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AstraZeneca in-licenses Synairgen’s SNG001 for asthma in $232M deal

Thursday, June 12, 2014

AstraZeneca has inked a global license agreement with Synairgen, a U.K. company specializing in respiratory diseases, for SNG001, a novel, inhaled interferon beta (IFN-beta) in clinical development for treating respiratory tract viral infections in patients with severe asthma. SNG001 supports the immune system by correcting a deficiency which makes patients vulnerable to respiratory tract viral infections.

AstraZeneca will pay Synairgen a $7.25 million up-front fee and potential development, regulatory and commercial milestones of up to $225 million. In addition, AstraZeneca will pay tiered royalties ranging from single-digit up to mid-teens on commercial sales. AstraZeneca will be responsible for future development costs.

In early 2015, AstraZeneca will commence a phase IIa study in patients with severe asthma, building on available clinical data from an initial phase lla trial in a broad asthma population. SNG001 also provides the opportunity to expand the clinical program in other pulmonary diseases including chronic obstructive pulmonary disease (COPD).

Maarten Kraan, head of respiratory, inflammation and autoimmune innovative medicines, AstraZeneca, said, “Respiratory disease is a core therapeutic area for AstraZeneca, and a key growth platform for the company. Our approach includes addressing associated complications that patients experience, as well as developing treatments for the underlying disease. SNG001 is an innovative and targeted therapy that has, if successful, the potential to offer a step-change in the treatment of severe asthma, and possibly COPD.”

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