Alize Pharma closes $4.1 million funding round

Monday, June 4, 2012 11:14 AM

Alize Pharma, a group of companies developing drugs for the treatment of metabolic diseases and cancer, has completed a funding round of $4.1 million, which will enable the company to move AZP-531, its UAG (UnAcylated Ghrelin) analog, into phase I clinical trials.

Alize Pharma will carry out the first phase I clinical trial of AZP-531 in healthy volunteers in 2013, which will be followed by phase Ib and phase II trials in patients with type 2 diabetes as well as in patients suffering from the Prader Willi syndrome. Preclinical and clinical data suggest that UAG and its analogs have therapeutic potential in the targeted indications, by reducing acylated ghrelin blood levels, improving glycemic control and insulin sensitivity, and improving additional cardiovascular risk factors.

“This development program is extremely important, since it will address significant unmet clinical needs in type 2 diabetes and the Prader Willi syndrome,” said Thierry Abribat, president and CEO of Alize Pharma. “In line with our business model, the results obtained from the first clinical trials will help us select a pharmaceutical partner capable of developing and commercializing the product under a licensing agreement.”

Alize’s UAG program was launched in 2007 and resulted in the discovery of AZP-531, the first unacylated ghrelin analog. This 8-amino acid peptide is stable and its pharmacokinetic properties make it suitable for pharmaceutical development. AZP-531 will be the first unacylated ghrelin analog to enter regulatory development.

“The mechanism of action of AZP-531 may lead to improved glycemia control in type 2 diabetes and also to positive effects on other cardiovascular risk factors, such as obesity, dyslipidemia and vascular complications,” explained Professor AJ van der Lely, head of the clinical endocrinology at the Erasmus Medical Center in Rotterdam, the Netherlands, and scientific advisor at Alize Pharma. “In addition, it could be used to target clinical conditions where acylated ghrelin levels are abnormally high, such as the Prader Willi syndrome, thus opening up a new treatment option for these patients.”

The company’s main shareholders participated in the funding round, namely Sham, Octalfa, CEMA and Thierry Abribat. Since its creation, Alize Pharma has raised a total of $10.3 million, has created value by reaching significant R&D milestones and has entered into its first strategic partnerships.

Share:          
CLINICAL TRIAL RESOURCES

Search:

NEWS ONLINE ARCHIVE

Browse by:

CWWeekly

October 20

Toronto Star, with FDA data, exposes weaknesses in Health Canada's clinical trial, inspection oversight

Crowdsourcing effort aims to fund updated online social media guide for sponsor interaction with patients

Already a subscriber?
Log in to your digital subscription.

Subscribe to CWWeekly.

The CenterWatch Monthly

September

Today's fastest, most economical sponsors
Standout sponsors reveal how they shorten regulatory, clinical cycle times

From the trenches: Sites' eye view of state of the industry
CW’s first site focus groups uncover frustration with 'progress,' but a passion for their mission

Already a subscriber?
Log in to your digital subscription.

Purchase the September issue.

Subscribe to
The CenterWatch Monthly.

The CenterWatch Monthly

August

Reality of costs and impact rain on Sunshine Act
Concerns mount over compliance burden on CROs, sponsors, unanticipated consequences for research

Cloud computing expanding into all areas of clinical trial conduct
Benefits outweigh the complexities, challenges of finding right vendors

Already a subscriber?
Log in to your digital subscription.

Purchase the August issue.

Subscribe to
The CenterWatch Monthly.

JobWatch centerwatch.com/jobwatch

Featured Jobs