« Return to News | Clinical Intelligence

NovaCardia Sees Positive Results with treatment for heart failure

Monday, June 25, 2007 11:04 AM

NovaCardia reported positive preliminary results from a phase III trial of KW-3902 for the treatment of acute congestive heart failure (CHF). This double-blind, randomized trial enrolled 304 subjects with CHF and renal impairment. Subjects received placebo or 10, 20 or 30 milligram doses of intravenous KW- 3902, administered daily for up to three days. All subjects received intravenous furosemide.

The primary endpoint was the proportion of subjects in the categories of treatment success, treatment failure or no change. The 30 mg dose of KW-3902 appeared to be the most efficacious, with higher rates of treatment success and lower rates of treatment failure compared to placebo.

Twenty-four hours post-treatment, self-reported marked or moderate improvement in dyspnea was reported in 66% of the KW-3902 (30 mg) group compared to 51% of the placebo group. No statistically significant differences in adverse events were reported between the groups. The 30 mg dose of KW-3902 was determined to be the optimal dose for NovaCardia’s two 600-subject phase III trials, dubbed PROTECT-1 and PROTECT-2.

Both trials are enrolling subjects in the U.S., Canada, Europe, Israel and Russia.

Share:          
CLINICAL TRIAL RESOURCES

Search:

NEWS ONLINE ARCHIVE

Browse by:

CWWeekly

September 30

Novartis-Walgreens pilot study blurring the line between retail pharmacy, investigative site

CISCRP to launch traveling science museum exhibit to demystify clinical trial participation

Already a subscriber?
Log in to your digital subscription.

Subscribe to CWWeekly.

The CenterWatch Monthly

October

New growth and decline in Asia clinical trials
South Korea, Japan, China see big growth in 1572s, while India posts huge drop

Harnessing Big Data to transform clinical trials
From protocol to patient recruiting, data analytics can yield valuable insights

Already a subscriber?
Log in to your digital subscription.

Purchase the October issue.

Subscribe to
The CenterWatch Monthly.

The CenterWatch Monthly

September

Sponsors look to collaborate on comparator drugs
Co-therapies, comparators are in 60% of studies, cost $25m per company a year

Early adopters implement risk-based monitoring pilot programs
Experiments aim to offer long-term solutions, despite short-term uncertainties

Already a subscriber?
Log in to your digital subscription.

Purchase the September issue.

Subscribe to
The CenterWatch Monthly.

JobWatch centerwatch.com/jobwatch

Featured Jobs

More Jobs

 

Copyright © 1995-2013 CenterWatch.