Research Center Profile:
CNS Research of RI, Inc.

Center Information

Patricia J. Epple, RN, BSN, CCRC, Sr. CRA
Research Director and President
CNS Research of RI, Inc.
P.O. Box 4563
Providence, RI 02906
1-800-707-6013 Ext. 101
1-800-847-4332 (fax)

Contact Center

Therapeutic Areas


Center Overview

CNS Research Inc. was founded in 1997 and is a multi-site PPPN, (Private Practice Physician's Network). Our goal is to provide the best possible patient care by offering sophisticated and diverse pharmacological research opportunities with medications not available to the general public. Working with pharmaceutical companies, we provide cutting edge evaluations, treatment and education of central nervous systems disorders.

Performance Metrics

Number of Studies Conducted: 200
Number of Studies Actually Completed: 180
Number of Active Patients in the Database: 10000
Regulatory Submission Turn-Around Time: 9 Week(s)
Average Number of Total Patients Enrolled: 2000
Average Percent of Total Patients Randomized: 90%
Average Percent of ‘Completed’ Studies that met Enrollment Goals: 80%
EDC Capabilities: Yes

Clinical Research Experience

We focus on phases II & III clinical trials. Therapeutic areas are Alzheimer's Disease, Epilepsy, Migraine Headaches, Multiple Sclerosis, Diabetic Neuropathic Pain and Stroke. Our investigators have successfully been conducting studies with the following pharmaceutical companies:

Alzheimer’s Disease

Sponsor Drug Name Phase Protocol Enrollment Commitment Completed Patients
Eli Lilly Olanzepine II FID-US-HGIC-008 10 8
Janssen Galantamine III GAl-USA 10-18 63 55
Neurochem Alzhemed III CL – 758007 12 23
Novartis Exelon IIII CENA713BUS13 8 11
ONO N/A/ II ONO-2506 8 8

Migraine Headaches

Sponsor Drug Name Phase Protocol Enrollment Commitment Completed Patients
J&J PRI Topamax III MIG-002 08 15
AstraZeneca Zomig III 311CUS/0022 10 12
GSK Sumatriptan III SUM40299 08 09


Sponsor Drug Name Phase Protocol Enrollment Commitment Completed Patients
J&J PRI Topamax III EPMN-106 10 06
Élan Zonegran III AN46046-304 06 09
GSK Lamictal III LAM40124 06 03

Multiple Sclerosis

Sponsor Drug Name Phase Protocol Enrollment Commitment Completed Patients
Teva Copaxone II Copolymer 10 6
Peptimmune Cytokine II MS-001 20 24
Biogen BG-12 Define III 109-MS-301 6 4
Biogen BG-12 Endorse III 109-MS-303 2 2
Novartis Gilenya IIII CFTY720DUS01 6 4

Diabetic Neuropathic Pain

Sponsor Drug Name Phase Protocol Enrollment Commitment Completed Patients
J&J PRD Topamax III NP-001 10 07
SANKYO Fidaristat II SNK-860-201 06 03


Sponsor Drug Name Phase Protocol Enrollment Commitment Completed Patients
Park-Davis Fosphenytoin II N/A 10 08
ONO ONO-2506 II ONO-2506 08 06
BMS II N/A 10 07
Yamanuchi YM 872 II YM 872 06 04

Facility Description

We have a network of independent, private practice neurologists located in Rhode Island, Massachusetts and Connecticut. Through this network, CNS Research has established in-depth trust with these independent sites and their capabilities. We have a track record with each site across all CNS disease areas. We have historical knowledge as to patient recruitment techniques that are appropriate and successful in the local community in which the site is located. All this information results in CNS Research’s ability to start studies quicker and complete studies as scheduled.

Investigator Experience

Our Private Practice Physician's network is comprised of seven leading neurologists:

  • Dr. Norman M. Gordon
    Medical Director of CNS Research, Inc.
    Dr. Norman Gordon received his medical degree from the University of the Witwatersrand in Johannesburg, South Africa. He completed an Internal Medicine Residency at the Miriam Hospital in Providence, Rhode Island. Dr. Gordon completed a Neurology Residency at the RIH Department of Neurology, serving as Chief Resident from 1987-1988. Dr. Gordon is certified by the American Board of Psychiatry and Neurology and the American Board of Internal Medicine. He is a member of the American Academy of Neurology, the Rhode Island Medical Society, and the American Association for the Study of Headache.
  • Dr. Elaine C. Jones, MD, FAAN
    Dr. Elaine Jones attended Brown University in Providence, RI for her Neurology Residency and a Fellowship in Neurophysiology. In 2000 she became Chief of Neurology at Roger Williams Medical Center until 2005 when she left to open her own private practice in Bristol, RI. From 2008 to 2010 she was president of the medical staff at Roger Williams Medical Center and was directly involved as the physician representative for the establishment of a new company CharterCare that merged two local hospital organizations into one corporation. She remains on the Board of Trustees of CharterCare. She became involved in advocacy and health care legislation when she took over as president of the RI Neurological Society. In 2009 she became co-chair of the AAN’s new Government Relations Committee and joined the BrainPAC Executive Board. Recently Dr. Jones became Secretary for the RI Medical Society. Her interest in advocacy remains a strong part of her practice of medicine. She continues to advocate for her patients with pharmacies, health insurance agencies and on the local and national level.
  • Dr. Peter Bellafiore
    Dr. Peter J. Bellafiore offers diagnosis and treatment of general neurological conditions and disorders. Dr. Bellafiore is a physician who is highly trained to treat disorders of the nervous system, which include diseases of the brain, spinal cord, nerves, and muscles. Some of the more common conditions that a neurologist diagnoses and treats are as follows: Strokes Epilepsy (seizures) Headaches, Dementias (Alzheimer's disease), Multiple sclerosis, Parkinson's disease, Various forms of pain Dr. Bellafiore has expertise in the latest neurological technology and innovations. He emphasizes patient education and encourages patients to share in decision making.
  • Dr. Fred Griffith, MD
    Dr. Fred Griffith received his Medical Doctorate from the University of Rochester School of Medicine and Dentistry in 1978. He completed his residency at the New England Medical Center in Boston.
    Area of Expertise: Internal Medicine, Neurology
  • Staff Expertise

  • Patricia Epple, RN, BS, CCRC
    Research Director
    Patricia J. Epple earned her Certification as a Clinical Research Coordinator as the site manager of the Department of Neurology at the Miriam Hospital. With her twenty years experience in the healthcare industry, she has been managing clinical research trials for over 15 years. Her responsibilities include acquisition of new clinical trials, budget negotiations, promotion and supervision of ongoing projects. Patricia is currently the Director of the Stroke Team at Miriam Hospital, responsible for enrolling patients under emergency conditions.
  • Annette M. Phillips, RN, BSN
    Research Coordinator
    Annette received her Bachelor of Science of Nursing from Northeastern University, Boston, MA in 2001 Her experience includes Respiratory disease management acute and chronic, Cardiac Care, Pre and Post-Operative care inpatient and outpatient. Annette has been working with CNS Research Inc. since 2006 on several neurology studies. Her duties include Medical record reviews, data abstraction, to improve clinical outcomes and patient education.
  • Axel J. Epple, MBA
    Project Manager
    Mr. Epple received his MBA from the FHW in Pforzheim, Germany in 1985. He started his career in marketing and sales in Switzerland in the export of industrial products to overseas markets. In 1990 he founded an Export Management Consulting firm in Providence, RI. Mr. Epple has been directing ARISTO Marketing Corporation as Vice President successfully for seven years. In 1997 the Epples founded CNS Research, Inc. with Dr. Norman M. Gordon as the Medical Director. Today Mr. Epple carries out the duties of business manager overseeing studies and consulting projects at several investigative sites.
    RESUME LinkedIn
  • Patient Demographics

    Our affiliation with Southeastern New England's largest Academic Medical Centers allows us to draw patients from Rhode Island, Eastern Massachusetts, and Connecticut. Community based services such as "Memory and Cognitive Disorders Assessment Service" offer the most comprehensive clinic in the region for evaluation of memory loss.

    Contact Center

    If you are interested in contacting this center to discuss placing a clinical trial there, please complete and send the email form below. A representative from the research center will then follow up with you.