Tri-Nasal Spray (triamcinolone acetonide spray)
The following drug information is obtained from various newswires, published
medical journal articles, and medical conference presentations.
Tri-Nasal Spray, administered intranasally, has been approved
for the treatment of nasal symptoms of seasonal and perennial
allergic rhinitis in adults & children 12 years of age or
older. These symptoms include sneezing, stuffiness, discharge, and
itching. Starting dose is 200 mcg for most patients, although
dosing should be individualized based on such variables as degree
of patient allergy and degree of pollen exposure.
Allergic rhinitis, otherwise known as hay fever, occurs when the
immune system reacts to pollens and other allergens. Allergies can
be hereditary or they can be triggered by environmental or even
Eight controlled clinical trials investigated 746 patients with
either perennial or seasonal allergic rhinitis. Results indicated
that 200 mcg daily of the study drug significantly relieved nasal
symptoms of the seasonal rhinitis. In one trial, only the
400 mcg dose (and not the 200 mcg dose) showed significant
improvement of nasal symptoms over placebo.
In rare cases, the development of localized infections of the
nose and pharynx has occurred.
It has been shown in clinical studies that intranasal
corticosteroids may cause a reduction in growth velocity in
pediatric patients. Pediatric patients should therefore be
monitored closely when taking this medication. Furthermore,
children should be given the lowest effective dosage.
Other adverse events include:
- Back pain
- Taste perversion
Mechanism of Action
Triamcinolone acetonide is a more potent derivative of
triamcinolone. Triamcinolone acetonide is approximately eight times
more potent than prednisone in animal models of inflammation.
Although the precise mechanism of corticosteroid antiallergic
action is unknown, corticosteroids are very effective. When
allergic symptoms are very severe, local treatment with recommended
doses (microgram) of available topical corticosteroids are not as
effective as treatment with larger doses (milligram) of oral or
parenteral formulations. (From FDA Label)
Visit the web site of the Asthma and Allergy Foundation of
America, a not-for-profit organization dedicated to finding a cure
for and controlling asthma and allergic diseases: