Aptevo Therapeutics

Aptevo, Alligator to develop tumor-directed immunotherapy bispecific antibody

Monday, July 24, 2017

Aptevo Therapeutics, a biotechnology company focused on developing novel immuno-oncology and hematology therapeutics, and Alligator Bioscience, a biotechnology company developing antibody-based pharmaceuticals for tumor-directed immunotherapy, have entered into an agreement to co-develop a novel immunotherapy bispecific antibody candidate, ALG.APV-527, based on Alligator’s first generation bispecific antibody, ATOR-1016. The new bispecific candidate was developed using Aptevo’s bispecific technology platform and includes proprietary binding elements generated by Alligator’s ALLIGATOR-GOLD antibody library. Initiation of cell line development for the manufacturing of clinical material is expected to begin shortly.

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