« Return to News | Clinical Intelligence

Allon Therapeutics enrolls for frontal dementia trial

Thursday, May 19, 2011 10:49 AM

Allon Therapeutics is currently enrolling patients in a phase 2/3 study for its lead neuroprotective drug candidate, davunetide, a treatment for progressive supranuclear palsy (PSP), a form of frontotemporal dementia (FTD). Allon has completed two phase 2a human efficacy studies for davunetide in patients with amnesic mild cognitive impairment (aMCI), a precursor to Alzheimer’s disease, and in patients with cognitive impairment associated with schizophrenia (CIAS).

This phase 2/3 double-blinded, placebo-controlled trial will enroll approximately 300 patients randomized 1:1 to receive either placebo or 30 mg of davunetide intranasally twice daily for 12 months. This multi-national study is being conducted at premier medical institutions in the U.S., Australia, Germany, France, Canada and the U.K.

The primary outcome measures will be the progressive Supranuclear Palsy Rating Scale (PSPRS) and the Schwab and England Activities of Daily Living (SEADL) scale. Secondary measures will include Clinical Global Impression (CGI) and brain imaging by magnetic resonance tomography (MRI). Additional exploratory endpoints include cognitive and executive function as well as cerebrospinal fluid (CSF) biomarkers.

Share:          
CLINICAL TRIAL RESOURCES

Search:

NEWS ONLINE ARCHIVE

Browse by:

CWWeekly

December 17

Medici Global says its Alzheimer's Facebook page demonstrates the need for more early detection trials

Analysts: Expect more equity purchases of CROs in 2013

Already a subscriber?
Log in to your digital subscription.

Subscribe to CWWeekly.

The CenterWatch Monthly

January 2013

Parexel celebrates 30 years of change, growth
CRO's founder and chairman reflects on challenges of the past, present and future

Strategies for increasing patient diversity in trials
Sponsors look to improve racial, ethnic recruitment without going overseas

Already a subscriber?
Log in to your digital subscription.

Purchase the January issue.

Subscribe to The CenterWatch Monthly.

December 2012

Publicity, regulation tightening reins on use of KOLs
Debate rages over need to revamp how sponsors use, pay medical experts

Time may be right to makeover the investigator brochure
Size, complexity prevent critical document from being thoroughly read

Already a subscriber?
Log in to your digital subscription.

Purchase the December issue.

Subscribe to The CenterWatch Monthly.

JobWatch centerwatch.com/jobwatch

Featured Jobs

More Jobs

 

Copyright © 1995-2013 CenterWatch.