ArQule Receives FDA IND clearance for BTK inhibitor ARQ 531

Wednesday, April 12, 2017

ArQule has received clearance from the FDA for the Investigational New Drug (IND) application to conduct a phase I clinical trial with ARQ 531 in patients with B-cell malignancies who are refractory to other therapeutic options. ARQ 531 is an investigational, orally bioavailable, potent and reversible inhibitor of both wild type and C481S-mutant Bruton’s tyrosine kinase (BTK).

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ArQule, Beryllium collaborate

Wednesday, May 6, 2015

ArQule, a Woburn, Mass.-based biotechnology company, and Beryllium Discovery, a company using target-centric platforms to provide research services and collaborations to commercial and academic partners, have formed a collaborative R&D agreement to identify and unlock the therapeutic potential of small molecule compounds by combining ArQule’s chemistry and drug development experience with Beryllium’s discovery platforms. The Beryllium platforms integrate structure-guided drug discovery, biophysics and cell biology.

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ArQule, NIH collaborate to develop ARQ 092 in Proteus syndrome

Friday, November 14, 2014

ArQule, a Woburn, Mass.-based biotech company engaged in the R&D of next-generation, small-molecule cancer therapeutics, has formed an agreement with the National Human Genome Research Institute (NHGRI) of the NIH, providing for the clinical development of ARQ 092, an orally available, selective small molecule inhibitor of AKT, in Proteus syndrome, a rare disease characterized by overgrowth of the skeleton, skin, adipose tissue and central nervous system.

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