R&D Trends

Shire, MicroHealth to address hemophilia A and B patient needs

Tuesday, August 29, 2017

Shire, a biotech leader in rare diseases, announced a collaboration with MicroHealth to support a free and secure care monitoring tool for hemophilia A and B patients with inhibitors and their care teams. MicroHealth, a digital health company co-created by a hemophilia patient, developed the tool, in the form of an app, to help improve hemophilia patient care and outcomes through the ability to set reminders, track, store and selectively share personal health data, including photos and bleed alerts, with care team members. Shire’s collaboration with MicroHealth will help the start-up customize the tool with new features and information specifically for the 5-7% of hemophilia patients with inhibitors. Both companies remain independent in this collaboration and Shire does not have access to any patient, caregiver or other third-party data through this collaboration.

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Dow AgroSciences, TeselaGen expanding advanced biodesign platform for Ag

Monday, August 28, 2017

Innovative use of molecular design technology is essential for discovering and developing new agricultural products at a faster pace. TeselaGen Biotechnology, and Dow AgroSciences, a wholly owned subsidiary of The Dow Chemical, announced they have entered a new phase in their collaboration to produce a state-of-the-art biological design automation platform that can speed discovery work. The companies began collaborating in 2016.

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Topas Therapeutics, Eli Lilly ink agreement on immune tolerance

Friday, August 25, 2017

Topas Therapeutics, a Hamburg, Germany-based private company, has signed a multi-year agreement with Eli Lilly to collaborate in the field of antigen-specific tolerance induction with an initial focus on external antigens thought to induce inflammation and/or autoimmune disease. Topas will be responsible for conducting pre-clinical proof-of-principle studies in collaboration with Lilly to generate drug candidates. Under the terms of the agreement, Lilly has an option for all candidates produced under the collaboration for in-licensing and further development. Topas will receive R&D funding and participate in the future success of any compounds in-licensed by Lilly. Financial details of the collaboration are not being disclosed.

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CRISPR, Massachusetts General Hospital partner on CRISPR/Cas9 in T cell cancer therapies

Thursday, August 24, 2017

CRISPR Therapeutics, a biopharmaceutical company focused on creating transformative gene-based medicines for serious diseases, and Massachusetts General Hospital Cancer Center (MGHCC), a scientific and clinical institution, have entered into a two-year research collaboration and license option agreement to develop novel T cell therapies for cancer. As part of the collaboration, CRISPR/Cas9 gene editing will be utilized to improve upon current T cell therapies in development, ultimately addressing unmet needs in both hematologic and solid tumors. Marcela V. Maus, M.D., Ph.D., director of the Cellular Immunotherapy Program at MGHCC and Assistant Professor of Medicine at Harvard Medical, will lead the scientific work at MGH.

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Ethris, AstraZeneca to develop mRNA therapies for respiratory diseases

Tuesday, August 22, 2017

Ethris, a leader in mRNA-based therapeutics with specific expertise in pulmonary disease, announced a five-year strategic research collaboration with AstraZeneca and its global biologics research and development arm, MedImmune. The collaboration is focused on developing new stabilized non-immunogenic modified RNA therapies for respiratory diseases using Ethris’ proprietary SNIM RNA technology.

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Champions Oncology, AstraZeneca collaborate

Tuesday, August 22, 2017

Champions Oncology, a company engaged in the development and sale of advanced technology solutions and products to personalize the development and use of oncology drugs, announced a strategic collaboration with AstraZeneca to develop novel cohorts of PDX models. These models will be used in AstraZeneca’s oncology R&D programs in breast and lung cancer, in addition to being added to Champions’ existing TumorGraft bank for translational oncology research for academic and industry customers. Champions’ global network of collaborating sites will be leveraged to support this multi-year initiative.

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Champions Oncology, Addario Lung Cancer Medical Institute partner

Friday, August 18, 2017

Champions Oncology, a company engaged in the development and sale of advanced technology solutions and products to personalize the development and use of oncology drugs, announced a collaboration with The Addario Lung Cancer Medical Institute (ALCMI) to develop a novel cohort of PDX models in patients with ROS1 gene rearrangement. These models will further expand Champions’ TumorGraft bank offerings in non-small cell lung cancer for translational oncology research for academic and industry customers. Champions’ global infrastructure will be leveraged to support this multi-year program.

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