Premiere Oncology is a center of excellence dedicated to
treating cancer by providing comprehensive and holistic clinical
care with attention to issues of survivorship and longevity. The
group conducts meaningful oncology research with responsibility and
integrity. The aim of the research program is to offer the hopes
and benefits of cutting edge treatment to patients while generating
data of the highest quality. Premiere Oncology is also committed to
educating future healthcare leaders in oncology practice and
research and providing community education on cancer prevention and
treatment opportunities.
In 2004, Lee S. Rosen, M.D. created Premiere Oncology to
continue the research he began in 1996 as founder of the
Developmental Therapeutics Program at the University of California,
Los Angeles (UCLA). Dr. Rosen specializes in the treatment of
gastrointestinal and other solid tumors. He is an avid researcher
and has been Principal Investigator of pivotal clinical trials of
products approved by the United States Food and Drug Administration
(FDA) for the treatment of cancer, including Sutent®, Camptosar®,
Eloxatin® and Zometa®. Premiere Oncology is located in Santa
Monica, California where it is affiliated with the Saint John's
Health Center and the John Wayne Cancer Institute.
Premiere Oncology conducts Phase 1, 2 and 3 clinical trials. We
offer a wide array of studies for the treatment for all advanced
malignancies. We work collaboratively with clinicians across the
country to provide their patients with innovative treatments that
bridge the gap between established and future therapies. Sponsors
with which we have worked include: Amgen, Amplimed, Antigenics,
ArQule, Astra Zeneca, Attenuon, Biogen IDEC, Beohringer-Ingelheim,
Bristol Myers Squibb, CancerVax, CovX, Dynavax, Eisai, Exelixis,
Genentech, Hana Biosciences, Infinity Pharmaceuticals, Kosan,
Nektar, Neopharm, Novacea, Peregrine, Pfizer, Raven,
Sanofi-Aventis, SGX, SuperGen, Synta, Tempol, Taiho, Tracon, Wyeth,
and Ziopharm. These relationships help to ensure that Premiere
Oncology has access to the most exciting products being developed
for the treatment of cancer.
Premiere Oncology is located across the street from St.
John's Health Center and the John Wayne Cancer Center in Santa
Monica, a 30-minute drive from Los Angeles International Airport.
Our state of the art facility with views of the Pacific Ocean
provides comprehensive cancer treatment. Our center has its own
research laboratory and an investigational pharmacy with secure
drug storage, fume hoods, high speed centrifuges, -20F, -30F, and
-80F freezers, private study monitor areas, computer internet
access, patient library and research patient waiting room designed
to ease patient participation in research studies.
Lee S. Rosen, MD has a reputation for
excellence in the conduct of early stage clinical trials for
patients with solid tumors and treatment of patients with
gastrointestinal malignancies. He received his B.A. in
English Literature from Yale University, a Masters of Public Policy
(M.P.P.) from Harvard University’s John F. Kennedy School of
Government and his Medical Degree from Baylor College of Medicine
in Houston, Texas.
Dr. Rosen is a principal investigator for many clinical trials
focusing on new cancer drug development (Phase 1). Formerly
Assistant Professor in the Division of Hematology-Oncology,
Department of Medicine at the University of California, Los Angeles
(UCLA), he founded the Developmental Therapeutics Program, a cancer
research initiative focused on new drug development. Dr.
Rosen has made significant contributions to translational research
with angiogenesis inhibitors (a new class of drugs developed to
treat cancer by inhibiting development of new blood vessels),
signal transduction inhibitors and innovative drug
combinations.
As a result of his Phase 1 experience, Dr. Rosen has developed
skills pertinent to the treatment of thyroid cancer, sarcomas, and
other rare solid tumor types that do not have United States Food
and Drug Administration (FDA) approved treatments available.
He has led pivotal clinical trials of many products subsequently
approved by the FDA for the treatment of cancer including Camptosar
(irinotecan HCL injection), Eloxatin (oxaliplatin), Zometa
(zoledronic acid for injection) and Sutent (sunitinib
malate). In the year 2000, his work with angiogenesis
inhibitors was featured on the CBS television program 60
Minutes. He has since treated hundreds of patients with more
than a dozen drugs in this class.
Linnea Chap, MD is a highly respected
specialist in cancers affecting women. She received her medical
degree from the University of Chicago, completed her residency in
internal medicine at Northwestern Memorial Hospital and her
fellowship in both Hematology and Medical Oncology at UCLA. She
joined the faculty at UCLA in 1995 serving most recently as
Associate Professor of Medicine and co-director of the UCLA/Revlon
Multidisciplinary Breast Center, overseeing the Multidisciplinary
Breast Clinic. Dr. Chap has multiple publications to her credit and
has led several breast and ovarian cancer treatment protocols,
including the pioneering use of novel biologic agents such as
Herceptin and Avastin.
In 2001, Dr. Chap was named one of "America's Top
Breast Cancer Doctors" by Redbook, a national women's
magazine. Annually, she has also been listed as one of
"America's Top Doctors for Cancer". Recognized for
her teaching and speaking skills, Dr. Chap has a national
reputation where she is frequently called on to relate the most
recent advances in breast cancer treatment.
Jonathan Goldman, MD graduated magna cum laude
from Harvard University and received his medical degree from
Stanford University. He completed his residency in internal
medicine at University of California San Francisco and his
fellowship in both hematology and medical oncology at UCLA.
In addition to seeing all types of hematology and oncology
patients, Dr. Goldman will be developing a multidisciplinary
thoracic malignancy program in our community.
Premiere Oncology's research staff has a cumulative total of
more than 50 years' experience in clinical research, including
contracts, budget development, study coordination, and data
management.
