AstraZeneca, Broad Institute partner on discovery of antibacterial and antiviral agents

Wednesday, September 12, 2012 09:09 AM

AstraZeneca and the Broad Institute in Cambridge, Mass., have formed a collaboration to identify new chemical compounds targeting bacterial and viral infections that could speed the development of new antibacterial and antiviral drugs.

According to the World Health Organization's “Global Burden of Disease” report, infectious and parasitic diseases are the world's second-largest leading cause of death and disability, and the growth of antibiotic-resistant "superbugs" that evade existing treatments is on the rise. However, only two new classes of antibiotics have been introduced to the market in the past 30 years.

Under the two-year collaboration, AstraZeneca and the Broad Institute will work together to address this challenge by bringing together expertise in bacterial genomics and biochemistry with a unique collection of chemical compounds and chemical screening capabilities. Screening and hit-to-lead chemistry will take place in the Broad's chemical biology platform and AstraZeneca will optimize, develop and commercialize potential compounds from identified, high-quality leads.

The chemical library, created at the Broad Institute, comprises 100,000 customized molecules known as diversity-oriented synthesis (DOS) compounds. It is designed to contain molecular shapes and structures not found anywhere else that can hit even the most challenging biological targets.

"We believe new and collaborative approaches between the private and public sectors will help speed the discovery and development of new treatments, particularly for antibiotic-resistant infections,” said Dr. Manos Perros, vice president and head of the infection innovative medicines unit, AstraZeneca. “Through this collaboration we have already identified several new potential projects to pursue."

Share:          
CLINICAL TRIAL RESOURCES

Search:

NEWS ONLINE ARCHIVE

Browse by:

CWWeekly

November 24

Tufts CSDD’s $2.6 billion price tag to develop and bring a new drug to market raises questions, criticisms

Medidata joins GlaxoSmithKline in study to evaluate the impact of wearing mobile devices in clinical trials

Already a subscriber?
Log in to your digital subscription.

Subscribe to CWWeekly.

The CenterWatch Monthly

November

Private equity driving dynamic CRO growth
Enables CROs to pursue long-term strategies, while giving the space credibility

Baby boomers poised to reshape clinical trials industry
Millions of tech-savvy consumers already track their health, expect new treatments as they age

Already a subscriber?
Log in to your digital subscription.

Purchase the September issue.

Subscribe to
The CenterWatch Monthly.

The CenterWatch Monthly

October

CROs driving changes in patient recruitment
Data- and tech-aided enrollment services a competitive advantage

Trials with in-home nurses poised to grow
Higher expense, but may improve recruitment and retention for select trials

Already a subscriber?
Log in to your digital subscription.

Purchase the October issue.

Subscribe to
The CenterWatch Monthly.

JobWatch centerwatch.com/jobwatch

Featured Jobs