Mast Therapeutics

Mast Therapeutics, Savara to merge

Monday, January 9, 2017

Mast Therapeutics and Savara, a privately held emerging specialty pharmaceutical company focused on the treatment of rare respiratory diseases, have entered into a definitive merger agreement under which the stockholders of Savara would become the majority owners of Mast, and the operations of Mast and Savara would be combined. Subject to stockholder approval, the combined company will advance a pipeline of novel inhalation therapies for the treatment of diseases with significant unmet medical needs, featuring three product candidates, each in advanced clinical development.  

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Mast Therapeutics initiates phase II vepoloxamer study

Monday, October 26, 2015

San Diego-based Mast Therapeutics, a clinical-stage biopharmaceutical company leveraging its molecular adhesion and sealant technology (MAST) platform to develop novel therapies for sickle cell disease, heart failure, and stroke, has initiated its phase II study of vepoloxamer for the treatment of patients with chronic heart failure. [Read More]

Mast to develop Vepoloxamer (MST-188) in chronic heart failure

Friday, March 27, 2015

Mast Therapeutics, a clinical-stage biopharmaceutical company leveraging its molecular adhesion and sealant technology (MAST) platform to develop novel therapies for sickle cell disease, arterial disease and heart failure, plans to develop vepoloxamer (MST-188) for the treatment of patients with chronic heart failure. Encouraged by recently reported nonclinical results and input from experts in the field, the company expects to begin dosing in a phase II study of vepoloxamer in patients with chronic heart failure in the third quarter of this year.

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Mast Therapeutics to acquire Aires Pharmaceuticals

Monday, February 10, 2014

Mast Therapeutics has entered into a definitive agreement to acquire Aires Pharmaceuticals, a privately-held, clinical stage pharmaceutical company developing therapies to treat pulmonary vascular disorders such as pulmonary arterial hypertension and pulmonary hypertension due to heart failure. Aires’ lead product, AIR001, is an intermittently nebulized formulation of nitrite and has Orphan Drug status with the FDA and the EMA for the treatment of pulmonary arterial hypertension.

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