Alicia R. Prestegaard, MD, is board certified in both Neurology
and Pain Medicine. She also completed a fellowship in
electromyography. Dr. Prestegaard’s focus in clinical trials, as
well as clinical practice, is the treatment of Recurrent Headache
and other Chronic Pain Conditions.
Shamas Moheyuddin, MD, completed his residency in Anesthesiology
and a Fellowship in Interventional Pain Management before coming to
MHNI in 2005. In addition to his clinical practice of invasive and
non-invasive treatment options for a wide range of painful
disorders, he is currently involved in studies evaluating
Peripheral Nerve Stimulation for the treatment of Chronic
For more information on our investigators please click
Marjorie Winters, R.N., Division Director,
Research & Education, has over 15 years of experience in
directing MHNI staff original clinical studies and coordinating
industry sponsored pharmaceutical trials. She facilitates budget
and contract processes, and serves as clinical / administrative
Shawn Szalay, RN, CCRP, had experience in
Clinical Drug Safety Monitoring before coming to MHNI in 2002 to
become Manager of Pharmaceutical Trials. She oversees staff
training, and has developed a successful subject recruitment
program resulting in meeting or exceeding enrollment goals well
within target timelines.
Amy Amazeen joined the staff at MHNI in 2001.
Her specialty is ‘Study Start-Up’ , Regulatory Documents, and data
entry in a variety of RDC programs.
Jennifer Majestic, RN, CCRP on staff at MHNI since
2002, has been primary Study Coordinator for clinical trials in
Acute and Chronic Migraine, Health Economics, Post-Herpetic
Neuralgia, and others.
Anita Severance, RN has been with the institute since 2006 and has been a research coordinator since 2011. She has been a primary coordinator on clinical trials in Migraine, Diabetic Neuropathy, Cluster Headaches, and Multiple Sclerosis.
For more information on our staff please click
The Research Division of MHNI draws from a population of
pediatric, adolescent, adult, and geriatric patients primarily in
the southeastern region of Michigan, northwest Ohio, and northeast
Indiana; a population base of over 6 million. The clinic provides
over 20,000 visits per year to headache and pain patients
nationwide; depending on the parameters of the study, research
participants may be drawn from this population as well.
If you are interested in contacting this center to discuss placing a clinical
trial there, please complete and send the email form below. A representative from
the research center will then follow up with you.