Periostat (doxycycline hyclate)
The following drug information is obtained from various newswires, published
medical journal articles, and medical conference presentations.
General Information
Periostat is indicated for use as an adjunct to scaling and root
planing to promote attachment level gain and to reduce pocket depth
in patients with adult periodontitis.
Side Effects
This drug is contraindicated in persons who have shown
hypersensitivity to any of the tetracyclines.
Mechanism of Action
Doxycycline has been shown to inhibit collagenase activity in
vitro. Additional studies have shown that doxycycline reduces the
elevated collagenase activity in the gingival crevicular fluid of
patients with adultperiodontitis. The clinical significance of
these findings is not known.
Literature References
1.
Golub L.M., Sorsa T., Lee H-M., Ciancio S., Sorbi D., Ramamurthy
N.S., Gruber B., Salo T., Konttinen Y.T.: Doxycycline Inhibits
Neutrophil (PMN)-type Matrix Metalloproteinases in Human Adult
Periodontitis Gingiva. J. Clin. Periodontol 1995; 22: 100-109.
2.
Golub L.M., Ciancio S., Ramamurthy N.S., Leung M., McNamara T.F.:
Low-dose Doxycycline Therapy: Effect on Gingival and Crevicular
Fluid Collagenase Activity in Humans. J. Periodont Res 1990; 25:
321-330
3.
Golub L.M., Lee H.M., Greenwald R.A., Ryan M.E., Salo T.,
Giannobile W.V.: A Matrix Metalloproteinase Inhibitor Reduces
Bone-type Collagen Degradation Fragments and Specific Collegenases
in Gingival Crevicular Fluid During Adult Periodontitis.
Inflammation Research 1997; 46: 310-319.
4.
Saivain S., Houin G.: Clinical Pharmacokinetics of Doxycycline and
Minocycline. Clin. Pharmacokinetics 1988; 15; 355-366.
5.
Schach von Wittenau M., Twomey T.: The Disposition of Doxycycline
by Man and Dog. Chemotherapy 1971; 16: 217-228.
6.
Campistron G., Coulais Y., Caillard C., Mosser J., Pontagnier H.,
Houin G.: Pharmacokinetics and Bioavailability of Doxycycline in
Humans. Arzneimittel Forschung 1986; 36: 1705-1707.
