Home » Drug Information » FDA Approved Drugs » 1997
Medical Areas: Pediatrics/Neonatology | Pharmacology/Toxicology
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The following drug information is obtained from various newswires, published
medical journal articles, and medical conference presentations.
Company: Orphan Medical
Approval Status: Approved December 1997
Treatment Area: ethylene glycol poisoning
Antizol (fomepizole) Injection is the first drug indicated as an
antidote for ethylene glycol poisoning or for use in suspected
ethylene glycol ingestion.
Therapy with Antizol has shown minimal central nervous system
depressant effects. The most frequent adverse reactions to Antizol
are headache (12%), nausea (11%), and dizziness (7%). Minor
allergic reactions have been reported.
Mechanism of Action
Antizol, commonly known as 4-MP (4-methylpyrazole), is a
synthetic alcohol dehydrogenase inhibitor. Antizol effectively
blocks formation of toxic ethylene glycol metabolites, which are
responsible for metabolic acidosis and renal damage.
Ethylene glycol is the main component of antifreeze and
coolants. Acute ethylene glycol poisoning is considered a medical
emergency that is characterized by a syndrome that can include
central nervous system depression, severe metabolic acidosis, renal
failure, and coma. It can be lethal if left untreated or when
treatment is delayed due to delayed diagnosis.