August 2014

WHO recommends use of testing to help diagnose pre-cancerous cervical disease

Friday, August 29, 2014

The World Health Organization (WHO) has issued new guidance recommending the use of p16 immunohistochemistry (IHC) testing to improve the detection of pre-cancerous cervical disease. In doing so, WHO is the first global organization to issue written recommendations on the use of p16 after the College of American Pathologists (CAP) and the American Society for Colposcopy and Cervical Pathology (ASCCP) provided similar guidance in 2012.

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Scientists looking across human, fly and worm genomes find shared biology

Thursday, August 28, 2014

Researchers analyzing human, fly, and worm genomes have found that these species have a number of key genomic processes in common, reflecting their shared ancestry.  The findings, appearing in the journal Nature, offer insights into embryonic development, gene regulation and other biological processes vital to understanding human biology and disease. 

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Amgen submits BLA for evolocumab to the FDA

Thursday, August 28, 2014

Amgen has submitted a Biologics License Application (BLA) to the FDA for evolocumab seeking approval for the treatment of high cholesterol. Evolocumab is an investigational, fully human monoclonal antibody that inhibits proprotein convertase subtilisin/kexin type 9 (PCSK9), a protein that reduces the liver’s ability to remove low-density lipoprotein cholesterol (LDL-C), or “bad” cholesterol, from the blood.

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