Arrowhead Pharmaceuticals

Arrowhead doses first patient with hepatitis B in phase I/II ARC-521study

Thursday, September 8, 2016

Arrowhead Pharmaceuticals has dosed the first patient in the multiple ascending dose (MAD) portion of its ongoing phase I/II study of ARC-521, the company’s second RNAi-based investigational medicine for the treatment of chronic hepatitis B virus (HBV) infection. To date 24 healthy volunteers have been treated in the study, and the drug safety committee (DSC) approved initiation of the MAD after a planned review of safety data from cohort 3 of the healthy volunteer portion of the study. The MAD is designed to evaluate the safety, tolerability, and antiviral activity of single and multiple doses of ARC-521 in patients with chronic HBV.

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