Lamisil Solution, 1%
The following drug information is obtained from various newswires, published
medical journal articles, and medical conference presentations.
General Information
Lamisil Solution, 1% is a synthetic antifungal compound approved
for the topical treatment of tinea (pityriasis) versicolor due to
Malassezia furfur, and tinea pedis (athlete's foot), tinea
cruris (jock itch), or tinea corporis (ringworm), due to
Trichophyton rubrum, Trichophyton mentagrophytes, or Epidermaphyton
floccosum.
Lamisil Solution, 1% is designed for one week usage and is
administered to the infected area once or twice daily, depending on
indication.
Clinical Results
The effectiveness of Lamisil Solution, 1% was evaluated in
separate eight week placebo-controlled trials for tinea
(pityriasis) versicolor, tinea pedis, and tinea corporis/cruris,
involving a total of 898 subjects. In the majority of pateints,
relief of symptoms began within the one week treatment period and
continued improvement was recorded over the following seven weeks.
(from Lamisil Solution, 1% Prescribing Information)
Side Effects
Adverse events associated with the use of terbinafine
hydrochloride may include (but are not limited to) the
following:
- site irritation
- itching
- skin exfoliation
- erythematous rash
Mechanism of Action
Lamisil Solution, 1% (terbinafine hydrochloride solution) is a
synthetic allyamine derivative. Terbinafine hydrochloride is
thought to act by inhibiting the epoxidation of squalene, thus
blocking the biosysnthesis of ergosterol, an essential component of
fungal cell membranes. Depending on the concentration of the drug
and the fungal species being tested in vitro, terbinafine
hydrochloride may be fungicidal. (from Lamisil Solution, 1%
Prescribing Information)
Additional Information
For additional information on Lamisil Solution, 1%, please visit
Novartis.
